Emerging evidence-based innovative approaches to control catheter-associated urinary tract infection: a review

Abstract

Healthcare settings have dramatically advanced the latest medical devices, such as urinary catheters (UC) for infection, prevention, and control (IPC). The continuous or intermittent flow of a warm and conducive (urine) medium in the medical device, the urinary catheter, promotes the formation of biofilms and encrustations, thereby leading to the incidence of CAUTI. Additionally, the absence of an innate immune host response in and around the lumen of the catheter reduces microbial phagocytosis and drug action. Hence, the review comprehensively overviews the challenges posed by CAUTI and associated risks in patients’ morbidity and mortality. Also, detailed, up-to-date information on the various strategies that blended/tailored the surface properties of UC to have anti-fouling, biocidal, and anti-adhesive properties to provide an outlook on how they can be better managed with futuristic solutions.

Resveratrol-Encapsulated Glutathione-Modified Robust Mesoporous Silica Nanoparticles as an Antibacterial and Antibiofilm Coating Agent for Medical Devices

“…Previous literature reports suggested that flagellated bacteria like E. coli can migrate from an infected catheter toward the bladder and reach the kidney via swarming, whereas in the case of S. aureus, it migrates via sliding, which is one form of motility .…”

Continuum Robots and Magnetic Soft Robots: From Models to Interdisciplinary Challenges for Medical Applications

“…These environments may not only be non-uniform, but may also involve the combined effects of multiple magnetic fields. More importantly, in actual surgical applications, it is necessary to consider problems faced by interdisciplinary, such as biofilms [ 189 ] and infections related to catheters [ 190 , 191 ]. Although the literature [ 192 ] proposes a strategy for preventing biological infections, it still confronts multiple challenges [ 193 ].…”

Medical Scope of Biofilm and Quorum Sensing during Biofilm Formation: Systematic Review

“…In contrast to an acute wound, which is typically unrelated to biofilm, a chronic wound caused by biofilm endures and heals slowly. Although P. aeruginosa biofilms are embedded in the deep layers of wounds, biofilms typically grow on the outer layer of wounds and are challenging to diagnose using a standard wound swab culture [53,54].…”