Emerging concepts of dietary therapy for pediatric and adult eosinophilic esophagitis

Davis, Benjamin P.; Rothenberg, Marc E.

doi:10.1586/eci.13.15

Cited by 15 publications

(11 citation statements)

References 20 publications

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“…16,17 Previous reviews detail the environmental etiology, the clinical presentation and manifestations, and critical molecular pathways of EoE. 13,14,18–25 This review will focus on the contribution of genetic variation on EoE risk. Specific EoE-risk loci will be reviewed in the context of what insight they provide into the molecular pathoetiology of EoE.…”

Section: Introductionmentioning

confidence: 99%

Genetics of eosinophilic esophagitis

Kottyan

Rothenberg

2017

Mucosal Immunology

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Eosinophilic esophagitis (EoE) is a chronic, allergic disease associated with marked mucosal eosinophil accumulation. EoE disease risk is multifactorial and includes environmental and genetic factors. This review will focus on the contribution of genetic variation to EoE risk, as well as the experimental tools and statistical methodology used to identify EoE risk loci. Specific disease-risk loci that are shared between EoE and other allergic diseases (TSLP, LRRC32) or unique to EoE (CAPN14), as well as Mendellian Disorders associated with EoE, will be reviewed in the context of the insight that they provide into the molecular pathoetiology of EoE. We will also discuss the clinical opportunities that genetic analyses provide in the form of decision support tools, molecular diagnostics, and novel therapeutic approaches.

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Section: Introductionmentioning

confidence: 99%

Genetics of eosinophilic esophagitis

Kottyan

Rothenberg

2017

Mucosal Immunology

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“…Oral steroids are effective for acute, severe, or difficult-to-control EoE (4). Allergen avoidance by dietary measures is successfully used for the treatment of EoE (11). Elemental formulas represent the most effective therapy in terms of both histologic and symptomatic response, with a response rate of 97%.…”

Section: Clinical Aspects Of Eoementioning

confidence: 99%

“…Antigen-directed diets appear to be as effective as the empiric elimination diet. There is controversy over whether an antigen-directed diet leads to a less restrictive diet; however, as the six-food elimination diet is difficult to achieve and maintain because it is highly restrictive, antigen testing may retain its value to specific patients as both a means to design patient-specific elimination diets and as a guide for the food reintroduction process (11). …”

Section: Clinical Aspects Of Eoementioning

confidence: 99%

Mechanisms of Disease of Eosinophilic Esophagitis

Davis

Rothenberg

2016

Annu. Rev. Pathol. Mech. Dis.

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Eosinophilic esophagitis (EoE) is a recently recognized inflammatory disease of the esophagus with clinical symptoms derived from esophageal dysfunction. The etiology of EoE is now being elucidated, and food hypersensitivity is emerging as the central cornerstone of disease pathogenesis. Herein, we present a thorough picture of the current clinical, pathologic, and molecular understanding of the disease with a focus on disease mechanisms.

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“…This allergic inflammatory condition of the esophagus is characterized also by swallowing difficulty, food impaction, refusal of food, difficulty in infant feeding, poor weight gain, and poor response to standard antireflux treatment; dietetic management is important [53]. Practically, all the clinical features of infants with allergic enteropathy are common to ‘chronic’ FPIES.…”

Section: Acute and Chronic Food Protein-induced Enterocolitis Syndromementioning

confidence: 99%

Differential diagnosis of food protein-induced enterocolitis syndrome

Fiocchi

Claps

Dahdah

et al. 2014

Current Opinion in Allergy &Amp; Clinical Immunology

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Purpose of reviewTo assess all the possible differential diagnosis of food protein-induced enterocolitis syndrome (FPIES), both in acute and chronic presentation, reviewing the data reported in published studies.Recent findingsThere is an increase of reported cases of FPIES in recent years. As the disease presents with nonspecific symptoms, it can be misunderstood in many ways. The differential diagnosis includes, in acute presentations, the following: sepsis, other infectious diseases, acute gastrointestinal episodes, surgical emergencies, food allergies. In its chronic forms, FPIES may mimic malabsorption syndromes, metabolic disorders, primary immunodeficiencies, neurological conditions, coagulation defects, and other types of non-IgE-mediated food allergy.SummaryA thorough clinical evaluation, including symptoms, signs, and laboratory findings, is necessary to lead the clinicians toward the diagnosis of FPIES. The major reason for delayed diagnosis appears to be the lack of knowledge of the disease.

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Emerging concepts of dietary therapy for pediatric and adult eosinophilic esophagitis

Cited by 15 publications

References 20 publications

Genetics of eosinophilic esophagitis

Genetics of eosinophilic esophagitis

Mechanisms of Disease of Eosinophilic Esophagitis

Differential diagnosis of food protein-induced enterocolitis syndrome

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