Emerging clinical significance of claudin-7 in colorectal cancer: a review

Wang, Kun; Xu, Chang; Li, Wenjing; Ding, Lei

doi:10.2147/cmar.s175383

Cited by 28 publications

(42 citation statements)

References 107 publications

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“…Interestingly, overexpression of claudin 7 leads to increased invasiveness in the gastric cell line AGS ( Zavala-Zendejas et al, 2011 ). However, claudin 7 expression is either up- or downregulated in several cancer types, and dysregulated protein levels might interfere with its epithelial barrier function, leading to impaired tissue homeostasis ( Wang et al, 2018 ). Moreover, cytoplasmic staining for claudin 7 has been reported in GC tissues ( Johnson et al, 2005 ).…”

Section: Resultsmentioning

confidence: 99%

A Non-canonical Wnt Signature Correlates With Lower Survival in Gastric Cancer

Astudillo

2021

Front. Cell Dev. Biol.

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Genetic evidence suggests a role for the Wnt/β-catenin pathway in gastric cancer. However, Wnt5a, regarded as a prototypical non-canonical Wnt ligand, has also been extensively associated with this disease. Therefore, the roles of the Wnt signaling pathway in gastric cancer initiation and progression, and particularly the precise mechanisms by which the non-canonical Wnt pathway might promote the development and progression of gastric cancer, are not entirely well understood. This article analyzes publicly available gene and protein expression data and reveals the existence of a WNT5A/FZD2/FZD7/ROR2 signature, which correlates with tumor-infiltrating and mesenchymal cell marker expression. High expression of FZD7 and ROR2 correlates with a shared gene and protein expression profile, which in turn correlates with poor prognosis. In summary, the findings presented in this article provide an updated view of the relative contributions of the Wnt/β-catenin and non-canonical Wnt pathways in gastric cancer.

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Section: Resultsmentioning

confidence: 99%

A Non-canonical Wnt Signature Correlates With Lower Survival in Gastric Cancer

Astudillo

2021

Front. Cell Dev. Biol.

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“…The interactions between claudin family members are both homophilic and heterophilic and are considered to play a significant role in the progression of CRC and several other cancers [99]. The progression of colon cancer has been linked with the dysregulation of the CLDN-1 expression causing disorganization of the tight junction fibrils leading to increased paracellular permeability [100]. Increased potential for invasion and metastasis has been demonstrated in xenografts that express CLDN-1 [101].…”

Section: Claudin-1 and Colorectal Cancermentioning

confidence: 99%

Claudin-1, A Double-Edged Sword in Cancer

Bhat

Syed

Therachiyil

et al. 2020

IJMS

102

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Claudins, a group of membrane proteins involved in the formation of tight junctions, are mainly found in endothelial or epithelial cells. These proteins have attracted much attention in recent years and have been implicated and studied in a multitude of diseases. Claudins not only regulate paracellular transepithelial/transendothelial transport but are also critical for cell growth and differentiation. Not only tissue-specific but the differential expression in malignant tumors is also the focus of claudin-related research. In addition to up- or down-regulation, claudin proteins also undergo delocalization, which plays a vital role in tumor invasion and aggressiveness. Claudin (CLDN)-1 is the most-studied claudin in cancers and to date, its role as either a tumor promoter or suppressor (or both) is not established. In some cancers, lower expression of CLDN-1 is shown to be associated with cancer progression and invasion, while in others, loss of CLDN-1 improves the patient survival. Another topic of discussion regarding the significance of CLDN-1 is its localization (nuclear or cytoplasmic vs perijunctional) in diseased states. This article reviews the evidence regarding CLDN-1 in cancers either as a tumor promoter or suppressor from the literature and we also review the literature regarding the pattern of CLDN-1 distribution in different cancers, focusing on whether this localization is associated with tumor aggressiveness. Furthermore, we utilized expression data from The Cancer Genome Atlas (TCGA) to investigate the association between CLDN-1 expression and overall survival (OS) in different cancer types. We also used TCGA data to compare CLDN-1 expression in normal and tumor tissues. Additionally, a pathway interaction analysis was performed to investigate the interaction of CLDN-1 with other proteins and as a future therapeutic target.

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“…This state is linked to the downregulation of the transcription factor Ovol1 (Jia et al, 2015; Saxena, Srikrishnan, Celia-Terrassa, & Jolly, 2020), which suppresses a mesenchymal identity, and the tight junction component, Claudin7 (Aiello et al, 2018; W. K. Kim et al, 2019; Wang, Xu, Li, & Ding, 2018). Notably, both of these factors were also significantly downregulated in Rreb1 −/− embryos (Figure S6A).…”

Section: Resultsmentioning

confidence: 99%

The transcription factor Rreb1 regulates epithelial architecture and invasiveness in gastrulating mouse embryos

Morgani

Nichols

et al. 2020

Preprint

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Ras-responsive element-binding protein 1 (Rreb1) is a zinc-finger transcription factor downstream of RAS signaling. Rreb1 has been implicated in cancer but little is known about its role in mammalian non-disease states. Here, we found that Rreb1 is essential for mouse embryonic development. Loss of Rreb1 led to a reduction in the expression of vasculogenesis factors, cardiovascular defects and embryonic lethality. During gastrulation, the absence of Rreb1 also resulted in the upregulation of cytoskeleton-associated genes, a change in the organization of F-ACTIN and adherens junctions within the pluripotent epiblast, and perturbed epithelial architecture characterized by irregular tissue folding and abnormal accumulations of cells. Moreover, Rreb1 mutant cells ectopically exited the epiblast epithelium through the underlying basement membrane, paralleling cell behaviors observed during metastasis. Thus, disentangling the function of Rreb1 in development could shed light on its role in cancer and other diseases involving loss of epithelial integrity.

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Emerging clinical significance of claudin-7 in colorectal cancer: a review

Cited by 28 publications

References 107 publications

A Non-canonical Wnt Signature Correlates With Lower Survival in Gastric Cancer

A Non-canonical Wnt Signature Correlates With Lower Survival in Gastric Cancer

Claudin-1, A Double-Edged Sword in Cancer

The transcription factor Rreb1 regulates epithelial architecture and invasiveness in gastrulating mouse embryos

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