Emerging proteomics biomarkers and prostate cancer burden in Africa

Adeola, Henry Ademola; Blackburn, Jonathan M.; Rebbeck, Timothy R.; Zerbini, Luiz F.

doi:10.18632/oncotarget.16568

Cited by 23 publications

(20 citation statements)

References 123 publications

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“…Nevertheless, the exact mechanism of biomarkers in carcinogenesis is still unclear [ 10 ]. Therefore, more and more attention was paid to identify specific biomarkers for prognosis of patients with cancers [ 11 – 13 ].…”

Section: Introductionmentioning

confidence: 99%

Prognostic role of long non-coding RNA TUG1 expression in various cancers: a meta-analysis

Zhou

et al. 2017

Oncotarget

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Several studies were conducted to explore the prognostic role of long non-coding RNA taurine upregulated gene 1 (lncRNA TUG1) expression in various cancers, with contradictory. This study aims to summarize the prognostic role of lncRNA TUG1 expression in various cancers. Embase, PubMed and Cochrane Library were completely retrieved. The cohort studies focusing on the prognostic role of lncRNA TUG1 expression in various cancers were eligible. The endpoints were overall survival (OS) and clinicopathological parameters. 9 studies involving a total of 1,078 patients were identified. The results showed that high lncRNA TUG1 expression was obviously associated with worse OS when compared to the low lncRNA TUG1 expression (HR = 1.37, 95% CI = 1.07–1.76, P = 0.01; I2 = 85%). However, No distinct relationship was observed between the lncRNA TUG1 expression and age (OR = 0.99, 95% CI = 0.76–1.28, P = 0.92; I2 = 4%), gender (OR = 0.92, 95% CI = 0.70–1.22, P = 0.57; I2 = 0%), diameter (OR = 0.83, 95% CI = 0.34–2.01, P = 0.67; I2 = 85%), smoking (OR = 1.09, 95% CI = 0.37–3.21, P = 0.87; I2 = 73%), TNM stage (OR = 0.60, 95% CI = 0.25–1.43, P = 0.25; I2 = 86%) and lymph node metastasis (OR = 1.07, 95% CI = 0.47–2.45, P = 0.87; I2 = 86%). In conclusion, it was revealed that high lncRNA TUG1 expression is an unfavorable predictor of OS in patients with cancers, and lncRNA TUG1 expression is a promising prognostic biomarker for various cancers.

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Section: Introductionmentioning

confidence: 99%

Prognostic role of long non-coding RNA TUG1 expression in various cancers: a meta-analysis

Zhou

et al. 2017

Oncotarget

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“…Abdel Wahab et al [184] identified 33 deregulated proteins in Egyptian cohort that could be used as a prognostic signature for hepatitis C-virus related HCC. A recent review by Adeola, et al [201] highlights the prospects of using proteomic biomarkers in Africa.…”

Section: Component Of Liquid Biopsymentioning

confidence: 99%

Section: Challenges To Implementation Of Liquid Biopsy Technology mentioning

confidence: 99%

“…Even though liquid biopsy techniques have been used for the diagnosis of various cancer types in the advanced western world [201], its routine clinical use has not received wide coverage in African healthcare settings. This can be due to limiting factors such as lack of skilled personnel, poor health infrastructure, and poor government policies [201]. As a relatively new technology, a potential drawback of liquid biopsy in Africa is that it’s market products would not be affordable to the majority of low-income countries; and it may not be easily available for the general population.…”

Section: Challenges To Implementation Of Liquid Biopsy Technology mentioning

confidence: 99%

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The Prospect and Challenges to the Flow of Liquid Biopsy in Africa

Temilola

Wium

Coulidiati

et al. 2019

Cells

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Liquid biopsy technologies have the potential to transform cancer patient management as it offers non-invasive diagnosis and real-time monitoring of disease progression and treatment responses. The use of liquid biopsy for non-invasive cancer diagnosis can have pivotal importance for the African continent where access to medical infrastructures is limited, as it eliminates the need for surgical biopsies. To apply liquid biopsy technologies in the African setting, the influence of environmental and population genetic factors must be known. In this review, we discuss the use of circulating tumor cells, cell-free nucleic acids, extracellular vesicles, protein, and other biomolecules in liquid biopsy technology for cancer management with special focus on African studies. We discussed the prospect, barriers, and other aspects that pose challenges to the use of liquid biopsy in the African continent.

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“…The cancer can invade bones and lymph nodes and it is the second leading cause of cancer-related mortality in men (1)(2)(3)(4). There are no obvious symptoms when PCa first occurs, however in the later stages the patient will experience difficulty urinating, blood in the urine, or pain in the pelvis or back when urinating.…”

Section: Introductionmentioning

confidence: 99%

Preliminary study on ultrasound-guided prostate biopsy specimen scores

Zhan

Zhang

et al. 2017

Experimental and Therapeutic Medicine

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Abstract. Prostate cancer (PCa) is the second most frequently diagnosed cancer in males worldwide and resulted in ~258,000 cases of cancer-associated mortality in 2008. The present study visually determined the pathology scores of PCa specimens by taking into account five characteristics, including the hardness, color, plumpness, transparency and uniformity of specimens. The current study also aimed to identify the association between pathology scores and prostate specific antigen (PSA) levels, in order to reduce the complications caused by punctures and elevate the specimen positive rates. A total of 1,608 specimens from 268 patients were analyzed by one sonographer, one urologist and one pathologist. A standard pathological examination was performed on the PCa biopsy specimens and specimen scores were recorded under double-blinded conditions. A receiver operator characteristic curve identified a linear correlation between the visually determined score and PSA levels (r=0.255; P<0.001). Furthermore, logistic regression analysis indicated that the visually determined score and PSA were correlated with the diagnosis of PCa. Additionally, the authenticity of the visually determined score was higher than PSA in the diagnosis of PCa, with the best sensitivity and specificity of the visually determined scores used to predict PCa being 0.817 and 0.931, respectively.

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Emerging proteomics biomarkers and prostate cancer burden in Africa

Cited by 23 publications

References 123 publications

Prognostic role of long non-coding RNA TUG1 expression in various cancers: a meta-analysis

Prognostic role of long non-coding RNA TUG1 expression in various cancers: a meta-analysis

The Prospect and Challenges to the Flow of Liquid Biopsy in Africa

Preliminary study on ultrasound-guided prostate biopsy specimen scores

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