Emerging biomarkers in Multiple Myeloma: A review

Gupta, Nidhi; Sharma, Aparna; Sharma, Alpana

doi:10.1016/j.cca.2019.12.026

Cited by 50 publications

(38 citation statements)

References 78 publications

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“…Albumin and globulin have attracted wide attention as noninvasive prognostic factors of tumors. Albumin can be used to reflect the nutritional and systemic inflammatory status of cancer patients and can be used as a prognostic marker for diverse cancers, such as lung cancer (4), lymphoma (5), renal cell carcinoma (6), breast cancer (7,8) and gastrointestinal cancers (9). Globulin, as one of the main cortisol-binding proteins, can participate in immune and inflammatory responses (10).…”

Section: Introductionmentioning

confidence: 99%

A Low Albumin-to-Globulin Ratio Predicts a Poor Prognosis in Patients With Metastatic Non-small-cell Lung Cancer

Lü

Wei

et al. 2021

Front. Med.

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Objective: The serum albumin-to-globulin ratio (AGR) may be a useful prognostic factor for various cancers. This study aimed to evaluate the prognostic value of the AGR in patients with metastatic non-small-cell lung cancer (NSCLC).Methods: A retrospective study was conducted on patients with stage IV NSCLC diagnosed in Hubei Cancer Hospital from July 2012 to December 2013. The formula for calculating the AGR was serum albumin/total protein-serum albumin. The chi-square test or Fisher's exact test was used to analyze the classified variables. The Kaplan-Meier method was used to analyze the overall survival (OS) rate, which was plotted with the R language. The impact of the AGR on OS and progression-free survival (PFS) was analyzed by a multivariate Cox proportional hazard model.Results: A total of 308 patients were included in the study population. The optimal cutoff values for the AGR in terms of OS and PFS were 1.12 and 1.09, respectively, as determined by X-Tile software. Kaplan-Meier curve analysis showed that the difference in survival rate between patients with different AGR levels was statistically significant (p = 0.04). The OS of patients with a high AGR (≥1.12) was longer than that of patients with a low AGR (<1.12). PFS in the high AGR group were better than those in the low AGR group (16.90 vs. 32.07months, p = 0.008). The univariate and multivariate models proved that the AGR was an independent prognostic factor in metastatic NSCLC patients in terms of both OS (p = 0.009, hazard ratio [HR] = 0.55, 95% confidence interval [95% CI] = 0.35–0.86) and PFS (p = 0.004, HR = 0.55, 95% CI = 0.37–0.83).Conclusion: The AGR, which is measured in routine clinical practice, is an independent prognostic factor in terms of OS and PFS in metastatic NSCLC and can serve as a prognostic tool for metastatic NSCLC.

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Section: Introductionmentioning

confidence: 99%

A Low Albumin-to-Globulin Ratio Predicts a Poor Prognosis in Patients With Metastatic Non-small-cell Lung Cancer

Lü

Wei

et al. 2021

Front. Med.

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“…b2-MG, IL-6, LDH, Hb, Alb, and Scr are important diagnostic markers assessed in the clinic. [22][23][24] We evaluated the correlations of SF levels with these factors in patients with newly diagnosed MM. Notably, SF levels exhibited positive correlations with b2-MG (r ¼ 0.510, P ¼ 0.011, Figure 2c), IL-6 (r ¼ 0.651, P ¼ 0.010, Figure 2d), and LDH expression (r ¼ 0.524, P ¼ 0.009, Figure 2e).…”

Section: Increased Sf Content Was Detected In Patients During MM Progmentioning

confidence: 99%

The iron chelator deferoxamine decreases myeloma cell survival

Yang

Dai

et al. 2021

J Int Med Res

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Objective This study evaluated serum ferritin (SF) levels and investigated their relationships with various clinical markers in patients with multiple myeloma (MM). Furthermore, the effects and molecular mechanism of deferoxamine (DFO) in myeloma cells were studied. Methods Clinical data from 84 patients with MM were collected to evaluate SF content and its relationship with several important clinical parameters. MM1S and MM1R myeloma cells were chosen to investigate the effects of iron and DFO on cell survival and apoptosis. Results Increased SF levels were detected in newly diagnosed patients, especially those with stage III disease or the κ isotype. SF content was positively correlated with β2-microglobulin, interleukin-6, and lactate dehydrogenase expression. Furthermore, patients with progressive or relapsed disease had higher SF levels. Importantly, iron chelation with DFO efficiently inhibited myeloma cell survival and accelerated apoptosis by regulating apoptosis-related genes. Conclusions The importance of SF for MM was highlighted. Additionally, it is suggested that DFO may be a good therapeutic option for MM.

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“…It is well known that the initiation and progression of multiple myeloma are related to genetic and epigenetic regulation as well as the activation of oncogenic genes and/or inactivation of tumor suppressor genes. Although various biomarkers have been considered to be related to multiple myeloma diagnoses in clinical practice, including β2-MG, light chain λ/κ, and β-CTX, their reliability remains controversial [6,7]. Therefore, it is critical to identify novel mechanisms involved in the aggressive progression of multiple myeloma and to enhance the diagnosis and treatment strategies for multiple myeloma patients.…”

Section: Introductionmentioning

confidence: 99%

CircRNA circ_0001821 predicts an unfavorable prognosis and promotes the proliferation of multiple myeloma

Liu

Zhang

2021

Hematology

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Background: A previous study reported circ_0001821 serves as a new diagnostic biomarker in lung and gastric cancer. However, whether circ_0001821 associates with the development of multiple myeloma is still unclear. Objective: To investigate the clinical significance and biological function of circ_0001821 in human multiple myeloma. Methods: The expression of circ_0001821 in bone marrow tissues and cell lines of multiple myeloma was detected by quantitative real-time PCR. The relationship between circ_0001821 expression and clinicopathological characteristics in multiple myeloma patients was determined by the Chi-square test. MTT, Western blotting analysis and flow cytometry were performed to evaluate the impact of circ_0001821 on cell proliferation and apoptosis. Results: Circ_0001821 expression was increased in bone marrow tissues and cell lines from multiple myeloma compared with that in normal controls, and its expression was related to hemoglobin, bone injury, β2-MG, and globulin. In multiple myeloma patients aged ≥60 years, high circ_0001821 expression displayed lower overall survival (OS) rate compared with low circ_0001821 expression. High circ_0001821 expression was an independent prognostic indicator for the poor OS. Furthermore, the expression of Caspase-3 protein was lower in patients with high circ_0001821 expression than that in those patients with low circ_0001821expression. Overexpression of circ_0001821 led to increased proliferation and arrested apoptosis of multiple myeloma cells, while knockdown of circ_0001821 had the opposite effects. Conclusion: High expression of circ_0001821 associated with aggressive pathological indicators and predicted a poor prognosis in multiple myeloma. Circ_0001821 played an oncogenic role in multiple myeloma by modulating cell proliferation and apoptosis.

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Emerging biomarkers in Multiple Myeloma: A review

Cited by 50 publications

References 78 publications

A Low Albumin-to-Globulin Ratio Predicts a Poor Prognosis in Patients With Metastatic Non-small-cell Lung Cancer

A Low Albumin-to-Globulin Ratio Predicts a Poor Prognosis in Patients With Metastatic Non-small-cell Lung Cancer

The iron chelator deferoxamine decreases myeloma cell survival

CircRNA circ_0001821 predicts an unfavorable prognosis and promotes the proliferation of multiple myeloma

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