Emerging biomedical applications of polyaspartic acid-derived biodegradable polyelectrolytes and polyelectrolyte complexes

Yavvari, Prabhu Srinivas; Awasthi, Anand Kumar; Sharma, Aashish; Bajaj, Avinash; Srivastava, Aasheesh

doi:10.1039/c8tb02962h

Cited by 41 publications

(46 citation statements)

References 130 publications

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“…The reactions catalyzed by phosphoric acid yield linear chain whereas uncatalyzed reactions lead to branching (Wolk et al, 1994). High temperature, high catalyst, and aspartic acid monomer concentration can significantly increase molecular weight (Mw) (Jalalvandi and Shavandi, 2018; Yavvari et al, 2019). Recent studies have also shown when phosphoric acid is utilized as both catalyst and polymerization media (aspartic acid monomer: phosphoric acid, 1:1), PASP with high Mw and reaction yield is achieved (Zakharchenko et al, 2011; Moon et al, 2013; Szilágyi et al, 2017).…”

Section: Synthesis Of Polyaspartic Acidmentioning

confidence: 99%

Hydrogels Based on Poly(aspartic acid): Synthesis and Applications

et al. 2019

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This review presents an overview on the recent progress in the synthesis, crosslinking, interpenetrating networks, and applications of poly(aspartic acid) (PASP)-based hydrogels. PASP is a synthetic acidic polypeptide that has drawn a great deal of attention in diverse applications due particularly to its biocompatibility and biodegradability. Facile modification of its precursor, poly(succinimide) (PSI), by primary amines has opened a wide window for the design of state-of-the-art hydrogels. Apart from pH-sensitivity, PASP hydrogels can be modified with suitable species in order to respond to the other desired stimuli such as temperature and reducing/oxidizing media as well. Strategies for fabrication of nanostructured PASP-based hydrogels in the form of particle and fiber are also discussed. Different cross-linking agents for PSI/PASP such as diamines, dopamine, cysteamine, and aminosilanes are also introduced. Finally, applications of PASP-based hydrogels in diverse areas particularly in biomedical are reviewed.

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Section: Synthesis Of Polyaspartic Acidmentioning

confidence: 99%

Hydrogels Based on Poly(aspartic acid): Synthesis and Applications

et al. 2019

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“…Although the preparation of most types of poly(amino acid)s is expensive, the synthesis of PASP can be relatively cost-efficient, and it does not require extreme conditions, as we described previously [25,[37][38][39][40]. In the last decades, the interest of scientists in PASP-based hydrogels increased significantly due to their potential applications in medical, pharmaceutical and environmental fields [25,34,[41][42][43][44]. Several publications can be found concerning different types of cross-linkers to prepare PASP-based hydrogels [22,34,45].…”

Section: Introductionmentioning

confidence: 99%

Fully amino acid-based hydrogel as potential scaffold for cell culturing and drug delivery

Juriga¹,

Sipos²,

Hegedűs³

et al. 2019

Beilstein J. Nanotechnol.

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Polymer hydrogels are ideal scaffolds for both tissue engineering and drug delivery. A great advantage of poly(amino acid)-based hydrogels is their high similarity to natural proteins. However, their expensive and complicated synthesis often limits their application. The use of poly(aspartic acid) (PASP) seems an appropriate solution for this problem due to the relatively cheap and simple synthesis of PASP. Using amino acids not only as building blocks in the polymer backbone but also as cross-linkers can improve the biocompatibility and the biodegradability of the hydrogel. In this paper, PASP cross-linked with cystamine (CYS) and lysine-methylester (LYS) was introduced as fully amino acid-based polymer hydrogel. Gels were synthesized employing six different ratios of CYS and LYS. The pH dependent swelling degree and the concentration of the elastically active chain were determined. After reduction of the disulfide bonds of CYS, the presence of thiol side groups was also detected. To determine the concentration of the reactive cross-linkers in the hydrogels, a new method based on the examination of the swelling behavior was established. Using metoprolol as a model drug, cell proliferation and drug release kinetics were studied at different LYS contents and in the presence of thiol groups. The optimal ratio of cross-linkers for the proliferation of periodontal ligament cells was found to be 60−80% LYS and 20−40% CYS. The reductive conditions resulted in an increased drug release due to the cleavage of disulfide bridges in the hydrogels. Consequently, these hydrogels provide new possibilities in the fields of both tissue engineering and controlled drug delivery.

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“…The solid was dissolved in DMSO. The solution was dialyzed against water in a dialysis bag with a proper molecular cutoff and then solid m-PEG-b-PAsp was obtained by lyophilization (Yang et al, 2015;Yavvari et al, 2019).…”

Section: M-poly (Ethylene Glycol)-b-poly (Aspartate)mentioning

confidence: 99%

Phenylboronic ester-modified anionic micelles for ROS-stimuli response in HeLa cell

Wang

Zhang

et al. 2020

Drug Delivery

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Smart polymers as ideal drug nanocarriers have attracted much attention due to the effective drug delivery, internalization and release once triggered by intracellular stimuli, as well as reduced cytotoxicity. We here reported the anionic micelle consisting of copolymer (PEG-b-PAsp) and a PBE (Phenylboronic Ester) group grafted, which can achieve fast response to intracellular ROS and enhanced anti-tumor activity. With this, PEG-b-PAsp-g-PBE/DOX system showed better tumor growth inhibition when studied on HeLa cell lines with high level of intracellular ROS and its subcutaneous tumor models. Additionally, the administration of PEG-b-PAsp-g-PBE/DOX did cause significantly lower systemic toxicity in comparison with free DOX. Hence, PEG-b-PAsp-g-PBE could be a highly efficient and safe nanocarrier to improve the efficacy of chemotherapeutic.

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Emerging biomedical applications of polyaspartic acid-derived biodegradable polyelectrolytes and polyelectrolyte complexes

Cited by 41 publications

References 130 publications

Hydrogels Based on Poly(aspartic acid): Synthesis and Applications

Hydrogels Based on Poly(aspartic acid): Synthesis and Applications

Fully amino acid-based hydrogel as potential scaffold for cell culturing and drug delivery

Phenylboronic ester-modified anionic micelles for ROS-stimuli response in HeLa cell

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