Emerging Markers of Atherosclerosis Before and After Bariatric Surgery

Domienik‐Karłowicz, Justyna; Rymarczyk, Zuzanna; Dzikowska-Diduch, Olga; Lisik, Wojciech; Chmura, A.; Demkow, Urszula; Pruszczyk, Piotr

doi:10.1007/s11695-014-1407-7

Cited by 25 publications

(16 citation statements)

References 36 publications

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“…A strong association between obesity and CHF, the adverse effects of obesity on myocardial structure and function, and the adverse effects of obesity on blood vessel homeostasis have been reported previously. These effects are consistent with our finding of a significant reduction in CHF after metabolic surgery.…”

Section: Discussionsupporting

confidence: 56%

“…The longitudinal analysis of individual cardiovascular risk factors after bariatric surgery confirms the beneficial effects of metabolic surgery on known CVD risk factors. Other potential mechanisms for the cardiovascular protection conferred by metabolic surgery involve restoration of a normal adipokine secretory profile and a reduction in systemic inflammation, both of which exert direct beneficial effects on the vascular endothelium . Recent evidence suggests that some of the beneficial effects of metabolic surgery occur promptly after surgery, are independent of weight loss, and may involve the enhanced protective function of HDL in addition to increased HDL levels .…”

Section: Discussionmentioning

confidence: 99%

“…The shortcomings of diet and other lifestyle modifications have led to the emergence of metabolic surgery, which is recognized as the most effective option for achieving significant and lasting weight control. Investigations into the mechanisms of cardiovascular protection afforded by metabolic surgery have revealed a reduction in markers of inflammation and thrombosis, restoration of more favorable adipokine secretory profile, improved endothelial function, reduction in cardiovascular risk factors, restoration of normal metabolism, and improvements in cardiac structure and function …”

Section: Introductionmentioning

confidence: 99%

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Gastric Bypass Surgery Produces a Durable Reduction in Cardiovascular Disease Risk Factors and Reduces the Long‐Term Risks of Congestive Heart Failure

Benotti

Wood

Carey

et al. 2017

JAHA

105

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BackgroundObesity and its association with reduced life expectancy are well established, with cardiovascular disease as one of the major causes of fatality. Metabolic surgery is a powerful intervention for severe obesity, resulting in improvement in comorbid diseases and in cardiovascular risk factors. This study investigates the relationship between metabolic surgery and long‐term cardiovascular events.Methods and ResultsA cohort of Roux‐en‐Y gastric bypass surgery (RYGB) patients was tightly matched by age, body mass index, sex, Framingham Risk Score, smoking history, use of antihypertension medication, diabetes mellitus status, and calendar year with a concurrent cohort of nonoperated control patients. The primary study end points of major cardiovascular events (myocardial infarction, stroke, and congestive heart failure) were evaluated using Cox regression. Secondary end points of longitudinal cardiovascular risk factors were evaluated using repeated‐measures regression. The RYGB and matched controls (N=1724 in each cohort) were followed for up to 12 years after surgery (overall median of 6.3 years). Kaplan–Meier analysis revealed a statistically significant reduction in incident major composite cardiovascular events (P=0.017) and congestive heart failure (0.0077) for the RYGB cohort. Adjusted Cox regression models confirmed the reductions in severe composite cardiovascular events in the RYGB cohort (hazard ratio=0.58, 95% CI=0.42–0.82). Improvements of cardiovascular risk factors (eg, 10‐year cardiovascular risk score, total cholesterol, high‐density lipoprotein, systolic blood pressure, and diabetes mellitus) were observed within the RYGB cohort after surgery.ConclusionsGastric bypass is associated with a reduced risk of major cardiovascular events and the development of congestive heart failure.

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Section: Discussionsupporting

confidence: 56%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Gastric Bypass Surgery Produces a Durable Reduction in Cardiovascular Disease Risk Factors and Reduces the Long‐Term Risks of Congestive Heart Failure

Benotti

Wood

Carey

et al. 2017

JAHA

105

View full text Add to dashboard Cite

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“…Bariatric surgery, an effective technique for the improvement or resolution of obesity associated comorbidities, is associated with an improvement of subclinical atherosclerosis and endothelial function, and with a reduction in cardiovascular risk . Few studies have analysed the changes in serum PON concentration and activity after a surgical intervention for obesity: PON paraoxonase enzymatic activity increased 6 months after the insertion of a Swedish adjustable gastric band in morbidly obese subjects, the serum amyloid A/PON arylesterase activity ratio was reduced 1 year after bariatric surgery, and PON1 levels were increased 6 months postoperatively in morbidly obese children and adolescents who underwent laparoscopic sleeve gastrectomy .…”

Section: Introductionmentioning

confidence: 99%

Increased PON lactonase activity in morbidly obese patients is associated with impaired lipid profile

et al. 2019

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Aims:The paraoxonase-1 (PON1) enzyme could play an important role in the antioxidant capacity of high-density lipoprotein. However, there are no studies which analyse the evolution of the three activities of PON1 (PON arylesterase, PON paraoxonase and PON lactonase) after Roux-en-Y Gastric Bypass (RYGB) in morbidly obese subjects. We analysed the association of PON concentration and activities with the evolution of morbidly obese subjects who underwent RYGB, and its relationship with biochemical variables and different atherogenic indices.Methods: Twenty-seven non-obese and 82 morbidly obese subjects were studied before and 6 months after RYGB.Results: Before RYGB, morbidly obese subjects had a lower PON1 concentration (P < 0.05) and higher PON lactonase activity (P < 0.001) than non-obese subjects, with no differences in PON arylesterase and PON paraoxonase activities. After RYGB, PON1 concentration (P < 0.05) and PON lactonase activity (P < 0.001) decreased with regard to the presurgery state. PON lactonase activity correlated with the atherogenic index of plasma before (r = 0.19, P = 0.047) and after RYGB (r = 0.27, P = 0.035). In different multiple lineal regression analysis models, presurgery PON lactonase activity was associated with total cholesterol (β = 0.909, P < 0.001), LDL (β = 0.632, P = 0.006) and DBP (β = 0.230, P = 0.030) (R 2 = 0.295), postsurgery PON

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“…To the editor: I read with great interest the article by Justyna DomienikKarłowicz et al [1] that assess the emerging biochemical markers of arterial remodeling in female patients with morbid obesity before and after surgical treatment, compared to a control group. I am satisfied with the clear evidence of the reduction in adiponectin, matrix metalloproteinase (MMP)-2, and MMP-9 levels in the obese patients after bariatric surgery.…”

mentioning

confidence: 99%