Emerging Role of Microbiome in the Prevention of Urinary Tract Infections in Children

Kawalec, Anna; Zwołińska, Danuta

doi:10.3390/ijms23020870

Cited by 28 publications

(19 citation statements)

References 80 publications

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“…In contrast, different immune variants can exacerbate acute and chronic infection or be protective [12,14]. Based on the current knowledge about the pathogenesis of rUTI, there are three main components involved: pathogen virulence, the host's defense mechanism, and the environment [15]. The etiology of UTI includes Gram-positive and Gram-negative bacteria and fungi, but UPEC accounts for a significant proportion of rUTI [6].…”

Section: Pathogenesis Of Rutimentioning

confidence: 99%

Novel Insights on Plant Extracts to Prevent and Treat Recurrent Urinary Tract Infections

Dinu

Vamanu

2022

Applied Sciences

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Urinary tract infections (UTI) represent one of the most widespread infections, and frequent recurrent episodes, induced mostly by uropathogenic Escherichia coli, make them increasingly difficult to treat. Long-term antibiotic therapy is an effective approach to treat recurrent UTI but generates adverse effects, including the emergence of pathogenic strains resistant to the vast majority of antibiotics. These drawbacks have enhanced the interest toward new alternatives based on natural remedies to prevent and treat recurrent UTI, especially in a synergistic antibiotic approach. Therefore, this review highlights the potential of some medicinal plants to be used in the management of recurrent UTI, including plants that have been approved for the treatment of urinary infections and promising, but less studied, plant candidates with proven anti-uropathogenic activity. Pomegranate (Punica granatum L.), black chokeberry (Aronia melanocarpa Michx.), and cornelian cherry (Cornus mas L.) have great potential to be used for prevention or in a combined antibiotic therapy to cure UTI, but more studies and clinical trials in specific population groups are required. Further progress in developing plant-based products to cure rUTI will be supported by advances in UTI pathogenesis and human-based models for a better understanding of their pharmacological activities.

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Section: Pathogenesis Of Rutimentioning

confidence: 99%

Novel Insights on Plant Extracts to Prevent and Treat Recurrent Urinary Tract Infections

Dinu

Vamanu

2022

Applied Sciences

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“…Dysbiosis of the natural microbiota of the urinary tract is related to the development of infections. Under normal conditions, the genitourinary microbiota plays a protective role against urinary tract infections [ 24 ]. Lewis et al [ 25 ] showed that women with low levels of Lactobacillus are more commonly colonized with pathogens than those with diverse microbiota, which naturally decreases the risk of UTI development.…”

Section: Discussionmentioning

confidence: 99%

Organic Acids Secreted by Lactobacillus spp. Isolated from Urine and Their Antimicrobial Activity against Uropathogenic Proteus mirabilis

et al. 2022

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The natural microbiota of the urinary tract includes Lactobacillus spp., which secrete molecules with antimicrobial properties and have antagonistic activity against many pathogens. This paper focuses on the antibacterial effect of Lactobacillus strains isolated from urine against clinical strains of Proteus mirabilis isolated from kidney stones and from urine with coexisting urolithiasis. The study involved analyzing the main antimicrobial molecules secreted by Lactobacillus. In order to indicate which agent had the strongest antimicrobial effect, the supernatants were made alkaline and treated with catalase and high temperature. Both treated and untreated supernatants were analyzed for their activity. Exposing uropathogens to all untreated cell-free supernatants of Lactobacillus significantly reduced their growth, and it was established that these properties were related to organic acid secretion by these strains. Using LC–MS/MS and spectrophotometric techniques, lactic, citric, and succinic acids were determined qualitatively and quantitatively. The influence of these acids on the P. mirabilis growth and biofilm formation and their influence on membrane permeability were also investigated. The results indicate that organic acids secreted by Lactobacillus strains have a high antibacterial potential and could be used as novel agents in the treatment of urinary tract infections caused by P. mirabilis.

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“…The relationship of IM disorders, called dysbiosis, with certain disease development and an increase in human susceptibility to infections has also been determined. 1 - 8 The IM is the largest and crucial microbial community of the human body, which is regarded as a “regulator” of the microbiota of other body areas, and, presumably, as a source of origin of such local communities, including the microbial communities in the urinary tract, also called “urobiome.” 9 - 13 …”

Section: Introductionmentioning

confidence: 99%

Intestinal Microbiota Correction in the Treatment and Prevention of Urinary Tract Infection

Стуров¹,

Popov²,

Zhukov³

et al. 2022

Turkish Journal of Urology

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Intestinal microbiota is a topical subject of modern research. The maintenance of a healthy intestinal microbiota is an important component of homeostasis, and violations of its composition and functions, called dysbiosis, are associated with a number of diseases, including urinary tract infections. Antimicrobial therapy leads to significant changes in the intestinal microbiota and causes the possibility of urinary tract infection recurrence. In this regard, it is important to study methods of microbiota correction in order to restore its structural and functional integrity.

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Emerging Role of Microbiome in the Prevention of Urinary Tract Infections in Children

Cited by 28 publications

References 80 publications

Novel Insights on Plant Extracts to Prevent and Treat Recurrent Urinary Tract Infections

Novel Insights on Plant Extracts to Prevent and Treat Recurrent Urinary Tract Infections

Organic Acids Secreted by Lactobacillus spp. Isolated from Urine and Their Antimicrobial Activity against Uropathogenic Proteus mirabilis

Intestinal Microbiota Correction in the Treatment and Prevention of Urinary Tract Infection

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