Emerging Pharmacologic Treatments for Adolescent Substance Use: Challenges and New Directions

Miranda, Robert; Treloar, Hayley

doi:10.1007/s40429-016-0098-7

Cited by 13 publications

(5 citation statements)

References 101 publications

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“…Specifically, we examined the sequenced relationship between craving and heavy drinking. This approach is well suited to test intervention effects on substance use and, perhaps more uniquely, to evaluate which treatment- induced changes (i.e., mechanisms) account for intervention effects and under what conditions (Miranda & Treloar, 2016).…”

Section: Introductionmentioning

confidence: 99%

Real-time assessment of alcohol craving and naltrexone treatment responsiveness in a randomized clinical trial

Miranda

Padovano

Gray

et al. 2018

Addictive Behaviors

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Findings provide the first in vivo evidence that, among carriers of the DRD4-L allele, naltrexone blunts craving in real-world settings, and this effect in turn reduces the likelihood of heavy drinking. This work highlights the utility of EMA methods for elucidating how treatments work and further demonstrates the importance of genetic factors for understanding individual differences in pharmacotherapy responsiveness.

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Section: Introductionmentioning

confidence: 99%

Real-time assessment of alcohol craving and naltrexone treatment responsiveness in a randomized clinical trial

Miranda

Padovano

Gray

et al. 2018

Addictive Behaviors

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“…One potential approach to enhancing treatment outcome is to consider the use of adjunctive medications. There is limited research on MAUD in this population 68 . However, there is preliminary evidence for the tolerability, safety, and efficacy of naltrexone in adolescents with AUD 69,70 .…”

Section: Treatment Of Aud In Special Populationsmentioning

confidence: 99%

“…There is limited research on MAUD in this population. 68 However, there is preliminary evidence for the tolerability, safety, and efficacy of naltrexone in adolescents with AUD. 69,70 The results of these studies suggest that MAUD in adolescents could help improve treatment effectiveness.…”

Section: Adolescents and Young Adultsmentioning

confidence: 99%

Medication treatment for alcohol use disorder in special populations

et al. 2023

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Background and ObjectivesAlcohol use disorder (AUD) is a significant public health concern, with underutilized effective treatments, particularly in special populations. This article summarizes the current evidence and guidelines for treating AUD in special populations.MethodsThis article is a literature review that synthesizes the latest research on AUD treatment for special populations. We screened 242 articles and included 57 in our final review.ResultsThere are four food and Drug Administration‐approved medications for AUD (MAUD): disulfiram, oral naltrexone, extended‐release injectable naltrexone (XR‐NTX), and acamprosate. Naltrexone and disulfiram have the potential to cause liver toxicity, and acamprosate should be avoided in patients with severe kidney disease. Psychosocial treatments should be considered first‐line for pregnant and nursing patients. Naltrexone is contraindicated in patients on opioids, as it may precipitate acute withdrawal. For patients experiencing homelessness, nonabstinent treatment goals may be more practical, and XR‐NTX should be considered to improve adherence. Limited evidence suggests medication can improve AUD treatment outcomes in adolescents and young adults. For patients with poor treatment response despite adequate medication adherence, switching to a different medication and augmentation with psychosocial treatments should be considered.Discussion and ConclusionsUnderstanding the unique considerations for special populations with AUD is crucial, and addressing their special needs may improve their treatment outcomes.Scientific SignificanceOur study significantly contributes to the existing literature by summarizing crucial information for the treatment of AUD in special populations, highlighting distinct challenges, and emphasizing tailored approaches to improve overall health and well‐being.

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Section: Introductionmentioning

confidence: 99%

“…Ecological momentary assessment (EMA) methods use repeated assessments to capture participants' emotional, behavioral, or cognitive experiences via mobile electronic devices, in real time, while participants are in their natural environment (Shiffman, 2009; Stone & Shiffman, 1994). This form of data collection allows researchers to understand momentary effects of acute alcohol intoxication while in the natural environment (Miranda & Treloar, 2016). Ecological momentary assessment also enhances the generalizability of findings by reducing recall bias that can affect more traditional global or single occasion measures that rely exclusively on retrospective reporting.…”

Section: Introductionmentioning

confidence: 99%

Effects of social drinking context on subjective effects, affect, and next‐day appraisals in the natural environment

Acuff,

Padovano,

Carpenter

et al. 2024

Alcohol, Clinical and Experimental Research

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BackgroundDrinking commonly occurs in social settings and may bolster social reinforcement. Laboratory studies suggest that subjective effects and mood are mechanisms through which the social context influences alcohol consumption. Ecological momentary assessment (EMA) may be useful for extending these findings to the natural environment. This pre‐registered secondary analysis of EMA data investigated the influence of the social environment on: (1) stimulating and sedating subjective effects of alcohol, (2) contentedness and negative affect, and (3) next‐day evaluations of the drinking occasion.MethodsNontreatment seeking adults reporting past‐month heavy drinking (N = 131; Mage = 28.09; 42% female) completed 7 days of EMA (in the morning, at random, and following drinking prompts), which included questions on their social context (drinking in the presence of known others or alone), contemporaneous stimulating and sedating effects, contentedness and negative affect, alcohol consumption, and next‐day evaluations of a prior day's drinking event (how satisfying/pleasant was drinking). We used multi‐level models in SAS 9.4 M7 software to examine relations among the variables.ResultsContemporaneous subjective effects (stimulating or sedating), negative affect, and contentedness did not significantly depend on the social context. For next‐day evaluations of pleasure/satisfaction from drinking, context effects were dependent on consumption totals. As the total number of standard drinks consumed increased, recollections of pleasure/satisfaction were higher when drinking had occurred with others, relative to alone. At lower consumption totals, next‐day evaluations did not appear to depend on social context.ConclusionsWhen reported contemporaneously, subjective effects and affect do not appear dependent upon the presence of known others. However, heavier drinking events, relative to lighter drinking events, are appraised more favorably the following day when occurring within social contexts.

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Emerging Pharmacologic Treatments for Adolescent Substance Use: Challenges and New Directions

Cited by 13 publications

References 101 publications

Real-time assessment of alcohol craving and naltrexone treatment responsiveness in a randomized clinical trial

Real-time assessment of alcohol craving and naltrexone treatment responsiveness in a randomized clinical trial

Medication treatment for alcohol use disorder in special populations

Effects of social drinking context on subjective effects, affect, and next‐day appraisals in the natural environment

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