Emerging role of non-coding RNAs in allergic disorders

Ghafouri‐Fard, Soudeh; Shoorei, Hamed; Taheri, Mohammad; Sanak, Marek

doi:10.1016/j.biopha.2020.110615

Cited by 37 publications

(43 citation statements)

References 71 publications

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“…However, their function and molecular mechanism in pulmonary hypertension remains an enigma and awaits further in-depth study. CircRNAs are regarded as competing endogenous RNAs that sequester microRNAs (miRNAs) by complementary base pairing ( Ghafouri-Fard et al, 2020 ; Liu et al, 2020 ). miRNAs are featured as a class of small non-coding RNAs and suppress gene expression by promoting mRNA degradation or inhibiting mRNA translation, and thus, represent novel prospective targets for the diagnosis and therapeutics of various diseases ( Barlak et al, 2020 ).…”

Section: Introductionmentioning

confidence: 99%

Hsa_circ_0002062 Promotes the Proliferation of Pulmonary Artery Smooth Muscle Cells by Regulating the Hsa-miR-942-5p/CDK6 Signaling Pathway

Wang

Tan

et al. 2021

Front. Genet.

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Currently, new strategies for the diagnosis and treatment of hypoxia-induced pulmonary hypertension (HPH) are urgently required. The unique features of circRNAs have unveiled a novel perspective for understanding the biological mechanisms underlying HPH and the possibility for innovative strategies for treatment of HPH. CircRNAs function as competing endogenous RNAs (CeRNA) to sequester miRNAs and regulate the expression of target genes. This study aimed to explore the roles of hsa_circ_0002062 on the biological behaviors of pulmonary artery smooth muscle cells (PASMCs) in hypoxic conditions. A number of in vitro assays, such as RNA-binding protein immunoprecipitation (RIP), RNA pull-down, and dual-luciferase assays were performed to evaluate the interrelationship between hsa_circ_0002062, hsa-miR-942-5P, and CDK6. The potential physiological functions of hsa_circ_0002062, hsa-miR-942-5P, and CDK6 in hypoxic PASMCs were investigated through expression modulation. Our experiments demonstrated that hsa_circ_0002062 functions as a ceRNA, acts as a sponge for hsa-miR-942-5P, and consequently activates CDK6, which further promotes pulmonary vascular remodeling. Therefore, we speculate that hsa_circ_0002062 could serve as a candidate diagnostic biomarker and potential therapeutic target for HPH.

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Section: Introductionmentioning

confidence: 99%

Hsa_circ_0002062 Promotes the Proliferation of Pulmonary Artery Smooth Muscle Cells by Regulating the Hsa-miR-942-5p/CDK6 Signaling Pathway

Wang

Tan

et al. 2021

Front. Genet.

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“…Abundant expressions of lncRNAs were found in T cell lineages, suggesting that these transcripts play important roles in T cell development and differentiation [47]. Studies have found that some lncRNAs play important roles in the pathogenesis of asthma by regulating Th1/Th2 balance and Th2 inflammatory response [3,48]. Understanding how lncRNAs alter gene expression to promote Th2 skewing may provide new insights into mechanisms and therapeutic targets for asthma.…”

Section: Lncrna Regulate Th2 Response In Asthmamentioning

confidence: 99%

“…Non-coding RNAs (ncRNAs) are a class of non-coding RNA molecules widely found in eukaryotes and involved in a variety of biological regulatory processes. They have been extensively studied in human diseases [3][4][5]. NcRNAs mainly includes microRNAs (miRNAs), long non-coding RNAs (lncRNAs), circular RNAs (circRNAs), etc.…”

Section: Introductionmentioning

confidence: 99%

Epigenetic Regulation of Th2 Response in Asthma by Non-Coding RNAs

Niu¹,

Wang²,

Dong³

et al. 2022

Recent Advances in Asthma Research and Treatments

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Asthma is a common chronic inflammatory disease. Pathogenic mechanism underlying asthma is complex. The inflammatory response of asthma includes lymphocytes (T, B cells), ILC2, eosinophils and other types of immune and inflammatory cells. T CD4+ T helper 2 cells (Th2 cells) are thought to play a central role in regulating the phenotype of allergic asthma. Asthma is often closely associated with Th1/Th2 cell imbalance. Non-coding RNAs (ncRNAs) are non-protein coding RNA molecules in the transcriptome, mainly including microRNAs (miRNAs), long non-coding RNAs and circRNAs, etc., which are widely found in eukaryotic transcriptome and participate in the regulation of a variety of biological processes. ncRNAs are considered to function as modulators of the immune system. Their biological changes represent an important mechanism for the development of immune-mediated diseases. This chapter mainly discusses the epigenetic regulation of Th2 cells and their cytokines in asthma by non-coding RNAs. It helps us to better understand the pathogenesis of asthma and find potential asthma biomarkers.

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“…Doğuştan gelen veya adaptif immün yanıtlarında monositler, makrofajlar, DC'ler, nötrofiller, T ve B lenfositleri ncRNA ekspresyonlarını değiştirmektedirler. 31 Ayrıca, ncRNA'ların kanser ve enfeksiyon hastalıkları dahil olmak üzere çeşitli hücresel süreçlerdeki rolü belirlenmiştir. 1 Enfeksiyon sırasında önemli rol oynayan birçok hücresel ncRNA, hem normal fizyolojik koşullarda hem de enfeksiyon sırasında konakçının gen ekspresyonu üzerinde önemli bir etkiye sahiptir.…”

Section: Koronavirüslerin Yapısı Ve Replikasyonuunclassified

“…miRNA'lar ayrıca adaptif immün yanıtlara da katılmakta ve miRNA'ların anormal ekspresyonu, otoimmün bozukluklara sebep olabilmektedir. 31 miRNA'lar T, B ve DC'ler gibi antijen sunan hücrelerinin (APC) gelişimini, olgunlaşmasını ve işlevini düzenleyerek enfeksiyona karşı adaptif yanıtı değiştirmektedir. 41 Örneğin, miRNA-155, kemik iliğindeki hematopoietik kök hücrelerden (HSC) T ve B hücre gelişimini düzenler.…”

Section: Koronavirüslerin Yapısı Ve Replikasyonuunclassified

The Role of ncRNAs in Covid-19 Pathogenesis

Oz¹,

Pehlivan²,

Pirim³

2021

FORBES

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Genomic studies have shown that approximately 2% of the human genome encodes protein, and the rest consists of non-coding RNAs (ncRNA). ncRNAs are the modifications that can alter gene expression at different levels without making any changes on the DNA sequence. One of the most important function of non-coding RNAs is to modulate host immunity and inflammatory response by regulating chromatin structure and gene expression. The World Health Organization has declared Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) as Coronavirus Disease 2019 (COVID-19). COVID-19 shows symptoms such as fever, cough, shortness of breath and it can lead to severe symptomatic acute respiratory distress syndrome (ARDS), bring along many problems such as cardiovascular complications, kidney damage, stroke and death. Virus host interactions associated with the immune system is also important beside the viral replication mechanism in the development of a successful therapeutic target for SARS-CoV-2. Epigenetic mechanisms that regulate virus-host interactions affect the extent and adequacy of immune and inflammatory responses that are important for clinical outcomes. Thus, identifying ncRNAs involved in SARS-CoV-2 infection will help to understand the epigenetic regulation underlying the immune response that occurs and to develop new specific strategies to prevent and treat the infection. In this review, the importance of ncRNA mediated gene regulation in SARS-CoV-2 infection and its role in the ongoing COVID-19 pandemic were discussed.

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Emerging role of non-coding RNAs in allergic disorders

Cited by 37 publications

References 71 publications

Hsa_circ_0002062 Promotes the Proliferation of Pulmonary Artery Smooth Muscle Cells by Regulating the Hsa-miR-942-5p/CDK6 Signaling Pathway

Hsa_circ_0002062 Promotes the Proliferation of Pulmonary Artery Smooth Muscle Cells by Regulating the Hsa-miR-942-5p/CDK6 Signaling Pathway

Epigenetic Regulation of Th2 Response in Asthma by Non-Coding RNAs

The Role of ncRNAs in Covid-19 Pathogenesis

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