Emerging Applications of Nanotechnology for Controlling Cell‐Surface Receptor Clustering

Abstract

The spatial organization of cell‐surface receptors plays an important role in defining cell fate. Recently, the development of strategies for the direct regulation of receptor clustering using nanomaterials has aroused enormous interest. In this review, we discuss the mechanisms and features of recently developed nanomaterial‐based strategies to control the nanoscale distribution of cell binding ligands and regulate cell behavior. We expect this review to inspire innovative work on manipulating cell functions by controlling the clustering of cell surface receptors.

Neue Mitglieder der Chinesischen Akademie der Wissenschaften

“…Li interessiert sich für elektroanalytische Chemie und Bioanalyse, Nanoanalyse und Biosensoren sowie für Elektrochemie im Zusammenhang mit Physik, Nanowissenschaften, Materialien und Grenzflächen. In der Angewandten Chemie hatte er eine Zuschrift mit Rücktitelbild über markierungsfreie Bildgebung zellulärer Calcium‐Signalprozesse und einen Kurzaufsatz über die nanotechnologisch kontrollierte Zusammenlagerung von Zelloberflächenrezeptoren . Li ist im Redaktionsbeirat von Small Methods .…”

Biomaterials as Tools to Decode Immunity

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“…This precise control allows for the elucidation of relationships between properties such as antigen density and a particular immunological outcome. For example, the type of antibodies a B cell secretes to neutralize extracellular pathogens depends on the number and affinity of interactions the B cell has with antigen and helper immune cells during activation . At a larger length scale, biomaterials allow defined perturbations of cellular interactions or signaling.…”

Engineering Cell‐Surface Receptors with DNA Nanotechnology for Cell Manipulation

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“…[2] The receptor-mediated processes that convert multiple extracellular inputs into cell behavior are highly complex and sensitive to spatiotemporal changes in the variable environmentalinputs. [3] The cell-surface receptor is an integral player in cell signaling, so understanding how ar eceptor is regulated to elicit different cellular responses is critical to developing rational cellbased strategiesf or treating diseases and engineering regenerative tissue. However,t he detailed mechanisms of how regulatory modes of receptors lead to different cell behaviora re still poorly understood.U nder physiological conditions, homeostatic controlo ver receptor-mediated signaling plays an essential role in embryogenesis, stem cell differentiation, wound repair, and immune activation.…”