Emerging Nanotechnology in Non-Surgical Periodontal Therapy in Animal Models: A Systematic Review

Brun, Adrian; Moignot, Nicolas; Colombier, Marie‐Laure; Dursun, Elisabeth

doi:10.3390/nano10071414

Cited by 8 publications

(8 citation statements)

References 47 publications

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“…Nanodentistry deals mainly with nanobiomaterials applied to dentistry and is a growing field of research with high potential for clinical translation [4,5,[13][14][15][16][17][18][19]. It is a term also employed when characterization techniques in the nanoscale regime are employed for dental materials and tissues.…”

Section: Nanodentistrymentioning

confidence: 99%

Exploiting Nanomaterials for Optical Coherence Tomography and Photoacoustic Imaging in Nanodentistry

et al. 2022

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There is already a societal awareness of the growing impact of nanoscience and nanotechnology, with nanomaterials (with at least one dimension less than 100 nm) now incorporated in items as diverse as mobile phones, clothes or dentifrices. In the healthcare area, nanoparticles of biocompatible materials have already been used for cancer treatment or bioimaging enhancement. Nanotechnology in dentistry, or nanodentistry, has already found some developments in dental nanomaterials for caries management, restorative dentistry and orthodontic adhesives. In this review, we present state-of-the-art scientific development in nanodentistry with an emphasis on two imaging techniques exploiting nanomaterials: optical coherence tomography (OCT) and photoacoustic imaging (PAI). Examples will be given using OCT with nanomaterials to enhance the acquired imaging, acting as optical clearing agents for OCT. A novel application of gold nanoparticles and nanorods for imaging enhancement of incipient occlusal caries using OCT will be described. Additionally, we will highlight how the OCT technique can be properly managed to provide imaging with spatial resolution down to 10′s–100′s nm resolution. For PAI, we will describe how new nanoparticles, namely TiN, prepared by femtosecond laser ablation, can be used in nanodentistry and will show photoacoustic microscopy and tomography images for such exogenous agents.

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Section: Nanodentistrymentioning

confidence: 99%

Exploiting Nanomaterials for Optical Coherence Tomography and Photoacoustic Imaging in Nanodentistry

et al. 2022

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“…• the combination of different types of active ingredients and the incorporation of innovative molecules: given the dual infectious and inflammatory nature of periodontitis, the combined use of antimicrobials and agents that modulate inflammation or growth factors should be further explored in order to propose even more effective systems as for example, the combination of chlorhexidine and ibuprofen (figure 8) [122]. In the recent years nanotechnologies have attracted much attention in medicine and dentistry [125]. Nanoparticles can be used as carriers for a large range of molecules and provide an accurate delivery to targeted sites non-accessible to other systems including deep periodontal pockets [126].…”

Section: Current Issues and Future Prospects For Isfi In Periodontal ...mentioning

confidence: 99%

“…The combination of nanoparticles and in-situ forming systems has also been proposed to benefit from the advantages of each system [127]. Despite of these promising perspectives safety concerns remain to be clarified for the use of nanoparticles in periodontal therapy [125]. • Broadening the scope of applications: ISFI are versatile vectors that could be of interest for the release of active pharmaceutical ingredients for the treatment or prevention of other oral diseases, for example the release of fluoride for caries, antioxidants to prevent the effects of oxidative stress or anti-inflammatory agents in chronic lesions of the oral mucosa.…”

Section: Current Issues and Future Prospects For Isfi In Periodontal ...mentioning

confidence: 99%

In-situ forming drug-delivery systems for periodontal treatment: current knowledge and perspectives

Dubar¹,

Lizambard²,

Delcourt-Debruyne³

et al. 2021

Biomed. Mater.

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Several chemical compounds are considered to be promising as adjuvants in the treatment of periodontitis. Antimicrobials, anti-inflammatory drugs or, more recently, pro-regenerative or antioxidant molecules have shown a very interesting potential to improve the outcomes of mechanical biofilm removal and promote the healing of the damaged tissues. However, their clinical effect is often limited by the challenge of achieving effective and prolonged drug delivery within the periodontal lesion, while limiting the risk of toxicity. In-situ forming implants (ISFI) are ‘implantable’ drug-delivery systems that have gained considerable attention over the last few decades due to their multiple biomedical applications. They are liquids that, when injected at the site to be treated, form a semi-solid or solid dosage form that provides safe and locally controlled drug release. This review discusses current data and future prospects for the use of ISFI in periodontal treatment.

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“…Various biodegradable nanocarrier strategies have been investigated for the treatment of periodontitis, including polylactic- co -glycolic acid (PLGA), chitosan, and silica-derived nanoparticles [ 23 , 24 , 25 ]. According to Brun and colleagues [ 26 ]. The agents modulating inflammation in periodontitis seem to be relevant in terms of efficiency.…”

Section: Introductionmentioning

confidence: 99%

Effect of Dexamethasone-Loaded PLGA Nanoparticles on Oral Mucositis Induced by 5-Fluorouracil

et al. 2021

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Oral mucositis (OM) is characterized by the presence of severe ulcers in the oral region that affects patients treated with chemotherapy. It occurs in almost all patients who receive radiotherapy of the head and neck, as well as patients who undergo hematopoietic cell transplantation. The pathophysiology of OM is complex, and there is no effective therapy. The aim of this study was to evaluate the effect of dexamethasone-loaded poly(d,l-Lactic-co-glycolic) nanoparticles (PLGA-DEX NPs) on an OM model induced in hamsters. The NPs were synthesized using the emulsification-solvent evaporation method and were characterized by the size, zeta potential, encapsulation efficiency, atomic force microscopy, physicochemical stability, and the in vitro release. The OM was induced by the administration of 5-FU on the first and second days and mechanical trauma on the 4th day of the experiment. PLGA-DEX NPs were administered to treat OM. The animals were euthanized on the 10th day. Macroscopic and histopathological analyses were performed, measurement of malonaldehyde (MDA) and ELISA was used to determine the levels of IL-1β and TNF-α. Immunoexpressions of NF-κB, COX-2, and TGF-β were determined by immunohistochemistry, and qRT-PCR was used to quantify the gene expression of the GILZ, MKP1, and NF-κB p65. The PLGA-DEX NPs (0.1 mg/kg) significantly reduced macroscopic and histopathological scores, decreased MDA, TNF-α and IL-1β levels, immunostaining for NF-κB, COX-2, TGF-β, and suppressed NF-κB p65 mRNA expression, but increased GILZ and MKP1 expression.

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Emerging Nanotechnology in Non-Surgical Periodontal Therapy in Animal Models: A Systematic Review

Cited by 8 publications

References 47 publications

Exploiting Nanomaterials for Optical Coherence Tomography and Photoacoustic Imaging in Nanodentistry

Exploiting Nanomaterials for Optical Coherence Tomography and Photoacoustic Imaging in Nanodentistry

In-situ forming drug-delivery systems for periodontal treatment: current knowledge and perspectives

Effect of Dexamethasone-Loaded PLGA Nanoparticles on Oral Mucositis Induced by 5-Fluorouracil

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