Emerging insights on drug delivery by fatty acid mediated synthesis of lipophilic prodrugs as novel nanomedicines

Fattahi, Nadia; Shahbazi, Mohammad‐Ali; Maleki, Aziz; Hamidi, Mehrdad; Ramazani, Ali; Santos, Hélder A.

doi:10.1016/j.jconrel.2020.07.012

Cited by 64 publications

(54 citation statements)

References 288 publications

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“…The stability of liposomal systems was estimated by the spontaneous release of the entrapped 5(6)-carboxyfluorescein from liposomes. The introduction of 1 and 2 in the phospholipid bilayer decreases the rate of carboxyfluorescein release into the external environment by 2 times and liposome stabilization increases with an increase in the concentration of calix [4]resorcinols. The key role in the stabilizing effect of calix [4]resorcinols 1, 2 is related to the presence of hydroxyl groups in the structure capable of hydrogen bonding with the head groups of phospholipids.…”

Section: Lipid Formulations: Modification With Macrocycles (Cyclodextrins Calixarenes and Porphyrins)mentioning

confidence: 99%

“…The introduction of 1 and 2 in the phospholipid bilayer decreases the rate of carboxyfluorescein release into the external environment by 2 times and liposome stabilization increases with an increase in the concentration of calix [4]resorcinols. The key role in the stabilizing effect of calix [4]resorcinols 1, 2 is related to the presence of hydroxyl groups in the structure capable of hydrogen bonding with the head groups of phospholipids. The embedment of cavitand 3 that does not contain hydroxyl groups, on the contrary, destabilizes the liposomal system.…”

Section: Lipid Formulations: Modification With Macrocycles (Cyclodextrins Calixarenes and Porphyrins)mentioning

confidence: 99%

“…Сalixarenes having hydroxyl groups, as well as CDs, are capable of forming hydrogen bonds with phospholipids, thereby stabilizing the liposomal system. In [126] calix [4]resorcinols 1, 2 and calix [4]resorcinol cavitand 3 (Figure 6) were embedded in liposomes prepared from POPC. The stability of liposomal systems was estimated by the spontaneous release of the entrapped 5(6)-carboxyfluorescein from liposomes.…”

Section: Lipid Formulations: Modification With Macrocycles (Cyclodextrins Calixarenes and Porphyrins)mentioning

confidence: 99%

“…A powerful tool for engineering the formulated medicines is their conjugation with functional ligands, thereby producing prodrugs with beneficial characteristics. For this purpose, polyethylene glycol (PEG), peptides and amphiphilic molecules are used [4][5][6][7][8], which allow modifying pharmacokinetics, toxicity, targeting properties, stimuli responsibility and other effects. Alternatively, encapsulation techniques are used, which provide effective facilities for the design of drug delivery systems.…”

Section: Introductionmentioning

confidence: 99%

See 3 more Smart Citations

Nanocarriers for Biomedicine: From Lipid Formulations to Inorganic and Hybrid Nanoparticles

Kashapov

Ibragimova

Pavlov

et al. 2021

IJMS

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Encapsulation of cargoes in nanocontainers is widely used in different fields to solve the problems of their solubility, homogeneity, stability, protection from unwanted chemical and biological destructive effects, and functional activity improvement. This approach is of special importance in biomedicine, since this makes it possible to reduce the limitations of drug delivery related to the toxicity and side effects of therapeutics, their low bioavailability and biocompatibility. This review highlights current progress in the use of lipid systems to deliver active substances to the human body. Various lipid compositions modified with amphiphilic open-chain and macrocyclic compounds, peptide molecules and alternative target ligands are discussed. Liposome modification also evolves by creating new hybrid structures consisting of organic and inorganic parts. Such nanohybrid platforms include cerasomes, which are considered as alternative nanocarriers allowing to reduce inherent limitations of lipid nanoparticles. Compositions based on mesoporous silica are beginning to acquire no less relevance due to their unique features, such as advanced porous properties, well-proven drug delivery efficiency and their versatility for creating highly efficient nanomaterials. The types of silica nanoparticles, their efficacy in biomedical applications and hybrid inorganic-polymer platforms are the subject of discussion in this review, with current challenges emphasized.

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Section: Lipid Formulations: Modification With Macrocycles (Cyclodextrins Calixarenes and Porphyrins)mentioning

confidence: 99%

Section: Lipid Formulations: Modification With Macrocycles (Cyclodextrins Calixarenes and Porphyrins)mentioning

confidence: 99%

Section: Lipid Formulations: Modification With Macrocycles (Cyclodextrins Calixarenes and Porphyrins)mentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Nanocarriers for Biomedicine: From Lipid Formulations to Inorganic and Hybrid Nanoparticles

Kashapov

Ibragimova

Pavlov

et al. 2021

IJMS

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show abstract

“…Copper(I) complexes including diimine ligands with water-solubilizing groups have also been examined for their in vitro anticancer potential against human tumor cell lines, exhibiting moderate to high cytotoxic activities and with potential to overcome cisplatin resistant cell lines [17]. Other strategies employed to improve the delivery of chemotherapy include functionalization of the drug with ester or carboxylic acid moieties [18][19][20], assembling pH-or temperature-responsive multilayer polymers encapsulating drugs [21][22][23], and encapsulating drugs in nanosheets [24] or metal-organic frameworks [25].…”

Section: Introductionmentioning

confidence: 99%

Effect of Net Charge on DNA-Binding, Protein-Binding and Anticancer Properties of Copper(I) Phosphine-Diimine Complexes

Alsaedi

Babgi

Abdellatif

et al. 2021

J Inorg Organomet Polym

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The syntheses of [Cu(PPh3)2(L)]NO3 and [Cu(PPh3)2(L-SO3Na)]NO3 were achieved through the reaction of Cu(PPh3)2NO3 and equimolar amount of the ligands (L = 5,6-diphenyl-3-[2-pyridyl]-1,2,4-triazine; LSO3Na = 5,6-diphenyl-3-[2-pyridyl]-1,2,4-triazine-4,4′-disulfonic acid disodium salt). The complexes were characterized by NMR and IR spectroscopy and mass spectrometry. The compounds exhibit similar absorption and emission spectra, suggesting a similar electronic structure. Ct-DNA binding studies show the strong influence of the net charge as Cu-L (positively charged) is able to bind to ct-DNA while Cu-LSO3Na (negatively charged) is not. The net charge of the complexes affects the thermodynamic and kinetic binding parameters toward human serum albumin. HSA-binding of the complexes was further investigated by molecular docking, revealing different binding sites on the HSA protein as a function of the net charge. The different anticancer activities of the complexes towards ovcar-3 and hope-62 cancer cell lines are suggestive of a role for the overall charge of the complexes. Interaction with the DNA is not the major mechanism for this class of complexes. The overall net charge of the pharmacophore (anticancer agent) should be a key consideration in the design of anticancer metal complexes.

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Nanodiamonds as Next Generation Carriers in Exploring Therapeutic Benefits

Fattahi

Ramazani

2023

Advances in Material Research and Technology

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Emerging insights on drug delivery by fatty acid mediated synthesis of lipophilic prodrugs as novel nanomedicines

Cited by 64 publications

References 288 publications

Nanocarriers for Biomedicine: From Lipid Formulations to Inorganic and Hybrid Nanoparticles

Nanocarriers for Biomedicine: From Lipid Formulations to Inorganic and Hybrid Nanoparticles

Effect of Net Charge on DNA-Binding, Protein-Binding and Anticancer Properties of Copper(I) Phosphine-Diimine Complexes

Nanodiamonds as Next Generation Carriers in Exploring Therapeutic Benefits

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