Emerging Applications of Some Important Natural Compounds in the Field of Oncology

Abstract

Cancer is among the leading causes of death worldwide, with several malignancies presenting an increase in their incidence, such as thyroid cancer, hepatocellular carcinoma, skin melanoma, uterine cancer, and oral cavity cancer. Phytochemicals have long been used in various fields of medicine for their properties, and the discovery of anti-tumour, anti-oxidant, and anti-inflammatory effects of some of these substances have prompted their application in the field of oncology. Several in vivo and in vitro studies have demonstrated the effectiveness of some phytochemicals on specific tumour cell lines, revealing their potential role in the complementary treatment of cancer. This paper addresses the anti-tumour and chemopreventive roles of various phytochemicals in malignancies with increasing incidence. Rezumat Cancerul este una dintre cele mai frecvente cauze de mortalitate din lume, câteva dintre aceste patologii prezentând creșteri ale incidenței, cum ar fi cancerul tiroidian, carcinomul hepatocelular, melanomul cutanat, cancerul uterin și carcinomul cavității orale. Substanțele fitochimice au fost utilizate mult timp în diverse domenii ale medicinei pentru proprietățile lor, iar descoperirea efectelor anti-tumorale, anti-oxidante și anti-inflamatorii ale unora dintre aceste substanțe au încurajat utilizarea acestora în domeniul oncologiei. Unele studii in vivo și in vitro au demonstrat eficiența unor fitochimicale pe anumite linii celulare tumorale, evidențiind rolul lor potențial în tratamentul complementar al cancerului. Această lucrare se referă la rolurile anti-tumorale și chemopreventive ale diverselor fitochimicale în malignitățile cu incidență în creștere.

Cannabinoids and Inflammations of the Gut-Lung-Skin Barrier

“…However, due to adverse effects and interactions, there is a growing interest in medicinal-grade natural compounds that have demonstrated their effectiveness and usually act through dedicated receptors that are widely distributed in the human body. These substances have been labeled 'phytochemicals', and some examples include capsaicin, curcumin, resveratrol and cannabinoids [21][22][23][24]. Curcumin, resveratrol, gingerol, and ginsenoside have demonstrated antioxidant and antiinflammatory effects by modulating the MAP and NF-κB pathways, making them excellent candidates in the treatment of atopic dermatitis [25].…”

The Role of Serum Ions Deficiencies in the Pathogenic Mechanisms of Oncological Depression – Psycho-Pharmacological Particularities

“…In cancer, the emergence of somatic and psychiatric comorbidities, especially chronic pain, requires the association of drugs that can increase serum sodium deficiency (antidiuretics, antidepressants, antiepileptics used to treat seizures caused by brain metastases or for analgesic effectsgabapentin, pregabalin), independent of oncological medication [21,36,61].…”

Platinum Hypersensitivity Reactions, a Focus on Desensitisation

“…Many of the oncological patients uses "supplements", which are considered harmless due to their natural origin. In fact, some of them could enhance the effect of chemotherapy (for cisplatin for example), but in the most of the cases it could increase the risk of an allergic reaction [69].…”