"Emerging Role of Neutrophils in Wound Healing and Tissue Repair: The Routes of Healing"

Kumar, Rajiv

doi:10.26717/bjstr.2021.36.005877

Cited by 4 publications

(2 citation statements)

References 6 publications

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“…In these circumstances, authors tried their best to prepare a much-needed blueprint that can be a reality soon. A proper understanding of the role neutrophils, inflammatory signaling, and cytokines in brain injuries will be a bullet point during the clinical and physiological investigation of neuroinflammation and chronic diseases [6]. There the elucidation of the phenomenon of the immune system, including monocytes, macrophages, mast cells, neutrophils, basophils, dendritic cells, T-cells, and B-cells initiate redness, heat, swelling, pain, and loss of activity and function of the affected area at the time of infection [7].…”

Section: Opinionmentioning

confidence: 99%

"Brain Ischemia, and Reperfusion Injury: A Clinical and Physiological Investigation of Neuroinflammation and Chronic Neuroinflammatory Diseases"

Kumar

2023

BJSTR

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Section: Opinionmentioning

confidence: 99%

"Brain Ischemia, and Reperfusion Injury: A Clinical and Physiological Investigation of Neuroinflammation and Chronic Neuroinflammatory Diseases"

Kumar

2023

BJSTR

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“…106 With the regulation of cell death and stimulation of cell renewal as a therapeutic target, it is now conceivable to develop novel therapies to regenerate and repair failing myocardium. 107 According to a systematic assessment of the currently available research, the traditional ideas and approaches for defining the control of remodeling are completely inadequate. Failure, neurohormonal remodeling, and the novel cytokine hypothesis cannot adequately explain all cellular and molecular alterations that result in heart failure.…”

Section: Progression Of Cardiac Remodelingmentioning

confidence: 99%

Cholesterol Homeostasis, Mechanisms of Molecular Pathways, and Cardiac Health

Kumar

2023

Preprint

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The metabolism of lipoproteins, which regulates the transit of the lipid to and from tissues, is crucial to maintaining cholesterol homeostasis. Cardiac remodeling is referred to as a set of molecular, cellular, and interstitial changes that, following injury, affect the size, shape, function, mass, and geometry of the heart. Acetyl coenzyme A (acetyl CoA), which can be made from glucose, amino acids, or fatty acids, is the precursor for the synthesis of cholesterol. In this article, authors explain concepts behind cardiac remodeling, its clinical ramifications, and the pathophysiological roles played by numerous various components, such as cell death, neurohormonal activation, oxidative stress, contractile proteins, energy metabolism, collagen, calcium transport, inflammation, and geometry. The levels of cholesterol are traditionally regulated by two biological mechanisms at the transcriptional stage. First, the SREBP transcription factor family regulates the transcription of crucial rate-limiting cholesterogenic and lipogenic proteins, which in turn limits cholesterol production. Immune cells become activated, differentiated, and divided, during an immune response with the objective of eradicating the danger signal. In addition to creating ATP, which is used as energy, this process relies on metabolic reprogramming of both catabolic and anabolic pathways to create metabolites that play a crucial role in regulating the response. Because of changes in signal transduction, malfunction of the sarcoplasmic reticulum and sarcolemma, impairment of calcium handling, increases in cardiac fibrosis, and progressive loss of cardiomyocytes, oxidative stress appears to be the primary mechanism that causes the transition from cardiac hypertrophy to heart failure. De novo cholesterol production, intestinal cholesterol absorption, and biliary cholesterol output are consequently crucial processes in cholesterol homeostasis. In the article's final section, the pharmacological management of cardiac remodeling is explored. The route of treatment is explained into different steps: including, promising, and potential strategies. This chapter offers a brief overview of the history of the study of cholesterol absorption as well as the different potential therapeutic targets.

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