Emerging Role of miR-345 and Its Effective Delivery as a Potential Therapeutic Candidate in Pancreatic Cancer and Other Cancers

Abstract

Pancreatic ductal adenocarcinoma (PDAC) is an aggressive malignancy with high mortality, poor prognosis, and palliative treatments, due to the rapid upregulation of alternative compensatory pathways and desmoplastic reaction. miRNAs, small non-coding RNAs, have been recently identified as key players regulating cancer pathogenesis. Dysregulated miRNAs are associated with molecular pathways involved in tumor development, metastasis, and chemoresistance in PDAC, as well as other cancers. Targeted treatment strategies that alter miRNA levels in cancers have promising potential as therapeutic interventions. miRNA-345 (miR-345) plays a critical role in tumor suppression and is differentially expressed in various cancers, including pancreatic cancer (PC). The underlying mechanism(s) and delivery strategies of miR-345 have been investigated by us previously. Here, we summarize the potential therapeutic roles of miR-345 in different cancers, with emphasis on PDAC, for miRNA drug discovery, development, status, and implications. Further, we focus on miRNA nanodelivery system(s), based on different materials and nanoformulations, specifically for the delivery of miR-345.

Progressive Changes of Colitis Into Colorectal Cancer Associated With Changes in Neutrophil Lymphocyte Ratio, Serum, Micrornas and Infiltrate Neutrophils

“…In mild stage miR345 is highly express. miR345 is the microRNA that targeting the expression of tumour suppressor gene, activities of peroxisome and ATP generation (13). In moderate stage, miR347 and miR512 is highly express in blood serum.…”

Concern about the Effectiveness of mRNA Vaccination Technology and Its Long-Term Safety: Potential Interference on miRNA Machinery

“…It is reasonable to assume that the disrupted expression of these small molecules can contribute to the onset of other longer-term diseases. The dysregulation of the host miRNA range that modulates multiple gene expressions can influence cancer development, either directly or indirectly [ 43 ]. In fact, different miRNAs can function as oncogenes or tumor-suppressor genes [ 44 ].…”

Silencing the expression of lncRNA SNHG15 may be a novel therapeutic approach in human breast cancer through regulating miR-345-5p

“…Recent evidence suggested that SNHG15 could function as miRNA sponges to inhibit the expression of miRNAs (45). miRNAs play important roles in cell signaling, cell survival, DNA methylation, and invasiveness (46). MiR-345-5p has been shown to regulate the expression of human multidrug resistanceassociated protein 1 (ABCC1/MRP1), suggesting that deregulation of miRNA expression is linked to the cisplatin resistant phenotype (46)(47)(48).…”

“…miRNAs play important roles in cell signaling, cell survival, DNA methylation, and invasiveness (46). MiR-345-5p has been shown to regulate the expression of human multidrug resistanceassociated protein 1 (ABCC1/MRP1), suggesting that deregulation of miRNA expression is linked to the cisplatin resistant phenotype (46)(47)(48). In this study, we found that the effect of SNHG15 knockdown was restored by the inhibition of miR-345-5p, suggesting that overexpression miR-345-5p might play a key role in tumor suppression and cisplatin sensitivity.…”