Emerging Modalities and Implantable Technologies for Neuromodulation

Won, Sang Min; Song, Enming; Reeder, Jonathan T.; Rogers, John A.

doi:10.1016/j.cell.2020.02.054

Cited by 199 publications

(159 citation statements)

References 167 publications

(251 reference statements)

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“…The basic concept of this approach may be potentially expandable for continuous monitoring of lethal cardiac diseases through chronic implantation of the device and integration with current state-of-the-art means of wirelessly communicating power and data. 39 Methods 4D heart segmentation. All ultrasound images were acquired using the Vevo 3100 small animal ultrasound system (FUJIFILM VisualSonics Inc., Toronto, Canada).…”

Section: Discussionmentioning

confidence: 99%

Rapid Custom Prototyping of Soft Poroelastic Biosensor for Simultaneous Epicardial Recording and Imaging

Kim

Soepriatna

Park

et al. 2020

Preprint

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The growing need for the implementation of stretchable biosensors in the human body and organ systems has driven a new rapid prototyping scheme through the direct ink writing (DIW) of multidimensional functional architectures in an arbitrary shape and size to meet the requirement of adapting the geometric nonlinearity of a specific biological site. Recent approaches involve the use of biocompatible viscoelastic inks that are dispensable through an automated nozzle injection system. However, their pragmatic application remains challenged in particular medical practices that demand long-term reliable recording under periodic large strain cycles, such as the cardiac cycle, due to their viscoelastic nature that produces both mechanical and electrical hysteresis. Herein, we report a new class of a poroelastic silicone composite that is adaptable for high-precision DIW of a custom-designed biosensor, which is exceptionally soft and insensitive to mechanical strain without generating significant hysteresis. The unique structural property of the composite material yields a robust and seamless coupling to living tissues, thereby enabling both high-fidelity recording of spatiotemporal electrophysiological activity and real-time ultrasound imaging for visual feedback. In vivo evaluation of a custom-fit biosensor in a murine acute myocardial infarction model demonstrates a potential clinical utility in the simultaneous intraoperative recording and imaging on the epicardial surface, which may guide a definitive surgical treatment.

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Section: Discussionmentioning

confidence: 99%

Rapid Custom Prototyping of Soft Poroelastic Biosensor for Simultaneous Epicardial Recording and Imaging

Kim

Soepriatna

Park

et al. 2020

Preprint

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“…[ 113 ] The electrodes exhibit subcellular cross‐sectional dimensions (diameter ≈7 μm) that are an order of magnitude smaller than traditional recording electrodes, resulting in a significantly reduced stiffness of 4540 N m −1 compared with other silicon probes (≈150 kN m −1 with cross‐section dimensions of 15 × 120 μm 2 ) and commercial electrodes for DBS (≈1 MN m −1 with diameters of ≈100 μm). [ 114 ] As a result, they elicit much reduced chronic tissue responses after implantation. In addition, Guitchounts et al demonstrated 16‐channel arrays built from ultrathin (diameter ≈4.5 μm) carbon fiber to record LFPs across multiple cortical regions in birds with negligible immune response.…”

Section: Materials and Devices For Electrical Biointerfacingmentioning

confidence: 99%

Advanced Electrical and Optical Microsystems for Biointerfacing

Obaid

Chen

2020

Advanced Intelligent Systems

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Electrical and optical biointerfaces have contributed considerably to understanding biological systems. Recent advances in biocompatible materials, structure designs, and fabrication techniques have established flexible and minimally invasive electronic/optoelectronic platforms that laminate onto targeted surface regions or implant into precise locations of biosystems to monitor and control various biological processes at cell, tissue, and organ levels. Herein, recent progress in advanced biointegrated electrical and optical platforms is discussed. An overview of materials and device designs to form flexible and even stretchable electrodes is presented. Strategies to reduce tissue damage and foreign‐body response to improve chronic stability are described. State‐of‐the‐art wearable and implantable microsystems with/without wireless capabilities for bioelectrical sensing and stimulation, optical recording and modulation, and multimodal operation are highlighted. In conclusion, a discussion of the remaining obstacles for future research in these areas is provided.

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“…Model-based reinforcement learning is an enhanced process whereby the computer learns from its trial-and-error experiences to build a model of experiences, adaptations, and results and then uses this model to more efficiently “choose” actions when faced with new situations. Another variation called neuromodulation allows adaptation in a BMI of the input–output sequence programmed when decoding individual neuronal signals; instead of adapting the modeled linkages between signals as with model-based reinforcement learning, the programmed response to each individual signal also changes as the machine learns through experience (Won et al 2020).…”

Section: Integration With Artificial Intelligence (Ai)mentioning

confidence: 99%

Brain–Machine Interfaces as Commodities: Exchanging Mind for Matter

Reilly

2020

Linacre Q

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Brain–machine interfaces (BMIs), which enable a two-way flow of signals, information, and directions between human neurons and computerized machines, offer spectacular opportunities for therapeutic and consumer applications, but they also present unique dangers to the safety, privacy, psychological health, and spiritual well-being of their users. The sale of these devices as commodities for profit exacerbates such issues and may subject the user to an unequal exchange with corporations. Catholic healthcare professionals and bioethicists should be especially concerned about the implications for the essential dignity of the persons using the new BMIs. Summary: The commercial sale of brain-machine interfaces (BMIs) generates and exacerbates problems for end-users' safety, psychological health, and spiritual well-being.

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Emerging Modalities and Implantable Technologies for Neuromodulation

Cited by 199 publications

References 167 publications

Rapid Custom Prototyping of Soft Poroelastic Biosensor for Simultaneous Epicardial Recording and Imaging

Rapid Custom Prototyping of Soft Poroelastic Biosensor for Simultaneous Epicardial Recording and Imaging

Advanced Electrical and Optical Microsystems for Biointerfacing

Brain–Machine Interfaces as Commodities: Exchanging Mind for Matter

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