Emerging Role of MicroRNAs in Cardiovascular Diseases

Glucose Fluctuations Aggravate Cardiac Susceptibility to Ischemia/Reperfusion Injury by Modulating MicroRNAs Expression

“…MicroRNAs (miRNAs) have recently emerged as key factors in various types of heart diseases. 9, 10 The role of miRNAs in diabetes and its cardiovascular complications has recently attracted considerable attention; 11 however, the link between GF and miRNAs has not yet been elucidated. We explored the involvement of miRNAs in the implicated mechanisms of the effects induced by GF.…”

Atrial Fibrillation-Mediated Upregulation of miR-30d Regulates Myocardial Electrical Remodeling of the G-Protein-Gated K⁺ Channel, <i>I</i>_K.ACh

“…Emerging evidence suggests that miRNAs regulate the genes encoding cardiac ion channels, transporters, Ca 2+ -handling proteins, and other relevant proteins associated with AF substrates and triggers. [19][20][21][22] Although the molecular mechanisms underlying post-transcriptional ion channel remodeling in AF cardiomyocytes remain unresolved, recent studies have pointed out several miRNAs as key regulators of the Ca 2+ current (ICa) and IK1 in AF cardiomyocytes. 13, 14 To date, a pair of miRNAs with an AF history of 6 months or longer, whose age ranged from 60 to 79 years.…”

MicroRNA-93 may control vascular endothelial growth factor A in circulating peripheral blood mononuclear cells in acute Kawasaki disease

“…Although the prevalence and sway of miR-mediated regulation in diverse cellular processes has become increasingly apparent, elucidation of miR regulatory mechanisms is often challenging due in part to miRs commonly exhibiting slight effects on an array of targets. The human genome encodes more than 1000 different miRs that are expressed in a highly dynamic manner in many organs (12)(13)(14). For example, miR-146 and miR-150 regulate NF-κB-related inflammation (15).…”