Emerging role of Hippo signalling pathway in bladder cancer

Xia, Jianbo; Zeng, Ming; Zhu, Hua; Chen, Xiangjian; Weng, Zhiliang; Shi, Li

doi:10.1111/jcmm.13293

Cited by 33 publications

(31 citation statements)

References 150 publications

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“…Also, regulation of YAP is associated with expression of other cell cycle markers. Not only, in breast, also in other organ such as lung, liver, blood vessels, esophagus and prostate shown similar results [5,[31][32][33][34][35]. Therefore, loss of LATS kinase expression is highly associated with cell proliferation as well as organ size.…”

Section: Down Regulation Of Lats Kinases Serve As Prognostic Factor:-supporting

confidence: 52%

Roles of Large Tumor Suppressor Genes in Breast Cancer.

Lin¹,

Munankarmy²

2017

IJAR

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Section: Down Regulation Of Lats Kinases Serve As Prognostic Factor:-supporting

confidence: 52%

Roles of Large Tumor Suppressor Genes in Breast Cancer.

Lin¹,

Munankarmy²

2017

IJAR

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“…These TFs may play important roles in regulating the transcription of several genes after HOTAIR knockdown, and elucidating the function of these TFs may be crucial toward revealing the pleiotropic functions of HOTAIR. For example, YAP1, which is known to play a role in the development and progression of multiple cancers as a transcriptional regulator of Hippo signaling pathway (71)(72)(73)(74)(75), can interact with 11 other DEGs/ DEPs, suggestion that it may be responsible for the expression changes of some DEGs/DEPs.…”

Section: Discussionmentioning

confidence: 99%

Integrated Proteomic and Transcriptomic Analysis Reveals Long Noncoding RNA HOX Transcript Antisense Intergenic RNA (HOTAIR) Promotes Hepatocellular Carcinoma Cell Proliferation by Regulating Opioid Growth Factor Receptor (OGFr)

Xiong

et al. 2018

Molecular & Cellular Proteomics

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Long noncoding RNA HOX transcript antisense RNA (HOTAIR) is involved in human tumorigenesis and is dysregulated in hepatocellular carcinoma (HCC). However, the molecular mechanisms underlying HOTAIR functions in HCC are largely unknown. Here, we employed an integrated transcriptomic and quantitative proteomic analysis to systematically explore the regulatory role of HOTAIR in HCC. A total of 673 transcripts and 293 proteins were found to be dysregulated after HOTAIR inhibition. Bioinformatics studies indicated that differentially expressed genes (DEGs) and differentially expressed proteins (DEPs) are involved in many biological processes, especially cancer-related signaling pathways. A set of DEGs and DEPs were validated by quantitative RT-PCR, Western blot and parallel reaction monitoring (PRM) analysis, respectively. Further functional studies of the opioid growth factor receptor (OGFr), a negative biological regulator of cell proliferation in HCC, revealed that HOTAIR exerts its effects on cell proliferation, at least in part, through the regulation of OGFr expression. By correlating the omics data with functional studies, the current results provide novel insights into the functional mechanisms of HOTAIR in HCC cells.

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“…Many signaling pathways that affect the survival of bladder cancer cell have been reported, such as MAPK, JAK-STAT, NF-kB, mTOR, et al 2 . Most recently, evolutionarily conserved Hippo pathway has been discovered to play an important role during tumorigenesis and progression of bladder cancer 3 . The Hippo signaling pathway functions via the transcriptional coactivator Yes-associated protein (YAP) to regulate cell growth and migration in mammals 4 , 5 .…”

Section: Introductionmentioning

confidence: 99%

Verteporfin inhibits YAP-induced bladder cancer cell growth and invasion via Hippo signaling pathway

Dong

Fan

et al. 2018

Int. J. Med. Sci.

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The highly conserved Hippo signaling pathway is one of the most important pathways involved in tumorigenesis and progress. Previous studies show that YAP, the transcriptional coactivator of Hippo pathway, is expressed highly in many clinical bladder cancer tissues and plays crucial role on bladder cancer progress. To find the YAP-specific target drug and its molecular mechanism in bladder cancer, we apply Verteporfin (VP), a YAP specific inhibitor to function as anti-bladder cancer drug and discover that VP is able to inhibit bladder cancer cell growth and invasion in a dosage dependent manner. Moreover, we demonstrate that VP may inhibit bladder cancer cell growth and invasion via repressing target genes' expression of the Hippo signaling pathway. In further study, we provide evidence that VP is able to inhibit excessive YAP induced bladder cancer cell growth and invasion. To address the repressive function of VP against YAP in bladder cancer, we check the target genes' expression and find VP can dramatically repress YAP overexpression induced Hippo pathway target genes' expression. Taken together, we discover that VP inhibits YAP-induced bladder cancer cell growth and invasion via repressing the target genes' expression of Hippo signaling pathway.

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Emerging role of Hippo signalling pathway in bladder cancer

Cited by 33 publications

References 150 publications

Roles of Large Tumor Suppressor Genes in Breast Cancer.

Roles of Large Tumor Suppressor Genes in Breast Cancer.

Integrated Proteomic and Transcriptomic Analysis Reveals Long Noncoding RNA HOX Transcript Antisense Intergenic RNA (HOTAIR) Promotes Hepatocellular Carcinoma Cell Proliferation by Regulating Opioid Growth Factor Receptor (OGFr)

Verteporfin inhibits YAP-induced bladder cancer cell growth and invasion via Hippo signaling pathway

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