Emerging evidence that ginseng components improve cognition in subjective memory impairment, mild cognitive impairment, and early Alzheimer's disease dementia

Lee, Rami; Kim, Ji-Hun; Kim, Won-Woo; Hwang, Sung-Hee; Choi, Sun-Hye; Kim, Jong-Hoon; Cho, Ik-Hyun; Kim, Manho; Nah, Seung-Yeol

doi:10.1016/j.jgr.2024.02.002

Cited by 5 publications

(1 citation statement)

References 65 publications

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“…The third stage is the dementia stage, where SMI and MCI become AD over time without proper management or treatment. AD includes a variety of behavioral changes, including memory impairment, difficulty remembering names and phone numbers, language difficulties, decreased visual and spatial abilities, and emotional changes [ 8 , 9 ]. Currently, there are no effective pharmaceutical treatments for AD (i.e., treatments that have been proven to alter the underlying disease pathology or disease process) [ 4 ].…”

Section: Introductionmentioning

confidence: 99%

Efficacy and Safety of Panax ginseng Sprout Extract in Subjective Memory Impairment: A Randomized, Double-Blind, Placebo-Controlled Clinical Trial

Baek,

Ha,

Park

et al. 2024

Nutrients

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Sprout ginseng extract (ThinkGIN™) manufactured through a smart farm system has been shown to improve memory in preclinical studies. This study conducted a 12-week randomized, double-blind, placebo-controlled clinical trial to evaluate the efficacy and safety of ThinkGIN™ for improving memory in subjective memory impairment (SMI). Subjects aged 55 to 75 years with SMI participated in this study. A total of 80 subjects who met the inclusion/exclusion criteria were assigned to the ThinkGIN™ group (n = 40, 450 mg ThinkGIN™/day) or a placebo group (n = 40). Efficacy and safety evaluations were conducted before intervention and at 12 weeks after intervention. As a result of 12 weeks of ThinkGIN™ intake, significant differences in SVLT, RCFT, MoCA-K, PSQI-K, and AChE were observed between the two groups. Safety evaluation (AEs, laboratory tests, vital signs, and electrocardiogram) revealed that ThinkGIN™ was safe with no clinically significant changes. Therefore, ThinkGIN™ has the potential to be used as a functional food to improve memory.

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Section: Introductionmentioning

confidence: 99%