Emerging Pathophysiological Targets of Psoriasis for Future Therapeutic Strategies

Yadav, Monu; Sardana, Ishu; Sharma, Anupama; Sharma, Nidhi; Nagpal, Kalpana; Malik, Paramjeet

doi:10.2174/1871526519666190617162701

Cited by 4 publications

(1 citation statement)

References 84 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The major biological pathways of psoriasis were deduced by a literature survey (Rácz and Prens, 2009 ; Bejarano and Valdecantos, 2013 ; Baliwag et al, 2015 ; Hugh and Weinberg, 2018 ; Yadav et al, 2019 ), and this revealed that Tumor necrosis factor-α (TNF-α), interleukin-1α (IL-1α), IL-1β, IL-13, IL-12/23, IL-17, IL-22, IL-36γ, Interferon-γ (IFN-γ), Nuclear Factor-κB (NF-κB), endothelial nitric oxide synthase (eNOS), inducible NOS (iNOS), Peroxisome proliferator-activated receptor gamma (PPAR-γ), MAP Kinase-Activated Protein Kinase 2 (MAPK2), Janus Kinase 1 (JAK1), JAK2, JAK3, and the Signal transducer and activator of transcription 3 (STAT3) play important roles in the pathogenesis of psoriasis. Moreover, the druggable macromolecules were also confirmed by Kyoto Encyclopedia of Genes and Genomes (KEGG) database ( https://www.kegg.jp/ ), which showed that the NF-κB, IL-17, and IL-36 pathways are particularly involved in psoriasis (KEGG ID: H01656).…”

Section: Methodsmentioning

confidence: 99%

Diterpenoids and Triterpenoids From Frankincense Are Excellent Anti-psoriatic Agents: An in silico Approach

et al. 2020

View full text Add to dashboard Cite

Psoriasis is a chronic autoimmune disease that affects 2–3% of the global population and requires an effective treatment. Frankincense has been long known for its potent anti-inflammatory activities. In this study, a structural bioinformatics approach was used to evaluate the efficacy of individual active components of frankincense, macrocyclic diterpenoid derivatives ( 1 - 27 ), and boswellic acids ( 28 - 46 ) in the treatment of psoriasis. Initially, major druggable targets of psoriasis were identified. Subsequently, structure-based screening was employed by using three different docking algorithms and scoring functions (MOE, AutoDock Vina, and MVD) for the target fishing of compounds against 18 possible targets of psoriasis. Janus Kinase 1, 2, 3 (JAK 1/2/3), eNOS, iNOS, interleukin-17 (IL-17), and Tumor necrosis factor-α (TNF-α) were identified as the preferred molecular targets for these compounds. This computational analysis reflects that frankincense diterpenoids and triterpenoids can serve as excellent anti-psoriatic agents by targeting major cytokines (TNF-α, IL-17, IL-13, IL-23, and IL-36γ,) exacerbated in psoriasis, and inflammatory pathways particularly JAK1/2/3, eNOS, iNOS, MAPK2, and IFNγ. The results were compared with the reported experimental findings which correlates well with our in-silico verdicts.

show abstract

Section: Methodsmentioning

confidence: 99%

Diterpenoids and Triterpenoids From Frankincense Are Excellent Anti-psoriatic Agents: An in silico Approach

et al. 2020

View full text Add to dashboard Cite

show abstract

Targeting keratinocyte hyperproliferation, inflammation, oxidative species and microbial infection by biological macromolecule-based chitosan nanoparticle-mediated gallic acid–rutin combination for the treatment of psoriasis

et al. 2019

View full text Add to dashboard Cite

Identification of psoriasis‐associated immune marker G3BP2 through single‐cell RNA sequencing and meta analysis

Gao,

Fan,

Wang

et al. 2024

Immunology

View full text Add to dashboard Cite

Psoriasis is a chronic skin disease with an increasing prevalence each year. However, the mechanisms underlying its onset and progression remain unclear, and effective therapeutic targets are lacking. Therefore, we employs an innovative approach by combining single‐cell RNA sequencing (scRNA‐seq) with meta‐analysis. This not only elucidates the potential mechanisms of psoriasis at the cellular level but also identifies immunoregulatory marker genes that play a statistically significant role in driving psoriasis progression through comprehensive analysis of multiple datasets. Skin tissue samples from 12 psoriasis patients underwent scRNA‐seq, followed by quality control, filtering, PCA dimensionality reduction, and tSNE clustering analysis to identify T cell subtypes and differentially expressed genes (DEGs) in psoriatic skin tissue. Next, three psoriasis datasets were standardised and merged to identify differentially expressed genes (DEGs). Subsequently, weighted gene co‐expression network analysis (WGCNA) was applied for clustering analysis of gene co‐expression network modules and to assess the correlation between these modules and DEGs. Least absolute shrinkage and selection operator (LASSO) regression and receiver operating characteristic (ROC) curve analyses were conducted to select disease‐specific genes and evaluate their diagnostic value. Single‐cell data revealed nine cell types in psoriatic skin tissue, with seven T cell subtypes identified. Intersection analysis identified ADAM8 and G3BP2 as key genes. Through the integration of scRNA‐seq and Meta analysis, we identified the immunoregulatory marker gene G3BP2, which is associated with the onset and progression of psoriasis and holds clinical significance. G3BP2 is speculated to promote the development of psoriasis by increasing the proportion of CD8+ T cells.

show abstract

Emerging Pathophysiological Targets of Psoriasis for Future Therapeutic Strategies

Cited by 4 publications

References 84 publications

Diterpenoids and Triterpenoids From Frankincense Are Excellent Anti-psoriatic Agents: An in silico Approach

Diterpenoids and Triterpenoids From Frankincense Are Excellent Anti-psoriatic Agents: An in silico Approach

Targeting keratinocyte hyperproliferation, inflammation, oxidative species and microbial infection by biological macromolecule-based chitosan nanoparticle-mediated gallic acid–rutin combination for the treatment of psoriasis

Identification of psoriasis‐associated immune marker G3BP2 through single‐cell RNA sequencing and meta analysis

Contact Info

Product

Resources

About