Emerging Infectious Diseases

McArthur, Donna Behler

doi:10.1016/j.cnur.2019.02.006

Cited by 141 publications

(104 citation statements)

References 22 publications

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“…Over the past three and half decades at least 30 new infectious agents affecting humans have emerged including SARS-CoV-2, and most of them are zoonotic. It was also reported that 61 % infectious organisms affecting humans are zoonotic diseases which can infect both human and animals (Nii-Trebi, 2017;McArthur, 2019). Previous studies have revealed that both SARS-CoV-1 and MERS-CoV originated in bats (Lau et al, 2010;Guan et al, 2003;Lau et al, 2005;Li et al, 2005), with SARS-CoV-1 jumping to humans from palm civets (Song et al, 2005;Chinese, 2004;Wang et al, 2005) and MERS-CoV jumping to humans from camels (Muller et al, 2014;Chu et al, 2014) following intermediate transmission from bats (Lau et al, 2010;Guan et al, 2003;Lau et al, 2005;Li et al, 2005).…”

Section: Introductionmentioning

confidence: 99%

Phylogenetic and phylodynamic analyses of SARS-CoV-2

Nie¹,

Chen³

et al. 2020

Virus Research

101

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To investigate the evolutionary and epidemiological dynamics of the current COVID-19 outbreak, a total of 112 genomes of SARS-CoV-2 strains sampled from China and 12 other countries with sampling dates between 24 December 2019 and 9 February 2020 were analyzed. We performed phylogenetic, split network, likelihoodmapping, model comparison, and phylodynamic analyses of the genomes. Based on Bayesian time-scaled phylogenetic analysis with the best-fitting combination models, we estimated the time to the most recent common ancestor (TMRCA) and evolutionary rate of SARS-CoV-2 to be

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Section: Introductionmentioning

confidence: 99%

Phylogenetic and phylodynamic analyses of SARS-CoV-2

Nie¹,

Chen³

et al. 2020

Virus Research

101

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“…The incidence of zoonotic diseases increases when humans live in close contact with animals, such as when both hosts overlap in a geographic region [117]. Thus, it is important to consider humans together with animals and the environment as a whole, which is emphasized in the One Health Strategy, in order to prevent and control the emergence of zoonotic diseases.…”

Section: Does Onchocerciasis Have a Zoonotic Character?mentioning

confidence: 99%

“…Thus, it is important to consider humans together with animals and the environment as a whole, which is emphasized in the One Health Strategy, in order to prevent and control the emergence of zoonotic diseases. Emerging zoonotic diseases impact on public health and socioeconomic aspects of the global population [117].…”

Section: Does Onchocerciasis Have a Zoonotic Character?mentioning

confidence: 99%

Zoonotic Implications of Onchocerca Species on Human Health

et al. 2020

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The genus Onchocerca includes several species associated with ungulates as hosts, although some have been identified in canids, felids, and humans. Onchocerca species have a wide geographical distribution, and the disease they produce, onchocerciasis, is generally seen in adult individuals because of its large prepatency period. In recent years, Onchocerca species infecting animals have been found as subcutaneous nodules or invading the ocular tissues of humans; the species involved are O. lupi, O. dewittei japonica, O. jakutensis, O. gutturosa, and O. cervicalis. These findings generally involve immature adult female worms, with no evidence of being fertile. However, a few cases with fertile O. lupi, O. dewittei japonica, and O. jakutensis worms have been identified recently in humans. These are relevant because they indicate that the parasite’s life cycle was completed in the new host—humans. In this work, we discuss the establishment of zoonotic Onchocerca infections in humans, and the possibility of these infections to produce symptoms similar to human onchocerciasis, such as dermatitis, ocular damage, and epilepsy. Zoonotic onchocerciasis is thought to be an emerging human parasitic disease, with the need to take measures such as One Health Strategies, in order to identify and control new cases in humans.

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“…Virus transmission is performed by mosquito vector, with predominance of the genus Aedes (Bhatt et al, 2013). Like other emerging infectious diseases, outbreaks of the DENV are unpredictable and potentially widespread, and can result in epidemics that threaten global public health (Fauci and Morens, 2012;Morens and Fauci, 2013;McArthur, 2019). The disease is endemic in over 120 countries, which account for 3.9 billion people at risk of infection worldwide (World Health Organization, 2020).…”

Section: Introductionmentioning

confidence: 99%

Efficient Plant Production of Recombinant NS1 Protein for Diagnosis of Dengue

et al. 2020

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Dengue fever is endemic in more than 120 countries, which account for 3.9 billion people at risk of infection worldwide. The absence of a vaccine with effective protection against the four serotypes of this virus makes differential molecular diagnosis the key step for the correct treatment of the disease. Rapid and efficient diagnosis prevents progression to a more severe stage of this disease. Currently, the limiting factor in the manufacture of dengue (DENV) diagnostic kits is the lack of large-scale production of the non-structural 1 (NS1) protein (antigen) to be used in the capture of antibodies from the blood serum of infected patients. In this work, we use plant biotechnology and genetic engineering as tools for the study of protein production for research and commercial purposes. Gene transfer, integration and expression in plants is a valid strategy for obtaining large-scale and low-cost heterologous protein production. The authors produced NS1 protein of the dengue virus serotype 2 (NS1DENV2) in the Arabidopsis thaliana plant. Transgenic plants obtained by genetic transformation expressed the recombinant protein that was purified and characterized for diagnostic use. The yield was 203 µg of the recombinant protein per gram of fresh leaf. By in situ immunolocalization, transgenic protein was observed within the plant tissue, located in aggregates bodies. These antigens showed high sensitivity and specificity to both IgM (84.29% and 91.43%, respectively) and IgG (83.08% and 87.69%, respectively). The study goes a step further to validate the use of plants as a strategy for obtaining large-scale and efficient protein production to be used in dengue virus diagnostic tests.

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Emerging Infectious Diseases

Cited by 141 publications

References 22 publications

Phylogenetic and phylodynamic analyses of SARS-CoV-2

Phylogenetic and phylodynamic analyses of SARS-CoV-2

Zoonotic Implications of Onchocerca Species on Human Health

Efficient Plant Production of Recombinant NS1 Protein for Diagnosis of Dengue

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