Emerging nanotherapeutic strategies targeting gut-X axis against diseases

Sun, Ao; Liu, Hongyu; Sun, Mengchi; Yang, Weiguang; Liu, Jiaxin; Lin, Yi; Shi, Xianbao; Sun, Jin; Liu, Linlin

doi:10.1016/j.biopha.2023.115577

Biomedicine & Pharmacotherapy

2023

DOI: 10.1016/j.biopha.2023.115577

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Emerging nanotherapeutic strategies targeting gut-X axis against diseases

Ao Sun,

Hongyu Liu,

Mengchi Sun

et al.

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2024

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Cited by 2 publications

References 179 publications

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Modulatory effects of traditional Chinese medicines on gut microbiota and the microbiota-gut-x axis

Luo,

Che,

Guo

et al. 2024

Front. Pharmacol.

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The gut microbiota offers numerous benefits to the human body, including the promotion of nutrient absorption, participation in metabolic processes, and enhancement of immune function. Recent studies have introduced the concept of the gut-organ axis, which encompasses interactions such as the gut-brain axis, gut-liver axis, and gut-lung axis. This concept underscores the complex interplay between gut microbiota and various organs and tissues, including the brain, heart, lungs, liver, kidneys, muscles, and bones. Growing evidence indicates that gut microbiota can influence the onset and progression of multi-organ system diseases through their effects on the gut-organ axis. Traditional Chinese medicine has demonstrated significant efficacy in regulating the gastrointestinal system, leveraging its unique advantages. Considerable advancements have been made in understanding the role of gut microbiota and the gut-organ axis within the mechanisms of action of traditional Chinese medicine. This review aims to elucidate the roles of gut microbiota and the gut-organ axis in human health, explore the potential connections between traditional Chinese medicine and gut microbiota, and examine the therapeutic effects of traditional Chinese medicine on the microbiota-gut-organ axis. Furthermore, the review addresses the limitations and challenges present in current research while proposing potential directions for future investigations in this area.

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Modulatory effects of traditional Chinese medicines on gut microbiota and the microbiota-gut-x axis

Luo,

Che,

Guo

et al. 2024

Front. Pharmacol.

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Climbing the longevity pyramid: overview of evidence-driven healthcare prevention strategies for human longevity

Martinović,

Mantovani,

Trpchevska

et al. 2024

Front. Aging

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Longevity medicine is an emerging and iterative healthcare discipline focusing on early detection, preventive measures, and personalized approaches that aim to extend healthy lifespan and promote healthy aging. This comprehensive review introduces the innovative concept of the “Longevity Pyramid.” This conceptual framework delineates progressive intervention levels, providing a structured approach to understanding the diverse strategies available in longevity medicine. At the base of the Longevity Pyramid lies the level of prevention, emphasizing early detection strategies and advanced diagnostics or timely identification of potential health issues. Moving upwards, the next step involves lifestyle modifications, health-promoting behaviors, and proactive measures to delay the onset of age-related conditions. The Longevity Pyramid further explores the vast range of personalized interventions, highlighting the importance of tailoring medical approaches based on genetic predispositions, lifestyle factors, and unique health profiles, thereby optimizing interventions for maximal efficacy. These interventions aim to extend lifespan and reduce the impact and severity of age-related conditions, ensuring that additional years are characterized by vitality and wellbeing. By outlining these progressive levels of intervention, this review offers valuable insights into the evolving field of longevity medicine. This structured framework guides researchers and practitioners toward a nuanced strategic approach to advancing the science and practice of healthy aging.

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Emerging nanotherapeutic strategies targeting gut-X axis against diseases

Cited by 2 publications

References 179 publications

Modulatory effects of traditional Chinese medicines on gut microbiota and the microbiota-gut-x axis

Modulatory effects of traditional Chinese medicines on gut microbiota and the microbiota-gut-x axis

Climbing the longevity pyramid: overview of evidence-driven healthcare prevention strategies for human longevity

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