Emerging biosensing technologies for improved diagnostics of COVID-19 and future pandemics

Chen, Linzhe; Zhang, Guoliang; Liu, Longqi; Li, Zida

doi:10.1016/j.talanta.2020.121986

Cited by 53 publications

(44 citation statements)

References 88 publications

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“…As public health concerns shift over time, the applications for biomarker detection follow suit. Beginning in early 2020, the SARS-CoV-2 pandemic led to the rapid development of diagnostic tests [ 47 ], resulting in new technologies that can now be adapted for other diseases. However, none of the works discussed in this review addresses SARS-CoV-2.…”

Section: Trends In Biomarker Detectionmentioning

confidence: 99%

Advances in multiplex electrical and optical detection of biomarkers using microfluidic devices

Mitchell

Esene

2021

Anal Bioanal Chem

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Graphical abstract Microfluidic devices can provide a versatile, cost-effective platform for disease diagnostics and risk assessment by quantifying biomarkers. In particular, simultaneous testing of several biomarkers can be powerful. Here, we critically review work from the previous 4 years up to February 2021 on developing microfluidic devices for multiplexed detection of biomarkers from samples. We focus on two principal approaches: electrical and optical detection methods that can distinguish and quantify biomarkers. Both electrical and spectroscopic multiplexed detection strategies are being employed to reach limits of detection below clinical sample levels. Some of the most promising strategies for point-of-care assays involve inexpensive materials such as paper-based microfluidic devices, or portable and accessible detectors such as smartphones. This review does not comprehensively cover all multiplexed microfluidic biomarker studies, but rather provides a critical evaluation of key work and suggests promising prospects for future advancement in this field. Electrical and optical multiplexing are powerful approaches for microfluidic biomarker analysis.

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Section: Trends In Biomarker Detectionmentioning

confidence: 99%

Advances in multiplex electrical and optical detection of biomarkers using microfluidic devices

Mitchell

Esene

2021

Anal Bioanal Chem

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“…This comprehensive review article focuses on the most recent advances in POC diagnostic devices for potential diagnosis of COVID-19 that meet ASSURED criteria, which is distinct from previous review papers where nanomaterial-based biosensors [30][31][32][33] and non-POC diagnostic techniques [34][35][36][37][38][39][40][41][42][43][44] were summarized. In addition, the commercial POC biosensors have not been critically reviewed [45][46][47][48].…”

Section: Introductionmentioning

confidence: 99%

Emerging point-of-care biosensors for rapid diagnosis of COVID-19: current progress, challenges, and future prospects

Rasmi

Khan

et al. 2021

Anal Bioanal Chem

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Coronavirus disease 2019 (COVID-19) pandemic is currently a serious global health threat. While conventional laboratory tests such as quantitative real-time polymerase chain reaction (qPCR), serology tests, and chest computerized tomography (CT) scan allow diagnosis of COVID-19, these tests are time-consuming and laborious, and are limited in resource-limited settings or developing countries. Point-of-care (POC) biosensors such as chip-based and paper-based biosensors are typically rapid, portable, cost-effective, and user-friendly, which can be used for COVID-19 in remote settings. The escalating demand for rapid diagnosis of COVID-19 presents a strong need for a timely and comprehensive review on the POC biosensors for COVID-19 that meet ASSURED criteria: Affordable, Sensitive, Specific, User-friendly, Rapid and Robust, Equipment-free, and Deliverable to end users. In the present review, we discuss the importance of rapid and early diagnosis of COVID-19 and pathogenesis of COVID-19 along with the key diagnostic biomarkers. We critically review the most recent advances in POC biosensors which show great promise for the detection of COVID-19 based on three main categories: chip-based biosensors, paper-based biosensors, and other biosensors. We subsequently discuss the key benefits of these biosensors and their use for the detection of antigen, antibody, and viral nucleic acids. The commercial POC biosensors for COVID-19 are critically compared. Finally, we discuss the key challenges and future perspectives of developing emerging POC biosensors for COVID-19. This review would be very useful for guiding strategies for developing and commercializing rapid POC tests to manage the spread of infections.

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“…Throughout the epidemic in Qatar, we implemented a sequencing strategy to detect, monitor, and evaluate the spread of the virus, including the VOC. Such sequencing efforts were crucial towards understanding the epidemiological and clinical significance of variants, especially when it comes to estimating reinfection rates and vaccine effectiveness [12][13][14][15][16]. Here we report on the clusters of SARS-CoV-2 infection reported in Qatar for the past year, intending to understand the origin, evolution, transmission patterns of the virus.…”

Section: Introductionmentioning

confidence: 99%

One year of SARS-CoV-2: Genomic characterization of COVID-19 outbreak in Qatar

Benslimane

Al-Khatib

Al-Jamal

et al. 2021

Preprint

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The state of Qatar has emerged as a major transit hub connecting all parts of the globe, making it as a hotspot for infectious disease introduction and providing an ideal setting to monitor the emergence and spread of variants. In this study, we report on 2634 SARS-CoV-2 whole-genome sequences from infected patients in Qatar between March-2020 and March-2021, representing 1.5% of all positive cases in this period. Despite the restrictions on international travel, the viruses sampled from the populace of Qatar mirrored nearly the entire global population's genomic diversity with nine predominant viral lineages that were sustained by local transmission chains and the emergence of mutations that are likely to have originated in Qatar. We reported an increased number in the mutations and deletions in B.1.1.7 and B.1.351 lineages in a short period. This raises the imperative need to continue the ongoing genomic surveillance that has been an integral part of the national response to monitor SARS-CoV-2 profile and re-emergence in Qatar.

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Emerging biosensing technologies for improved diagnostics of COVID-19 and future pandemics

Cited by 53 publications

References 88 publications

Advances in multiplex electrical and optical detection of biomarkers using microfluidic devices

Advances in multiplex electrical and optical detection of biomarkers using microfluidic devices

Emerging point-of-care biosensors for rapid diagnosis of COVID-19: current progress, challenges, and future prospects

One year of SARS-CoV-2: Genomic characterization of COVID-19 outbreak in Qatar

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