Emerging investigator series: deposited particles and human lung lining fluid are dynamic, chemically-complex reservoirs leading to thirdhand smoke emissions and exposure

Abstract

Tobacco combustion products in deposited particles and bodily reservoirs enable persistent thirdhand smoke contamination and transport.

Secondary Brown Carbon Formation From Photooxidation of Furans From Biomass Burning

“…Biomass burning SOA has been proposed to largely originate from the oxidation of understudied VOCs such as phenols or furans (Akherati et al., 2020; Bruns et al., 2016; Hatch et al., 2017). Furans are a major class of heterocyclic compounds in biomass burning emissions that are generated from pyrolysis of cellulose (Ciccioli et al., 2001; Gilman et al., 2015; Hatch et al., 2017; Mettler et al., 2012) and are prevalent in other environments (e.g., tobacco smoke and indoor air) (Sheu et al., 2021, 2022). This class of compounds is highly reactive with atmospheric oxidants and can produce high yields of carbonyls that can further react to form BrC in the presence of ammonium (Aschmann et al., 2014; De Haan et al., 2020; Decker et al., 2019; Gómez Alvarez et al., 2009; Jiang, Tsona, et al., 2019; Koss et al., 2018; Laskin et al., 2015; Lee et al., 2013; Updyke et al., 2012).…”

“…and are prevalent in other environments (e.g., tobacco smoke and indoor air) (Sheu et al, 2021(Sheu et al, , 2022. This class of compounds is highly reactive with atmospheric oxidants and can produce high yields of carbonyls that can further react to form BrC in the presence of ammonium (Aschmann et al, 2014;De Haan et al, 2020;Decker et al, 2019;Gómez Alvarez et al, 2009;Jiang, Tsona, et al, 2019;Koss et al, 2018;Lee et al, 2013;Updyke et al, 2012).…”

Temporal changes in thirdhand cigarette smoke film composition and oxidation of co-existing surface film chemicals

“…19 If the condensed phase is aqueous, it has been observed that Henry's Law can describe both uptake and off-gassing, for instance from simulated lung lining uid. 44 Therefore, the chemical composition of THS lms controls the supply of tobacco-related SVOCs to the gas phase over long periods of time in THS contaminated environments. 16,19,20,45 Chemical characterization of fresh cigarette smoke has been widely conducted and thoroughly documented.…”

“…The composition, viscosity, and porosity of the substrate material has been implicated in the partitioning behaviour of compounds found in THS. 44 In this study, we intend to show that exposure of surfaces to sidestream cigarette smoke can induce oxidation in surface films, altering their composition to produce various oxidation products, including hydroperoxides. A non-volatile antioxidant (tris(2-carboxyethyl)phosphine; TCEP) was used to demonstrate oxidative action of THS films.…”

“…16,19,20,45 Chemical characterization of fresh cigarette smoke has been widely conducted and thoroughly documented. 46 While studies have sought to perform broad chemical characterizations of THS lms 44 and gases, 16,44 along with the consequences of multiphase chemistry on THS lms, 25,26,39,42 reactive processes that are endogenous to condensed-phase THS have not garnered focus. It has been known for decades that freshly collected cigarette smoke exhibits a persistent free radical character, which likely involves semiquinones associated with (mono-and poly-) aromatic compounds in cigarette smoke.…”