Emerging role of Jumonji domain-containing protein D3 in inflammatory diseases

Li, Xiang; Chen, Ru-Yi; Shi, Jin-Jin; Li, Chang-Yun; Liu, Yan-Jun; Gao, Chang; Gao, Ming-Rong; Zhang, Shun; Lu, Jian-Fei; Cao, Jia-Feng; Yang, Guan-Jun; Chen, Jiong

doi:10.1016/j.jpha.2024.100978

Journal of Pharmaceutical Analysis

2024

DOI: 10.1016/j.jpha.2024.100978

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Emerging role of Jumonji domain-containing protein D3 in inflammatory diseases

Xiang Li,

Ru-Yi Chen,

Jin-Jin Shi

et al.

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Marine Staurosporine Analogues: Activity and Target Identification in Triple-Negative Breast Cancer

Chen,

Ding,

Liu

et al. 2024

Marine Drugs

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Triple-negative breast cancer (TNBC) is a subtype of breast cancer with high mortality and drug resistance and no targeted drug available at present. Compound 4, a staurosporine alkaloid derived from Streptomyces sp. NBU3142 in a marine sponge, exhibits potent anti-TNBC activity. This research investigated its impact on MDA-MB-231 cells and their drug-resistant variants. The findings highlighted that compound 4 inhibits breast cancer cell migration, induces apoptosis, arrests the cell cycle, and promotes cellular senescence in both regular and paclitaxel-resistant MDA-MB-231 cells. Additionally, this study identified mitogen-activated protein kinase kinase kinase 11 (MAP3K11) as a target of compound 4, implicating its role in breast tumorigenesis by affecting cell proliferation, migration, and cell cycle progression.

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Marine Staurosporine Analogues: Activity and Target Identification in Triple-Negative Breast Cancer

Chen,

Ding,

Liu

et al. 2024

Marine Drugs

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Emerging role of Jumonji domain-containing protein D3 in inflammatory diseases

Cited by 1 publication

References 170 publications

Marine Staurosporine Analogues: Activity and Target Identification in Triple-Negative Breast Cancer

Marine Staurosporine Analogues: Activity and Target Identification in Triple-Negative Breast Cancer

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