Emerging Insights into the Metabolic Alterations in Aging Using Metabolomics

Srivastava, Sarika

doi:10.3390/metabo9120301

Cited by 92 publications

(83 citation statements)

References 126 publications

(177 reference statements)

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“…Blood comprises cellular and non-cellular components: Red blood cells (RBCs), white blood cells (WBCs), platelets, and plasma. Many studies on blood have been conducted on plasma or serum, the non-cellular component [ 47 , 48 ]. One reason is the difficulty in handling cell-derived metabolites so as to promote their stability [ 49 ].…”

Section: Metabolomic Approach For Human Whole Bloodmentioning

confidence: 99%

Whole Blood Metabolomics in Aging Research

Kondoh

Kameda

Yanagida

2020

IJMS

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Diversity is observed in the wave of global aging because it is a complex biological process exhibiting individual variability. To assess aging physiologically, markers for biological aging are required in addition to the calendar age. From a metabolic perspective, the aging hypothesis includes the mitochondrial hypothesis and the calorie restriction (CR) hypothesis. In experimental models, several compounds or metabolites exert similar lifespan-extending effects, like CR. However, little is known about whether these metabolic modulations are applicable to human longevity, as human aging is greatly affected by a variety of factors, including lifestyle, genetic or epigenetic factors, exposure to stress, diet, and social environment. A comprehensive analysis of the human blood metabolome captures complex changes with individual differences. Moreover, a non-targeted analysis of the whole blood metabolome discloses unexpected aspects of human biology. By using such approaches, markers for aging or aging-relevant conditions were identified. This information should prove valuable for future diagnosis or clinical interventions in diseases relevant to aging.

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Section: Metabolomic Approach For Human Whole Bloodmentioning

confidence: 99%

Whole Blood Metabolomics in Aging Research

Kondoh

Kameda

Yanagida

2020

IJMS

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“…In this sense, it is important to keep in mind that metabolite concentrations change continuously with growth and age, especially with children and infants. This is often not fully realized, due to the fact that the majority of clinical studies that have been published are for adults [49][50][51][52][53][54][55]. Indeed, to date, there have only been a few comprehensive studies looking at age-specific intervals in children [48,56,57] and newborns [30].…”

Section: The Importance Of Age-specific Intervalsmentioning

confidence: 99%

The Urinary Metabolome of Healthy Newborns

et al. 2020

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The knowledge of normal metabolite values for neonates is key to establishing robust cut-off values to diagnose diseases, to predict the occurrence of new diseases, to monitor a neonate's metabolism, or to assess their general health status. For full term-newborns, many reference biochemical values are available for blood, serum, plasma and cerebrospinal fluid. However, there is a surprising lack of information about normal urine concentration values for a large number of important metabolites in neonates. In the present work, we used targeted tandem mass spectrometry (MS/MS)-based metabolomic assays to identify and quantify 136 metabolites of biomedical interest in the urine from 48 healthy, full-term term neonates, collected in the first 24 h of life. In addition to this experimental study, we performed a literature review (covering the past eight years and over 500 papers) to update the references values in the Human Metabolome Database/Urine Metabolome Database (HMDB/UMDB). Notably, 86 of the experimentally measured urinary metabolites are being reported in neonates/infants for the first time and another 20 metabolites are being reported in human urine for the first time ever. Sex differences were found for 15 metabolites. The literature review allowed us to identify another 78 urinary metabolites with concentration data. As a result, reference concentration values and ranges for 378 neonatal urinary metabolites are now publicly accessible via the HMDB.

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“…The metabolome may be investigated using NMR or MS to profile known metabolites or may be used for the discovery and characterization of unknown metabolites. 154 Despite its usefulness in characterizing known and novel metabolic pathways, a major caveat in metablomics is the snapshot nature of profiling metabolites. Similar to a cross-sectional study in its design, 155 metabolomic investigations run the risk of over interpretation of data, even in a time-series design, 156 leading to assumptions about metabolic flux.…”

Section: Future Are a S In T Cell Immunome Tabolis Mmentioning

confidence: 99%

“…Collectively, these molecules and their interactions within a biologic system are branded as the metabolome. The metabolome may be investigated using NMR or MS to profile known metabolites or may be used for the discovery and characterization of unknown metabolites 154 . Despite its usefulness in characterizing known and novel metabolic pathways, a major caveat in metablomics is the snapshot nature of profiling metabolites.…”

Section: Future Areas In T Cell Immunometabolismmentioning

confidence: 99%

Chemical individuality in T cells: A Garrodian view of immunometabolism

McGuire

2020

Immunological Reviews

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Metabolically quiescent T cells circulate throughout the body in search of antigen.Following engagement of their cognate receptors, T cells undergo metabolic reprogramming to support their activation, differentiation, and ultimately function. In the spirit of Sir Archibald Garrod, this metabolic reprogramming actually imparts a chemical individuality which confers advantage, while in others confers vulnerability, depending upon the milieu. Studying T cell immunometabolism in the context of inborn errors of metabolism allows one to define essential pathways of intermediary metabolism as well metabolic vulnerabilities and plasticity. Inborn errors of metabolism, a class of diseases first named by Garrod, have a long history of being informative for common physiologic and pathologic processes. This endeavor may be accomplished through the study of patients, animal models, and in vitro models of inborn errors of metabolism. In this review, the basics of intermediary metabolism and core metabolic pathways will be discussed, along with their relationship to T cell immunometabolism.Due to their pleiotropic nature, the reader will be specifically directed toward various inborn errors of metabolism which may be helpful for answering important questions about the role of metabolism in T cells. K E Y W O R D Simmunometabolism, inborn errors of metabolism, T cells

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Emerging Insights into the Metabolic Alterations in Aging Using Metabolomics

Cited by 92 publications

References 126 publications

Whole Blood Metabolomics in Aging Research

Whole Blood Metabolomics in Aging Research

The Urinary Metabolome of Healthy Newborns

Chemical individuality in T cells: A Garrodian view of immunometabolism

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