Emerging minimally invasive techniques for treating localized prostate cancer

Prostate tissue stiffness as measured with a resonance sensor system: a study on silicone and human prostate tissue in vitro

“…The resonance testing presented may have similar applications, and the ability to identify the malignant prostatic lesions which are not detectable with current imaging methods could clearly be useful in the diagnosis and staging of PCa. Furthermore, more minimally invasive management approaches to PCa are emerging [1]. The assessment of response to treatment in PCa has traditionally been through the use of PSA testing, but a modality used for the detection of PCa could also be used to assess the response to treatment and for the monitoring of prostate lesions.…”

Physical mechanisms and methods employed in drug delivery to tumors

“…The purpose of this anticancer therapy is to shrink and hopefully destroy cancer without harming noncancerous cells. It can be used to treat cancer in many areas of the body, including brain (74), thyroid (75), lungs (76), breast (77), and prostate (78). It is thought that high temperatures, up to 40°C, can help shrink cancerous tumors.…”

5α- Reductase Inhibitors in Prostate Cancer: An Overview

“…Prostatic diseases represent some of the greatest threats to men's health and the heterogeneous behavior of prostate cancer as well as multiple factors limiting patient accrual are some of the inherent challenges in the development and completion of clinical trials comparing various available therapeutic modalities ranging from active surveillance, surgical extirpation, surgical ablation, radiation therapy, hormonal therapy, to chemotherapy [7][8][9]. The specific approach used to treat PC depends upon number of factors like age, prostrate size, weight, prostate specific antigen level and stage.…”

“…As long as symptoms are mild, without histological evidence for bladder or urinary tract deterioration, watchful waiting is deemed appropriate [3]. While surgical extirpation or radiation therapy are considered for the treatment of localized prostate cancer, and hormonal therapy for locally advanced disease, biochemical recurrence after localized therapy, and metastatic disease [8].…”

“…The high prevalence and considerably lower mortality of prostate cancer, coupled with the significant potential morbidity of therapy for prostate cancer, have sparked much interest in alternative approaches against prostate cancer viz; active surveillance strategies, surgical therapies and chemotherapy [7][8][9]. Though the development and overgrowth of the prostate has been attributed to the number of the different factors like aging, late activation of cell growth by mutations in oncogenes, defective or mutated tumors suppressor gene, genetic factors and hormonal changes [3].…”