Emerging non-cancer applications of therapeutic ultrasound

Abstract

Ultrasound therapy has been investigated for over half a century. Ultrasound can act on tissue through a variety of mechanisms, including thermal, shockwave and cavitation mechanisms, and through these can elicit different responses. Ultrasound therapy can provide a non-invasive or minimally invasive treatment option, and ultrasound technology has advanced to the point where devices can be developed to investigate a wide range of applications. This review focuses on non-cancer, clinical applications of therapeutic ultrasound, with an emphasis on treatments that have recently reached clinical investigations, and preclinical research programs that have great potential to impact patient care.

Synergistic Efficacy of Ultrasound, Sonosensitizers and Chemotherapy: A Review

“…The oscillations result in the streaming of surrounding fluid thereby inducing future science group Synergistic efficacy of ultrasound, sonosensitizers & chemotherapy Review mechanical stresses. Although stable cavitation can cause various bioeffects, permanent tissue damage is typically not observed [15]. Higher pressure amplitudes may result in violent bubble collapse accompanied by shock waves with high pressures and shear forces that can cause significant mechanical damage to tissues: a phenomenon known as inertial cavitation.…”

Evaluation of the effect of ultrasonic heating and exercise heating on muscles by ultrasound elastography: An experimental clinical trial

“…Ultrasound can be applied in water for uneven surface areas such as hands, feet, elbows. One session takes 5-15 minutes once a day or every other day [6,7].…”

Ultrasound: The versatile energy source

“…This can lead to subtle changes, or to tissue tearing and obvious mechanical damage. Many of the therapeutic techniques currently under pre-clinical investigation involve the introduction of microbubbles with the aim of using their interaction with ultrasound at the intravascular lumen to cause a temporary opening of the blood-brain barrier, or other vessels, in order to enhance drug delivery [6][7][8][9]. It has also been suggested, for example, that inertial cavitation is needed before the adenovirus uptake can be enhanced in vivo [10].…”