Emerging issues: the effects of endocrine disrupters on reproductive development

GrayJr, L. Earl; Monosson, Emily; Kelce, William R.

doi:10.1007/978-94-009-1523-7_4

Cited by 22 publications

(18 citation statements)

References 109 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In vitro and in vivo studies in terrestrial mammals, primarily rodents, have shown that organochlorines, including PCBs and DDE, are potential estrogenic endocrine disruptors [221][222][223][224][225]. In vitro and in vivo studies in terrestrial mammals, primarily rodents, have shown that organochlorines, including PCBs and DDE, are potential estrogenic endocrine disruptors [221][222][223][224][225].…”

Section: Mammalsmentioning

confidence: 99%

Gender Benders at the Beach: Endocrine Disruption in Marine and Estuarine Organisms

Oberdörster¹,

Cheek²

2001

Environ Toxicol Chem

View full text Add to dashboard Cite

Several consensus definitions of the term endocrine disruptor have appeared recently, but all definitions include the important, though frequently implicit, stipulation that the animal is not distressed or in obvious discomfort. Instead, a superficially healthy animal is experiencing alterations in hormone synthesis, transport, receptor interaction, metabolism, excretion, or feedback regulation. In addition, hormone disruption may occur during sex differentiation, and its effects may not be manifested until after sexual maturation. Many cases of chemically induced reproductive impairment have been reported for both freshwater and marine species. However, reproductive impairment may not necessarily result from hormone disruption and should be considered suggestive, but not conclusive, evidence of endocrine disruption. A suite of in vivo and in vitro assays will more adequately assess whether a compound is truly endocrine disrupting. This review will cover basic endocrinology of marine and estuarine invertebrates and vertebrates, methods for detecting endocrine disruption, and examples of endocrine disruption in various species.

show abstract

Section: Mammalsmentioning

confidence: 99%

Gender Benders at the Beach: Endocrine Disruption in Marine and Estuarine Organisms

Oberdörster¹,

Cheek²

2001

Environ Toxicol Chem

View full text Add to dashboard Cite

show abstract

“…Most of these estrogenic xenobiotics are considered to exert their estrogenic effects primarily by binding to nuclear estrogen receptors (Gray et al, 1996;Tomas & Khan, 1997). Endocrine disruptors include industrial chemicals like pesticides, polychlorinated biphenyls (PCBs), dioxin, and other synthetic chemicals.…”

Section: Introductionmentioning

confidence: 99%

Dioxin exposure and porcine reproductive hormonal activity

Gregoraszczuk

2002

Cad. Saúde Pública

View full text Add to dashboard Cite

show abstract

“…Importantly, these chemicals, when combined, exhibit additivity or greater than additivity in the estrogen receptor competitive bindings assays [Vonier et al, 1996]. Affinity for a receptor does not guarantee that a contaminant has a steroid mimicking effect, as it could equally act as a hormone antagonist [Kelce et al, 1995;Gray et al, 1996]. Experimental testing of these compounds for endocrine disrupting ability is required to further examine these hypotheses.…”

Section: Sexual Determination and Differentiation As Markers Of Envirmentioning

confidence: 99%

Gonadal Differentiation in Reptiles Exhibiting Environmental Sex Determination

Kohno¹,

Parrott²,

Yatsu³

et al. 2014

Sex Dev

View full text Add to dashboard Cite

As temperature-dependent sex determination (TSD) and homozygote or heterozygote genetic sex determination (GSD) exist in multiple reptilian taxa, they represent sex determination systems that have emerged de novo. Current investigations have revealed that the genetic mechanisms used by various reptilian species are similar to those used by other vertebrates. However, the recent completion or near completion of various reptilian genome projects suggests that new studies examining related species with and without TSD could begin to provide additional insight into the evolution of TSD and GSD in vertebrate ancestors. Major questions still remain concerning germ cell migration and specification, the differentiation of gonadal accessory cells, such as the Sertoli cells and granulosa cells of the developing testis and ovary, respectively, and the mechanisms by which gene expression is regulated during TSD events. Further, reptilian sentinels and their mechanisms of gonadogenesis will likely remain important indicator species for environmental health. Thus, ongoing and new investigations need to tie molecular information to gonadal morphogenesis and function in reptiles. Such data will not only provide important information for an understanding of the evolution of these phenomena in vertebrates, but could also provide an important understanding of the health of the environment around us.

show abstract

Emerging issues: the effects of endocrine disrupters on reproductive development

Cited by 22 publications

References 109 publications

Gender Benders at the Beach: Endocrine Disruption in Marine and Estuarine Organisms

Gender Benders at the Beach: Endocrine Disruption in Marine and Estuarine Organisms

Dioxin exposure and porcine reproductive hormonal activity

Gonadal Differentiation in Reptiles Exhibiting Environmental Sex Determination

Contact Info

Product

Resources

About