Emerging Effects of Resveratrol on Wound Healing: A Comprehensive Review

Jia, Yuan; Shao, Jia-Hao; Zhang, Kai-Wen; Zou, Ming-Li; Teng, Ying-Ying; Fan, Tingting; Chen, Meng-Nan; Chen, Weiwei; Yuan, Zheng‐Dong; Wu, Junjie; Yuan, Feng‐Lai

doi:10.3390/molecules27196736

Cited by 13 publications

(6 citation statements)

References 80 publications

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“…In mouse models of cutaneous cancers, resveratrol inhibited tumor growth, lowered tumor volume and weight, suppressed metastasis tendency, and increased survival time [257,258,261,265,270,271]. Also, resveratrol displayed beneficial effects in wound healing [272].…”

Section: Bitter Phytochemicals Active On Skin Inflammation Skin Carci...mentioning

confidence: 99%

Bitter Phytochemicals as Novel Candidates for Skin Disease Treatment

Grădinaru,

Vlad,

Gilca

2023

CIMB

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Skin diseases represent a global healthcare challenge due to their rising incidence and substantial socio-economic burden. While biological, immunological, and targeted therapies have brought a revolution in improving quality of life and survival rates for certain dermatological conditions, there remains a stringent demand for new remedies. Nature has long served as an inspiration for drug development. Recent studies have identified bitter taste receptors (TAS2Rs) in both skin cell lines and human skin. Additionally, bitter natural compounds have shown promising benefits in addressing skin aging, wound healing, inflammatory skin conditions, and even skin cancer. Thus, TAS2Rs may represent a promising target in all these processes. In this review, we summarize evidence supporting the presence of TAS2Rs in the skin and emphasize their potential as drug targets for addressing skin aging, wound healing, inflammatory skin conditions, and skin carcinogenesis. To our knowledge, this is a pioneering work in connecting information on TAS2Rs expression in skin and skin cells with the impact of bitter phytochemicals on various beneficial effects related to skin disorders.

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Section: Bitter Phytochemicals Active On Skin Inflammation Skin Carci...mentioning

confidence: 99%

Bitter Phytochemicals as Novel Candidates for Skin Disease Treatment

Grădinaru,

Vlad,

Gilca

2023

CIMB

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“…In several experimental murine models, RSV treatment increased cutaneous wound healing, inhibited excessive scarring, prevented skin photoaging, and stimulated chronic wound healing [215][216][217][218]. In STZ-induced C57/B6 diabetic mice, RSV 10 µmol/L, injected around the injury, induced M2 macrophage polarization, decreased the level of pro-inflammatory cytokines (TNF-α, IL-6, IL-1β), and accelerated the skin wound healing [219].…”

Section: Wound Healing Propertiesmentioning

confidence: 99%

Resveratrol: A Review on the Biological Activity and Applications

Bejenaru,

Biţă,

Belu

et al. 2024

Applied Sciences

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Resveratrol (RSV), a naturally occurring phytoalexin, is the most important stilbenoid synthesized by plants as a defense mechanism in response to microbial aggression, toxins, or ultraviolet radiation. RSV came to the attention of researchers both as a potential chemopreventive agent and a possible explanation for the low incidence of cardiovascular disease (CVD) in French people with a high-fat diet. RSV is mainly administered as a food supplement, and its properties are evaluated in vitro or in vivo on various experimental models. RSV modulates signaling pathways that limit the spread of tumor cells, protects nerve cells from damage, is useful in the prevention of diabetes, and generally acts as an anti-aging natural compound. It was highlighted that RSV could ameliorate the consequences of an unhealthy lifestyle caused by an exaggerated caloric intake. This paper reviews the evidence supporting the beneficial effect of RSV for various pathological conditions, e.g., neoplastic diseases, neurodegeneration, metabolic syndrome, diabetes, obesity, CVDs, immune diseases, bacterial, viral, and fungal infections. The study also focused on the chromatographic analysis of trans-RSV (tRSV) in Romanian wine samples, providing a comprehensive overview of tRSV content across different types of wine.

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“…As with many other natural compounds, RSV exerts a biphasic effect. Indeed, several studies have demonstrated that high doses of RSV lead to a decline in cell viability, while low doses could determine a proliferative effect [ 48 , 49 ]. Rocha et al investigated the effect of RSV from 25 to 500 µM, for 24 h, against immortalized fibroblasts (HaCaT cell lines).…”

Section: In Vitro and In Vivo Chemopreventive And Anticancer Activiti...mentioning

confidence: 99%

Chemopreventive and Anticancer Role of Resveratrol against Oral Squamous Cell Carcinoma

et al. 2023

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Oral squamous cell carcinoma (OSCC) is one of the most prevailing and aggressive head and neck cancers, featuring high morbidity and mortality. The available conventional treatments suffer from several adverse effects and are often inefficient in terms of their survival rates. Thus, seeking novel therapeutic agents and adjuvants is of the utmost importance for modern society. Natural polyphenolic compounds have recently emerged as promising chemopreventive and anticancer agents. Specifically, the natural compound resveratrol (RSV) has recently gained momentum for this purpose. RSV is useful for treating OSCC due to its antiproliferative, antimetastatic, and proapoptotic effects. Additionally, RSV acts against tumor cells while synergically cooperating with chemotherapeutics, overcoming drug resistance phenomena. Despite these wide-spectrum effects, there are few specific investigations regarding RSV’s effects against OSCC animal models that consider different routes and vehicles for the administration of RSV. Interestingly, an injectable RSV-loaded liposome-based formulation was proven to be effective against both in vitro and in vivo OSCC models, demonstrating that the development of RSV-loaded drug delivery systems for systemic and/or loco-regional applications may be the turning point in oral cancer treatment, leading to benefits from both RSV’s properties as well as from targeted delivery. Given these premises, this review offers a comprehensive overview of the in vitro and in vivo effects of RSV and its main derivative, polydatin (PD), against OSCC-related cell lines and animal models, aiming to guide the scientific community in regard to RSV and PD use in the treatment of oral precancerous and cancerous lesions.

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Emerging Effects of Resveratrol on Wound Healing: A Comprehensive Review

Cited by 13 publications

References 80 publications

Bitter Phytochemicals as Novel Candidates for Skin Disease Treatment

Bitter Phytochemicals as Novel Candidates for Skin Disease Treatment

Resveratrol: A Review on the Biological Activity and Applications

Chemopreventive and Anticancer Role of Resveratrol against Oral Squamous Cell Carcinoma

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