Emerging role of metabolic reprogramming in hyperoxia-associated neonatal diseases

Genetic Ablation of Pyruvate Dehydrogenase Kinase Isoform 4 Gene Enhances Recovery from Hyperoxic Lung Injury: Insights into Antioxidant and Inflammatory Mechanisms

“…However, some studies have suggested a close association of PDK4 with idiopathic pulmonary fibrosis [22] and idiopathic pulmonary arterial hypertension [23]. Several factors are implicated in the causation of BPD, including exposure to hyperoxia [24,25]. Our data suggest that hyperoxia might have both a direct and an indirect effect on lung tissue due to the convergence of multiple influences.…”

Dysfunction of astrocytic glycophagy exacerbates reperfusion injury in ischemic stroke

“…Many metabolic interactions exist between astrocytes and neurons in the brain [ 17 , 48 ]. Regarding the GSH shuttle, astrocytes can transfer GSH into the extracellular space and convert it into reduced substances with the assistance of astrocytic γ-GT and the neuronal ectopeptidase aminopeptidase N [ 32 , 49 ].…”

Mechanistic advances of hyperoxia-induced immature brain injury

“…Metabolic processes play an important role in hyperoxia-associated neonatal diseases [ 121 ], and the involvement of the gut microbiome in these metabolic processes is receiving increasing attention. Functional metagenomic and metabolomic analyses of hyperoxia-induced gut dysbiosis have shown that hyperoxia leads to gut dysbiosis by eliminating beneficial oxygen-intolerant bacteria, suppresses unsaturated fatty acid metabolism in the gut, and inhibits the hypoxia-inducible factor 1 and glucagon signaling pathways in the serum [ 122 ].…”