Emerging Medical Therapies in Rosacea: A Narrative Review

Choe, James; Barbieri, John S.

doi:10.1007/s13555-023-01048-1

Dermatol Ther (Heidelb)

2023

DOI: 10.1007/s13555-023-01048-1

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Emerging Medical Therapies in Rosacea: A Narrative Review

James Choe,

John S. Barbieri

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2024

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Cited by 4 publications

References 44 publications

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Personalise treatment for rosacea by selecting from a range of options for individual features

Nie

2024

Drugs Ther Perspect

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Personalise treatment for rosacea by selecting from a range of options for individual features

Nie

2024

Drugs Ther Perspect

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Therapeutic strategies focusing on immune dysregulation and neuroinflammation in rosacea

Tu,

Jung,

Shih

et al. 2024

Front. Immunol.

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Rosacea is a complex inflammatory condition characterized by papulopustular lesions and erythema on the central face for which there is no cure. The development of rosacea is influenced by both external triggers and genetics, but the common pathophysiology is overactivation of the immune system. Here, we review the current data on proinflammatory cytokines and dysregulation of the neurovascular system as targetable components of rosacea. Amelioration of cutaneous and gastrointestinal dysbiosis and other external factors impacts the immune state and has been observed to improve rosacea. While multiple treatments exist, many patients do not achieve their goals for rosacea control and highlights an unmet need for dermatologic care. Current interventions encompass topical/oral drugs, light devices, and avoidance of triggers management. Additional understanding of the underlying pathogenesis may help us develop novel targeted therapeutic strategies to improve rosacea.

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Prescriber Phenotypes: Variability in Topical Rosacea Treatment Patterns Among United States Dermatologists

Nicholas,

Spraul,

Fleischer

2024

JCM

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Background/Objectives: Aggregate prescribing behavior for inflammatory lesions of rosacea has been described, but individual physician behavior has not been characterized. This study aims to assess the modern state of topical rosacea drug selection by analyzing prescribing patterns among individual dermatologists. Methods: We assessed utilization patterns of four topical papulopustular rosacea agents in 2021 Medicare Part-D data. K-means cluster analysis identified prescriber phenotypes based on the proportion of claims for each drug by physician. Results: Cluster analysis identified four prescriber phenotypes for topical rosacea agents, with the majority favoring metronidazole. In each of the other clusters, metronidazole was co-prescribed alongside the primary agent. Significant predictors of phenotype included patient ages, patient risk scores, and a group practice setting. Conclusions: The study reveals nonuniform prescribing patterns for topical papulopustular rosacea treatments among U.S. dermatologists. While aggregate data indicate diverse drug utilization, cluster analysis suggests that individual prescribers tend to use a limited selection of agents.

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Emerging Medical Therapies in Rosacea: A Narrative Review

Cited by 4 publications

References 44 publications

Personalise treatment for rosacea by selecting from a range of options for individual features

Personalise treatment for rosacea by selecting from a range of options for individual features

Therapeutic strategies focusing on immune dysregulation and neuroinflammation in rosacea

Prescriber Phenotypes: Variability in Topical Rosacea Treatment Patterns Among United States Dermatologists

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