Emerging role of regulated cell death in intestinal failure-associated liver disease

Cheng, Siyang; Jiang, Lu; Wang, Ying; Cai, Wei

doi:10.1016/j.hbpd.2022.12.004

Cited by 3 publications

(1 citation statement)

References 64 publications

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“…Furthermore, the transcriptomic analysis showed that different types of programmed cell death were enriched in TPN-treated cells, including apoptosis, necroptosis and ferroptosis. The latter displayed a greater degree of pathway enrichment among the induced cell death pathways, which is in accordance with emerging studies demonstrating an important role for ferroptosis in IFALD pathogenesis (Jiang et al 2022;Cheng et al 2022).…”

Section: Discussionsupporting

confidence: 89%

Investigation of parenteral nutrition-induced hepatotoxicity using human liver spheroid co-cultures

Mihajlovic,

De Boever,

Tabernilla

et al. 2024

Arch Toxicol

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Parenteral nutrition (PN) is typically administered to individuals with gastrointestinal dysfunction, a contraindication for enteral feeding, and a need for nutritional therapy. When PN is the only energy source in patients, it is defined as total parenteral nutrition (TPN). TPN is a life-saving approach for different patient populations, both in infants and adults. However, despite numerous benefits, TPN can cause adverse effects, including metabolic disorders and liver injury. TPN-associated liver injury, known as intestinal failure-associated liver disease (IFALD), represents a significant problem affecting up to 90% of individuals receiving TPN. IFALD pathogenesis is complex, depending on the TPN components as well as on the patient’s medical conditions. Despite numerous animal studies and clinical observations, the molecular mechanisms driving IFALD remain largely unknown. The present study was set up to elucidate the mechanisms underlying IFALD. For this purpose, human liver spheroid co-cultures were treated with a TPN mixture, followed by RNA sequencing analysis. Subsequently, following exposure to TPN and its single nutritional components, several key events of liver injury, including mitochondrial dysfunction, endoplasmic reticulum stress, oxidative stress, apoptosis, and lipid accumulation (steatosis), were studied using various techniques. It was found that prolonged exposure to TPN substantially changes the transcriptome profile of liver spheroids and affects multiple metabolic and signaling pathways contributing to liver injury. Moreover, TPN and its main components, especially lipid emulsion, induce changes in all key events measured and trigger steatosis.

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Section: Discussionsupporting

confidence: 89%

Investigation of parenteral nutrition-induced hepatotoxicity using human liver spheroid co-cultures

Mihajlovic,

De Boever,

Tabernilla

et al. 2024

Arch Toxicol

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Oridonin attenuates liver ischemia–reperfusion injury by suppressing PKM2/NLRP3-mediated macrophage pyroptosis

Wu,

Zhao,

Liao

et al. 2024

Cellular Immunology

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Potential treatment of glutathione in bullfrogs with abnormal hepatic lipid metabolism revealed by hepatic lipid metabolism and serum metabolomics analysis

Su,

Gao,

Shu

et al. 2024

Front. Cell. Infect. Microbiol.

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IntroductionWith the continuous growth of bullfrog supply, it has become an important aquaculture species. Due to the lack of actionable industry standards and regulation, the misuse of anti-disease drugs and abnormal liver lipid metabolism in bullfrogs have become a major obstacle to the development of bullfrog aquaculture industry. Glutathione is a natural tripeptide that can be synthesized intracellularly, and its physiological functions mainly include the treatment of liver diseases, antioxidant, detoxification, anti-tumor, enhancement of immunity, and delaying aging.MethodsIn this study, the therapeutic effect of glutathione on bullfrogs with abnormal liver lipid metabolism was revealed from hepatic lipid metabolism and serum metabolomics analysis. The survival rate, liver histomorphology, serum antioxidant enzyme activity, liver lipase activity and serum metabolomics, liver metabolomics were studied and analyzed by feeding the bullfrogs with abnormal lipid metabolism with glutathione for 20 days in the NC, FI and GSH groups.ResultsThe results of the study showed that glutathione was able to repair the liver and improve the survival rate of bullfrogs with abnormal lipid metabolism; the activity of serum SOD enzymes was significantly increased; the activities of ACP and AKP were significantly decreased; the activities of HDL-C and T-CHO were significantly increased; and the activities of LDL-C, TBA, and TG were significantly decreased in the liver; the contents of metabolites, such as PC, PS, and PE were significantly up-regulated, and the levels of up-regulated Autophagy - other, Necroptosis and ErbB signaling pathway, and down-regulated Sphingolipid metabolism, D-Amino acid metabolism metabolic pathway, to some extent The metabolic pathways of Sphingolipid metabolism and D-Amino acid metabolism were down-regulated to alleviate the disorders of glycerophospholipid and amino acid metabolism to a certain extent, thus alleviating the abnormalities of liver lipid metabolism.DiscussionThe results showed that glutathione could effectively treat the liver lipid metabolism disorder of bullfrogs, promote the growth and development of bullfrogs, repair the liver function, reduce the inflammation, and promote the healthy and green development of bullfrog industry.

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Emerging role of regulated cell death in intestinal failure-associated liver disease

Cited by 3 publications

References 64 publications

Investigation of parenteral nutrition-induced hepatotoxicity using human liver spheroid co-cultures

Investigation of parenteral nutrition-induced hepatotoxicity using human liver spheroid co-cultures

Oridonin attenuates liver ischemia–reperfusion injury by suppressing PKM2/NLRP3-mediated macrophage pyroptosis

Potential treatment of glutathione in bullfrogs with abnormal hepatic lipid metabolism revealed by hepatic lipid metabolism and serum metabolomics analysis

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