Emerging Internet of Things driven carbon nanotubes-based devices

Zhang, Shu; Pang, Jinbo; Li, Yufen; Yang, Feng; Gemming, Thomas; Wang, Kai; Wang, Xiao; Peng, Songang; Liu, Xiaoyan; Chang, Bin; Liu, Hong; Zhou, Weijia; Cuniberti, Gianaurelio; Rümmeli, Mark H.

doi:10.1007/s12274-021-3986-7

Cited by 26 publications

(21 citation statements)

References 384 publications

(401 reference statements)

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“…In recent years, a lot of new diagnostic methods have emerged. Among them, volatolomics is one of the more valuable ones that may be used as a new development direction of future diagnostics [12][13][14], which is the non-invasive detection of volatile organic compounds (VOCs) emitted from patients.…”

Section: Introductionmentioning

confidence: 99%

Volatolomics in healthcare and its advanced detection technology

Jian

et al. 2022

Nano Res.

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Various diseases increasingly challenge the health status and life quality of human beings. Volatolome emitted from patients has been considered as a potential family of markers, volatolomics, for diagnosis/screening. There are two fundamental issues of volatolomics in healthcare. On one hand, the solid relationship between the volatolome and specific diseases needs to be clarified and verified. On the other hand, effective methods should be explored for the precise detection of volatolome. Several comprehensive review articles had been published in this field. However, a timely and systematical summary and elaboration is still desired. In this review article, the research methodology of volatolomics in healthcare is critically considered and given out, at first. Then, the sets of volatolome according to specific diseases through different body sources and the analytical instruments for their identifications are systematically summarized. Thirdly, the advanced electronic nose and photonic nose technologies for volatile organic compounds (VOCs) detection are well introduced. The existed obstacles and future perspectives are deeply thought and discussed. This article could give a good guidance to researchers in this interdisciplinary field, not only understanding the cutting-edge detection technologies for doctors (medicinal background), but also making reference to clarify the choice of aimed VOCs during the sensor research for chemists, materials scientists, electronics engineers, etc.

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Section: Introductionmentioning

confidence: 99%

Volatolomics in healthcare and its advanced detection technology

Jian

et al. 2022

Nano Res.

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“…Antibodies, enzymes, nucleic acid, aptamers, and molecularly imprinted polymers are some of the biomolecules used for the detection of target molecules. The advantage of antibodies over other biorecognition elements such as DNA and aptamers are lower cost, high affinity, highly stable, ease of functionalization, immobilization on different sensing elements such as graphene, and their capability to bind to a target, in different physiological conditions of clinical samples. , In addition to that, several advanced nanomaterials such as gold nanoparticles, iron oxide nanoparticles, organogels, and carbon nanotubes, − graphene have proven to be superior conductive materials to enhance the sensitivity of biosensors. , Graphene is a hexagonal two-dimensional (2D) material that has outperformed other nanomaterials in the construction of sensitive biosensors. − Due to their immense potential, graphene-based FETs are successfully employed for the development of various diagnostic platforms. − …”

Section: Introductionmentioning

confidence: 99%

Graphene-Based Field-Effect Transistor for Ultrasensitive Immunosensing of SARS-CoV-2 Spike S1 Antigen

Shahdeo

Chauhan

Majumdar

et al. 2022

ACS Appl. Bio Mater.

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Coronavirus disease (COVID-19) is an infectious disease that has posed a global health challenge caused by the SARS-CoV-2 virus. Early management and diagnosis of SARS-CoV-2 are crucial for the timely treatment, traceability, and reduction of viral spread. We have developed a rapid method using a Graphene-based Field-Effect Transistor (Gr-FET) for the ultrasensitive detection of SARS-CoV-2 Spike S1 antigen (S1-Ag). The in-house developed antispike S1 antibody (S1-Ab) was covalently immobilized on the surface of a carboxy functionalized graphene channel using carbodiimide chemistry. Ultraviolet–visible spectroscopy, Fourier-Transform Infrared Spectroscopy, X-ray Photoelectron Spectroscopy (XPS), Atomic Force Microscopy (AFM), Optical Microscopy, Raman Spectroscopy, Scanning Electron Microscopy (SEM), Enzyme-Linked Immunosorbent Assays (ELISA), and device stability studies were conducted to characterize the bioconjugation and fabrication process of Gr-FET. In addition, the electrical response of the device was evaluated by monitoring the change in resistance caused by Ag–Ab interaction in real time. For S1-Ag, our Gr-FET devices were tested in the range of 1 fM to 1 μM with a limit of detection of 10 fM in the standard buffer. The fabricated devices are highly sensitive, specific, and capable of detecting low levels of S1-Ag.

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“…The MXene-based devices are mainly designed for individual functions, e.g., sensors [97,385], memories or data processors, and power units such as batteries and supercapacitors [386]. First, the individual device should break the theoretical limit for higher performances [387]. The integration of microfluidic chips and chemiresistor results in biosensors of good selectivity [120].…”

Section: Conclusion and Future Opportunitiesmentioning

confidence: 99%

Applications of MXenes in human-like sensors and actuators

et al. 2022

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Human beings perceive the world through the senses of sight, hearing, smell, taste, touch, space, and balance. The first five senses are prerequisites for people to live. The sensing organs upload information to the nervous systems, including the brain, for interpreting the surrounding environment. Then, the brain sends commands to muscles reflexively to react to stimuli, including light, gas, chemicals, sound, and pressure. MXene, as an emerging two-dimensional material, has been intensively adopted in the applications of various sensors and actuators. In this review, we update the sensors to mimic five primary senses and actuators for stimulating muscles, which employ MXene-based film, membrane, and composite with other functional materials. First, a brief introduction is delivered for the structure, properties, and synthesis methods of MXenes. Then, we feed the readers the recent reports on the MXene-derived image sensors as artificial retinas, gas sensors, chemical biosensors, acoustic devices, and tactile sensors for electronic skin. Besides, the actuators of MXene-based composite are introduced. Eventually, future opportunities are given to MXene research based on the requirements of artificial intelligence and humanoid robot, which may induce prospects in accompanying healthcare and biomedical engineering applications.

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Emerging Internet of Things driven carbon nanotubes-based devices

Cited by 26 publications

References 384 publications

Volatolomics in healthcare and its advanced detection technology

Volatolomics in healthcare and its advanced detection technology

Graphene-Based Field-Effect Transistor for Ultrasensitive Immunosensing of SARS-CoV-2 Spike S1 Antigen

Applications of MXenes in human-like sensors and actuators

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