Emerging role of let-7 family in the pathogenesis of hematological malignancies

Yazarlou, Fatemeh; Kadkhoda, Sepideh; Ghafouri‐Fard, Soudeh

doi:10.1016/j.biopha.2021.112334

Cited by 24 publications

(8 citation statements)

References 80 publications

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“…However, the prognosis remains poor for some patients, such as those with anaplastic WT, as well as for those with refractory or recurrent WT. These cases pose a signi cant threat to the life and health of children [10,11] . Recent studies suggest that miRNAs are typically downregulated in various tumors, correlating with tumor development, metastasis, and treatment response.…”

Section: Discussionmentioning

confidence: 99%

RETRACTED: MiR-145 modulation of TGF-β pathway attenuates EMT inhibition of Wilms’Tumor cell proliferation, invasion and migration

Zhou,

Wu,

Zhu

et al. 2024

Preprint

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To explore the impact of miR-145 on the proliferation, migration, and invasion of Wilms' tumor G401 cells by attenuating EMT through modulation of the TGF-β pathway.A Wilms' tumor G401 cell line overexpressing miR-145 and a blank control group were established.The proliferation of Wilms' tumor cells was assessed using the CCK8 assay and colony formation experiments.The influence of miR-145 overexpression on the migration and invasion capabilities of these cells was evaluated through Transwell assays.Western blotting was used to analyze the expression of TGF-β pathway-related proteins,EMT-related proteins,and apoptosis-related proteins.Additionally,changes in apoptotic proteins post-treatment with cisplatin were examined via Western blot.An orthotopic Wilms' tumor mouse model was developed to assess the effect of miR-145 overexpression on tumor growth and cisplatin treatment response.CCK8,clonogenic formation,and Transwell assays indicated that miR-145 overexpression group exhibited reduced proliferation,migration,and invasion of Wilms' tumor cells compared to the control.Western blot results demonstrated that miR-145 overexpression suppressed EMT in Wilms' tumor by inhibiting the Smad-mediated TGF-β pathway.MiR-145 significantly induced apoptosis in these cells and improved the therapeutic response to cisplatin,diminishing drug resistance.The orthotopic Wilms' tumor mouse model validated that miR-145 inhibited primary tumor growth in the Wilms' tumor xenograft and enhanced cisplatin treatment response.Taken together,miR-145 inhibits EMT in Wilms' tumor by suppressing the Smad-mediated TGF-β pathway,effectively reducing cell proliferation,migration,and invasion.The miR-145/Smad/TGF-β/EMT axis emerges as a potential therapeutic target for Wilms' tumor.

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Section: Discussionmentioning

confidence: 99%

RETRACTED: MiR-145 modulation of TGF-β pathway attenuates EMT inhibition of Wilms’Tumor cell proliferation, invasion and migration

Zhou,

Wu,

Zhu

et al. 2024

Preprint

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“…Interestingly, we discovered a significant correlation between miR-let-7g and obesity. This miRNA is primarily known as a tumour suppressor that influences the expression of various oncogenic pathways, particularly those associated with c-MYC, and is downregulated in various cancers [ 30 , 31 , 54 ]. However, there is evidence that altered expression of miR-let-7g may play a role in enhancing intramuscular adipogenesis during foetal muscle development, and over-expressing miR-let-7g in cells leads to reduced adipogenic marker expression and fewer adipocytes forming, along with a decrease in inflammatory cytokine expression [ 55 ].…”

Section: Discussionmentioning

confidence: 99%

“…Moreover, it plays a role in maintaining somatic genome integrity by limiting L1 retrotransposition [ 75 ]. Thus, studies have frequently found miR-let-7a as well as miR-let-7g to be downregulated in several cancer types [ 31 , 54 , 76 , 77 ] and to also promote anti-inflammatory factors [ 78 ]. We found no data in the literature on circulating levels of miR-let-7a in the blood of healthy ageing individuals.…”

Section: Discussionmentioning

confidence: 99%

Lifestyle-Driven Variations in Nutrimiromic MicroRNA Expression Patterns across and beyond Genders

Pointner,

Krammer,

Tomeva

et al. 2024

Life

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The importance of diet and lifestyle in maintaining overall health has long been recognised. MicroRNAs (miRNAs) have emerged as key players in the intricate interplay between health and disease. This study, including 305 participants, examined the role of miRNAs from capillary blood as indicators of individual physiological characteristics, diet, and lifestyle influences. Key findings include specific miRNAs associated with inflammatory processes and dietary patterns. Notably, miR-155 was associated with subjects with metabolic diseases and upregulated in age. Additionally, the study revealed diet-related miRNA expressions: high consumption of vegetables, fruits, and whole grains correlated with increased levels of miR-let-7a and miR-328, both implicated in anti-inflammatory pathways, and decreased expression of pro-inflammatory miR-21. In the context of smoking, we found a significant decrease in miRNA-142, known for its downregulation in lung cancer. We observed a sex-biased expression of various miRNAs with significant upregulation of miR-151a in females and a higher expression of miR-155 in ageing females, representing a possible mechanism for the increased susceptibility to autoimmune diseases. In conclusion, the study underscores the significant influence of lifestyle, nutrition, and sex on miRNA profiles. Circulating miRNAs demonstrate significant potential as biomarkers in personalized medicine, highlighting their utility in tailoring healthcare to individual needs.

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“…The overexpression of let-7a in lung cancer cells results in the increased aggressiveness of cells, assessed via an anchorage independent assay and an increase in gene expression associated with cell proliferation, as well as a downregulation of genes associated with adhesion, relevant to tumor progression and metastasis [46]. The let-7 family has been shown to influence the pathogenesis of a variety of hematological malignancies through the changing expression of a number of oncogenic pathways, particularly those related with MYC and that might affect hematopoietic carcinogenesis through the modulation of inflammatory pathways [47].…”

Section: Discussionmentioning

confidence: 99%

The Profile of MicroRNA Expression in Bone Marrow in Non-Hodgkin’s Lymphomas

et al. 2022

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Non-Hodgkin’s lymphomas (NHLs) are a heterogeneous group of malignant lymphomas that can occur in both lymph nodes and extranodal sites. Bone marrow (BM) is the most common site of extranodal involvement in NHL. The objective of this study is to determine the unique profile of miRNA expression in BM affected by NHL, with the possibility of a differential diagnosis of NHL from reactive BM changes and acute leukemia (AL). A total of 180 cytological samples were obtained by sternal puncture and aspiration biopsy of BM from the posterior iliac spine. All the cases were patients before treatment initiation. The study groups were NHL cases (n = 59) and AL cases (acute lymphoblastic leukemia (n = 25) and acute myeloid leukemia (n = 49)); the control group consisted of patients with non-cancerous blood diseases (NCBDs) (n = 48). We demonstrated that expression levels of miRNA-124, miRNA-221, and miRNA-15a are statistically significantly downregulated, while the expression level of let-7a is statistically significantly upregulated more than 2-fold in BM in NHL compared to those in AL and NCBD. ROC analysis revealed that let-7a/miRNA-124 is a highly sensitive and specific biomarker for a differential diagnosis of BM changes in NHL from those in AL and NCBD. Therefore, we conclude that analysis of miRNA expression levels may be a promising tool for early diagnosis of NHL.

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Emerging role of let-7 family in the pathogenesis of hematological malignancies

Cited by 24 publications

References 80 publications

RETRACTED: MiR-145 modulation of TGF-β pathway attenuates EMT inhibition of Wilms’Tumor cell proliferation, invasion and migration

RETRACTED: MiR-145 modulation of TGF-β pathway attenuates EMT inhibition of Wilms’Tumor cell proliferation, invasion and migration

Lifestyle-Driven Variations in Nutrimiromic MicroRNA Expression Patterns across and beyond Genders

The Profile of MicroRNA Expression in Bone Marrow in Non-Hodgkin’s Lymphomas

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