Emerging Novel Pharmacological Non-opioid Therapies in Headache Management: a Comprehensive Review

Kaye, Alan D.; Motejunas, Mark W.; Cornett, Elyse M.; Ehrhardt, Ken P.; Novitch, Matthew B.; Class, Joshua; Siddaiah, Harish; Hart, Brendon M.; Urman, Richard D.

doi:10.1007/s11916-019-0808-7

Cited by 6 publications

(9 citation statements)

References 45 publications

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“…The goal of the therapy being a significant reduction in pain to restore daily functional capacity with while minimizing opioid use. 8 SPGB can be performed through transnasal, transoral, or infrazygomatic approaches. The transnasal approach has a risk of epistaxis and infection but is the simplest technique.…”

Section: Discussionmentioning

confidence: 99%

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Sphenopalatine Ganglion Block for Postdural Puncture Headaches in a Thrombocytopenic Adolescent Young Adult: A Case Report

Lo¹,

Shi²,

Kim³

2021

Journal of Pediatric Hematology/Oncology

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The epidural blood patch is the gold-standard therapy to treat postdural puncture headaches from dural puncture when conservative therapies fail. However, an epidural blood patch is contraindicated in patients with coagulopathy and thrombocytopenia (platelet count of 60,000/µL) due to concerns of an epidural hematoma. We present a case of an adolescent with acute lymphocytic leukemia, thrombocytopenia, and persistent postdural puncture headaches. The patient was successfully treated with a sphenopalatine ganglion nerve block at the bedside without any side effects and complications.

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Section: Discussionmentioning

confidence: 99%

“…It is utilized to treat a variety of headache and facial pain syndromes such as cluster headache, migraine headache, and trigeminal neuralgia with variable efficacy. The goal of the therapy being a significant reduction in pain to restore daily functional capacity with while minimizing opioid use 8…”

Section: Discussionmentioning

confidence: 99%

Sphenopalatine Ganglion Block for Postdural Puncture Headaches in a Thrombocytopenic Adolescent Young Adult: A Case Report

Lo¹,

Shi²,

Kim³

2021

Journal of Pediatric Hematology/Oncology

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“…When conventional headache treatments fail to provide relief, interventional techniques may be used. One such treatment includes occipital nerve stimulation (2). Treatment of headaches by ONS was first introduced by Weiner and Reed in 1999.…”

Section: Discussionmentioning

confidence: 99%

“…Typically, headaches cause a range of symptoms in the head and neck region and are often treated with opioids. Patients with chronic headache do not always gain relief from such treatment, therefore, interventional techniques such as ONS may be considered (2). The central nervous system is susceptible to neurotoxicity from many types of chemotherapeutic agents (3).…”

Section: To the Editormentioning

confidence: 99%

Successful Treatment of Chemotherapy-Induced Headaches With Occipital Nerve Stimulation: A Case Report

Abd‐Elsayed

Pahapill

2020

Neuromodulation: Technology at the Neural Interface

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“…To minimize patients' exposure to the risks of opioid use, physicians have established and implemented the use of multimodal analgesics. A multimodal regimen refers to the use of two or more medications from different classes to achieve pain relief [9]. This technique may reduce patients' reliance on opioids, thereby decreasing the onset of opioid-induced adverse drug events.…”

Section: Introductionmentioning

confidence: 99%

A Systematic Review of Non-Opioid Pain Management in Chiari Malformation (Type 1) Patients: Current Evidence and Novel Therapeutic Opportunities

Barpujari

Kiley

Ross

et al. 2023

JCM

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Chiari Malformation Type I (CM) includes a range of cranial abnormalities at the junction of the skull with the spine, with common symptoms including pain and headaches. Currently, CM pain is managed medically through anti-inflammatory drugs, muscle relaxants, and opioids, while surgical management includes posterior fossa decompression. Given the adverse effects of opioid use, and an ongoing opioid epidemic, there is a need for safe, non-opioid alternatives for clinical pain management. This systematic review was performed to provide an update on the current literature pertaining to the treatment of CM pain with non-opioid alternatives. A literature search was performed in June 2022 utilizing the PubMed and Google Scholar databases, and articles were identified that included information regarding non-opioid pain management in CM patients. A total of 90 articles were obtained from this search, including 10 relevant, drug-specific studies. Two independent reviewers selected and included all relevant articles based on the chosen search criteria to minimize bias risk. Currently available treatments for neurosurgical pain management include anticonvulsants, corticosteroids, NSAIDs, anti-inflammatory drugs, NMDA receptor antagonists, local anesthetics, nerve blocks, scalp blocks, and neuromuscular blocks. While more information is needed on the use of non-opioid pain management, the present literature provides potential evidence of its efficacy amongst the CM patient population, on account of the success that non-opioid pain management has demonstrated within other neurological pain syndromes. Further research into non-pharmacological pain management would also benefit the CM population and could be generalized to related conditions.

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Emerging Novel Pharmacological Non-opioid Therapies in Headache Management: a Comprehensive Review

Cited by 6 publications

References 45 publications

Sphenopalatine Ganglion Block for Postdural Puncture Headaches in a Thrombocytopenic Adolescent Young Adult: A Case Report

Sphenopalatine Ganglion Block for Postdural Puncture Headaches in a Thrombocytopenic Adolescent Young Adult: A Case Report

Successful Treatment of Chemotherapy-Induced Headaches With Occipital Nerve Stimulation: A Case Report

A Systematic Review of Non-Opioid Pain Management in Chiari Malformation (Type 1) Patients: Current Evidence and Novel Therapeutic Opportunities

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