Emerging role of lipophagy in liver disorders

Silibinin ameliorates deoxycholic acid-induced pyroptosis in steatotic HepG2 cells by inhibiting NLRP3 inflammasome activation

“…However, NLRP3 inflammasome activation can also influence autophagy [ 52 ], leading to caspase-1-dependent mitophagy blockade in macrophages, resulting in dysfunctional mitochondria and an exacerbated inflammatory response [ 53 ]. Moreover, balanced autophagy can effectively mitigate lipid accumulation [ 54 , 55 ]. Therefore, we hypothesize that silibinin may selectively inhibit NLRP3 inflammasome activation to exhibit anti-inflammatory effects and alleviate hepatocyte injury in the presence of DCA-induced inflammation in hepatocytes.…”