Emerging MR Imaging and Spectroscopic Methods to Study Brain Tumor Metabolism

Kumar, Manoj; Nanga, Ravi Prakash Reddy; Verma, Gaurav; Wilson, Neil; Brisset, Jean Christophe; Nath, Kavindra; Chawla, Sanjeev

doi:10.3389/fneur.2022.789355

Cited by 14 publications

(21 citation statements)

References 110 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…[ 18 F]-Fluorodeoxyglucose (FDG) positron emission tomography (PET) is the current gold standard in clinical routine for assessing tissue-specific Glc uptake, but it requires invasive administration of unstable radioactive tracers and does not provide information on the dynamics of Glc downstream metabolites, for example, oxidative neurotransmitter synthesis of glutamate (Glu) and glutamine (Gln), or anaerobic lactate production, in, for example, tumors due to Glc trapping of [ 18 F]FDG. Therefore, a fully noninvasive approach to reliably map the brain Glc metabolism is of critical interest for clinical research and routine application 4 …”

mentioning

confidence: 99%

Noninvasive 3-Dimensional 1H-Magnetic Resonance Spectroscopic Imaging of Human Brain Glucose and Neurotransmitter Metabolism Using Deuterium Labeling at 3T

et al. 2023

View full text Add to dashboard Cite

Objectives Noninvasive, affordable, and reliable mapping of brain glucose metabolism is of critical interest for clinical research and routine application as metabolic impairment is linked to numerous pathologies, for example, cancer, dementia, and depression. A novel approach to map glucose metabolism noninvasively in the human brain has been presented recently on ultrahigh-field magnetic resonance (MR) scanners (≥7T) using indirect detection of deuterium-labeled glucose and downstream metabolites such as glutamate, glutamine, and lactate. The aim of this study was to demonstrate the feasibility to noninvasively detect deuterium-labeled downstream glucose metabolites indirectly in the human brain via 3-dimensional (3D) proton (1H) MR spectroscopic imaging on a clinical 3T MR scanner without additional hardware. Materials and Methods This prospective, institutional review board–approved study was performed in 7 healthy volunteers (mean age, 31 ± 4 years, 5 men/2 women) after obtaining written informed consent. After overnight fasting and oral deuterium-labeled glucose administration, 3D metabolic maps were acquired every ∼4 minutes with ∼0.24 mL isotropic spatial resolution using real-time motion-, shim-, and frequency-corrected echo-less 3D 1H-MR spectroscopic Imaging on a clinical routine 3T MR system. To test the interscanner reproducibility of the method, subjects were remeasured on a similar 3T MR system. Time courses were analyzed using linear regression and nonparametric statistical tests. Deuterium-labeled glucose and downstream metabolites were detected indirectly via their respective signal decrease in dynamic 1H MR spectra due to exchange of labeled and unlabeled molecules. Results Sixty-five minutes after deuterium-labeled glucose administration, glutamate + glutamine (Glx) signal intensities decreased in gray/white matter (GM/WM) by −1.63 ± 0.3/−1.0 ± 0.3 mM (−13% ± 3%, P = 0.02/−11% ± 3%, P = 0.02), respectively. A moderate to strong negative correlation between Glx and time was observed in GM/WM (r = −0.64, P < 0.001/r = −0.54, P < 0.001), with 60% ± 18% (P = 0.02) steeper slopes in GM versus WM, indicating faster metabolic activity. Other nonlabeled metabolites showed no significant changes. Excellent intrasubject repeatability was observed across scanners for static results at the beginning of the measurement (coefficient of variation 4% ± 4%), whereas differences were observed in individual Glx dynamics, presumably owing to physiological variation of glucose metabolism. Conclusion Our approach translates deuterium metabolic imaging to widely available clinical routine MR scanners without specialized hardware, offering a safe, affordable, and versatile (other substances than glucose can be labeled) approach for noninvasive imaging of glucose and neurotransmitter metabolism in the human brain.

show abstract

mentioning

confidence: 99%

Noninvasive 3-Dimensional 1H-Magnetic Resonance Spectroscopic Imaging of Human Brain Glucose and Neurotransmitter Metabolism Using Deuterium Labeling at 3T

et al. 2023

View full text Add to dashboard Cite

show abstract

“…This method can be presented as a single radiofrequency pulse p 1 with a specific evolutionary time t 1 that is followed by a second pulse p 2 and by a measurement time t 2 . 50 A result of the COSY experiment is a two-dimensional spectrum that plots the frequency of a single isotope (mostly 1 H) along two axes. It should be noted that nowadays this method with some modifications allows obtaining a 2D spectrum with frequencies of different isotopes ( 13 C and 1 H).…”

Section: Basis Of Nmr Analysismentioning

confidence: 99%

Advances in nuclear magnetic resonance spectroscopy: case of proton conductive materials

et al. 2023

View full text Add to dashboard Cite

show abstract

“…The commonest available MRS modality is the proton [1H; hydrogen] spectroscopy [4] . is a wide list of metabolites that may be useful in the MRS evaluation of brain lesions including: NNA [N-acetyl-aspartate], choline, creatine, lipids, lactate, alanine and myo-inositol [5] . MRS helps to afford more clinically relevant data for several neurological diseases of pediatrics [e.g., brain neoplasms, infectious conditions and white matter disorders] [6] .…”

Section: Introductionmentioning

confidence: 99%

Magnetic Resonance Spectroscopy Role in Assessment of Pediatric Supratentorial Brain Lesions

Elgamal

El-Wahab

Shakweer

2022

International Journal of Medical Arts

View full text Add to dashboard Cite

Article informationBackground: Magnetic resonance spectroscopy [MRS] is of value for pediatric neurologist, as it confers relevant information from the clinical point of view. It is worth for brain tumors, infections and disorders of the white matter. MRS metabolites add additional value to the therapeutic solutions when MRS combined with other high-resolution imaging modalities. Objective:The current work aimed to assess the role of magnetic resonance spectroscopy in pediatric supratentorial brain lesions. Patients and methods: This study recruited a convenient sample of thirty patients [21 females and 9 males]. Their age ranged between one and sixteen years. All were submitted to single-voxel H-MR spectroscopy with the same MR unit using point resolved spectroscopy [PRESS] sequence, using short TE [35] and long TE [144] spectra. Then spectrum analysis was performed to obtain the important ratios: choline/Nacetylaspartate, choline/creatine and mI/Cr to reach the diagnosis of the supratentorial lesion. Result: The choline/N-acetylaspartate [Cho/NAA], choline/creatine [Cho/Cr] and mI/Cr ratios were statistically difference between neoplastic and non-neoplastic lesions at cutoffs 2, 1.6, & 1.15 respectively. The peak of lipid lactate was only present and significant for differentiating high-from low-grade tumors. Conclusion: MRS is valuable in differential diagnosis of brain lesions, as it differentiates neoplastic from non-neoplastic tumors. It also plays a complementary role with magnetic resonance imaging [MRI] in the follow up of therapeutic response.

show abstract

Emerging MR Imaging and Spectroscopic Methods to Study Brain Tumor Metabolism

Cited by 14 publications

References 110 publications

Noninvasive 3-Dimensional 1H-Magnetic Resonance Spectroscopic Imaging of Human Brain Glucose and Neurotransmitter Metabolism Using Deuterium Labeling at 3T

Noninvasive 3-Dimensional 1H-Magnetic Resonance Spectroscopic Imaging of Human Brain Glucose and Neurotransmitter Metabolism Using Deuterium Labeling at 3T

Advances in nuclear magnetic resonance spectroscopy: case of proton conductive materials

Magnetic Resonance Spectroscopy Role in Assessment of Pediatric Supratentorial Brain Lesions

Contact Info

Product

Resources

About