Emerging Materials, Wearables, and Diagnostic Advancements in Therapeutic Treatment of Brain Diseases

Abstract

Among the most critical health issues, brain illnesses, such as neurodegenerative conditions and tumors, lower quality of life and have a significant economic impact. Implantable technology and nano-drug carriers have enormous promise for cerebral brain activity sensing and regulated therapeutic application in the treatment and detection of brain illnesses. Flexible materials are chosen for implantable devices because they help reduce biomechanical mismatch between the implanted device and brain tissue. Additionally, implanted biodegradable devices might lessen any autoimmune negative effects. The onerous subsequent operation for removing the implanted device is further lessened with biodegradability. This review expands on current developments in diagnostic technologies such as magnetic resonance imaging, computed tomography, mass spectroscopy, infrared spectroscopy, angiography, and electroencephalogram while providing an overview of prevalent brain diseases. As far as we are aware, there hasn’t been a single review article that addresses all the prevalent brain illnesses. The reviewer also looks into the prospects for the future and offers suggestions for the direction of future developments in the treatment of brain diseases.

Schizophrenia - Time to Commit to Policy Change

“…[122][123][124] Although the fundamental importance of relationships between healthcare professionals and patients within care models also means that technological approaches are unlikely to replace existing models entirely; 125 wearable technologies and passive monitoring also show promise in augmenting diagnosis and monitoring disease progression. 126,127 Platforms like Health Outcomes Through Positive Engagement and Self-Empowerment (HOPES), and Mobile Therapeutic Attention for Treatment Resistant Schizophrenia (m-RESIST) are exploring the role of wearable devices in schizophrenia management. 126 Current information mainly comes from small-scale studies showing feasibility from the last 5-years, 126 with approaches like sleep pattern monitoring and real-time autonomic dysregulation tracking.…”

Receptor Targeting Using Copolymer-Modified Gold Nanoparticles for pCMV-Luc Gene Delivery to Liver Cancer Cells In Vitro

“…Due to the interaction between their active amino groups and the negatively charged metal NPs, CS has also developed into a popular polymer coating [12]. The amino groups are protonated in dilute acidic aqueous solutions (pH 6), which increases its solubility [13] and gives CS a high cationic potential and a strong affinity for negatively charged nucleic acids, enabling the formation of ionic complexes [14]. Polyethylene glycol (PEG) is a wildly used polymer in NP formulations for medical applications.…”

Advances in Additive Manufacturing Techniques for Electrochemical Energy Storage

“…Because each membrane electrode assembly (MEA) produces no more than 1 V, they are typically stacked to achieve the required voltage, with each cell split by bipolar plates and gaskets to ensure a tight seal. [39][40][41][42][43] • Fabrication and rapid prototyping of complex architectures with high control accuracy becomes possible. [44] • Precise control of the shape, size, and thickness of the electrodes.…”