Emerging Phospholipid Nanobiomaterials for Biomedical Applications to Lab-on-a-Chip, Drug Delivery, and Cellular Engineering

Abstract

The design of advanced nanobiomaterials to improve analytical accuracy and therapeutic efficacy has become an important prerequisite for the development of innovative nanomedicines. Recently, phospholipid nanobiomaterials including 2-methacryloyloxyethyl phosphorylcholine (MPC) have attracted great attention with remarkable characteristics such as resistance to nonspecific protein adsorption and cell adhesion for various biomedical applications. Despite many recent reports, there is a lack of comprehensive review on the phospholipid nanobiomaterials from synthesis to diagnostic and therapeutic applications. Here, we review the synthesis and characterization of phospholipid nanobiomaterials focusing on MPC polymers and highlight their attractive potentials for applications in micro/nanofabricated fluidic devices, biosensors, lab-on-a-chip, drug delivery systems (DDSs), COVID-19 potential usages for early diagnosis and even treatment, and artificial extracellular matrix scaffolds for cellular engineering.

Folic Acid-Adorned Curcumin-Loaded Iron Oxide Nanoparticles for Cervical Cancer

“…However, cervical cancer is still a leading cause of death among women and new therapeutic strategies should be designed for its treatment . Nanotechnological approaches including the use of microfluidic devices, high-gravity techniques, microporous smart nanostructures, green methodologies, and combinations would be a great help in order to improve the efficiency, reduce the cost of methods, increase the greenness factors, and also reduce the time of drug/method discovery. − …”

Detection of Dopamine Receptors Using Nanoscale Dendrimer for Potential Application in Targeted Delivery and Whole-Body Imaging: Synthesis and In Vivo Organ Distribution

“…The results of TEM analysis revealed that dopamine–dendrimer has a quasi-spherical structure (Figure C). However, while the TEM results are the most reliable data regarding the nanoscale morphology and size, − the images suffered from low solubility and dispersibility of the nanoparticles. − The examination of the size distribution of this image indicates that the particle size is in the range of 15–50 nm at about 35.917 ± 0.76 nm (Figure D). In agreement with other studies, there is a difference between TEM sizes and DLS measurements that are normally attributed to the fundamental difference between intensity- and number-weighted particle size distributions and the differences between the dry and hydrodynamic radii of particles.…”

Electrically conductive carbon‐based (bio)‐nanomaterials for cardiac tissue engineering

“…Different biomaterials and their combinations are currently under investigation for tissue engineering. 42 Decellularized tissues have been widely used as either cell seeding or cell‐free substrates. 27 Extracellular matrix‐derived materials are beneficial since they provide a native microenvironment for the specific cells to survive, proliferate, and differentiate.…”

“…Different biomaterials and their combinations are currently under investigation for tissue engineering 42 . Decellularized tissues have been widely used as either cell seeding or cell‐free substrates 27 .…”