Emerging roles and mechanisms of microRNA‑222‑3p in human cancer (Review)

Wang, Danhua; Sang, Yiwen; Sun, Tao; Kong, Piaoping; Zhang, Lingyu; Dai, Yibei; Cao, Ying; Tao, Zhihua; Liu, Weiwei

doi:10.3892/ijo.2021.5200

Cited by 27 publications

(20 citation statements)

References 119 publications

(189 reference statements)

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“…However, miR-222 overexpression did not show prognostic significance in our AML-NK group. This is consistent with recent investigation of miR-222 expression, based on data from the Cancer Genome Atlas that also found that high miR-222 expression did not have significant impact on prognosis, and contrary to the oncogenic role of miR-222, the authors reported that high miR-222 expression seemed to indicate a tendency towards longer survival [ 36 ]. Because of the reported negative correlation between GAS5 and miR-222 expression, we performed analysis of the combined influence of GAS5 and miR-222 expression level on prognosis in AML-NK patients.…”

Section: Discussionsupporting

confidence: 91%

“…It is well documented that miR-222-3p plays various roles in the initiation, progression, metastasis and treatment response of cancer. It is involved in the regulation of multiple tumor signaling pathways, such as PI3K/AKT, PTEN, JAK/STAT, TRPS1/ZEB1 and EMT [ 36 ]. Several studies have shown that its expression could be a target for innovative cancer therapeutic approaches [ 36 , 41 , 42 , 43 ].…”

Section: Discussionmentioning

confidence: 99%

“…It is involved in the regulation of multiple tumor signaling pathways, such as PI3K/AKT, PTEN, JAK/STAT, TRPS1/ZEB1 and EMT [ 36 ]. Several studies have shown that its expression could be a target for innovative cancer therapeutic approaches [ 36 , 41 , 42 , 43 ].…”

Section: Discussionmentioning

confidence: 99%

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Expression Profiles of Long Non-Coding RNA GAS5 and MicroRNA-222 in Younger AML Patients

et al. 2021

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Acute myeloid leukemia (AML) is a heterogeneous malignant disease both on clinical and genetic levels. AML has poor prognosis and, therefore, there is a constant need to find new prognostic markers, as well as markers that can be used as targets for innovative therapeutics. Recently, the search for new biomarkers has turned researchers’ attention towards non-coding RNAs, especially long non-coding RNAs (lncRNAs) and micro RNAs (miRNAs). We investigated the expression level of growth arrest-specific transcript 5 (GAS5) lncRNA in 94 younger AML patients, and also the expression level of miR-222 in a cohort of 39 AML patients with normal karyotype (AML-NK), in order to examine their prognostic potential. Our results showed that GAS5 expression level in AML patients was lower compared to healthy controls. Lower GAS5 expression on diagnosis was related to an adverse prognosis. In the AML-NK group patients had higher expression of miR-222 compared to healthy controls. A synergistic effect of GAS5low/miR-222high status on disease prognosis was not established. This is the first study focused on examining the GAS5 and miR-222 expression pattern in AML patients. Its initial findings indicate the need for further investigation of these two non-coding RNAs, their potential roles in leukemogenesis, and the prognosis of AML patients.

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Section: Discussionsupporting

confidence: 91%

Section: Discussionmentioning

confidence: 99%

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Expression Profiles of Long Non-Coding RNA GAS5 and MicroRNA-222 in Younger AML Patients

et al. 2021

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“…Nonetheless, only HCV/HIV co-infected grafts showed an up-regulation of miR-222, known to play a role in the inhibition of HIV entry in macrophages by targeting CD4 [ 40 ]. miR-222 is also a well-recognized oncogenic miRNA [ 41 ], known to play a role in hepatocellular carcinoma (HCC), by acting on AKT signaling [ 42 , 43 ]. Additionally, it contributes to liver fibrosis by activating stellate cells [ 44 , 45 ].…”

Section: Discussionmentioning

confidence: 99%

“…Additionally, it contributes to liver fibrosis by activating stellate cells [ 44 , 45 ]. Interestingly, it has been displayed that circulating levels of miR-222 correlate with HCC stage and prognosis [ 41 , 42 , 43 ], suggesting that, also in transplanted patients, miR-222 plasma levels could play a role as biomarkers.…”

Section: Discussionmentioning

confidence: 99%

Reinfection of Transplanted Livers in HCV- and HCV/HIV-Infected Patients Is Characterized by a Different MicroRNA Expression Profile

Dalla

Bulfoni

Cesselli

et al. 2022

Cells

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Background: After liver transplantation, HCV/HIV co-infected patients present, compared to the HCV mono-infected ones, increased HCV viral load, rapid progression to liver fibrosis and higher mortality. Liver biopsies (LB), obtained routinely 6 months after transplantation, represent a unique model to assess the early events related to graft re-infection. Here, we used miRNA sequencing of LB obtained from both HCV-and HCV/HIV-infected recipients, to identify transcriptional profiles able to explain the more severe outcome of these latter. Methods: miRNAs of 3 healthy livers, 3 HCV-LB and 3 HCV/HIV-LB were sequenced by Illumina HiSeq2500 platform. The DIANA-miRPath v3.0 webserver and DIANA-microT-CDS algorithm (v5.0) were used to characterize the functions of differentially expressed (DE-) miRNAs, querying the KEGG and Gene Ontology-Biological Process databases. Results: LB obtained from infected patients were characterized, with respect to controls, by a miRNA profile related to viral infection, immune system signaling and DNA damage in HCV-induced carcinogenesis. Instead, HCV-LB and HCV/HIV-LB differed in the expression of miRNAs involved in immunological and apoptotic processes and in extracellular matrix remodeling. Conclusions: liver reinfection processes are associated with early miRNA changes. Further studies are necessary to establish their prognostic role and possible actionability.

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Circulating plasma miR222‐3P status and its potential diagnostic performance in prostate cancer

Heydari

Moudi

Sadeghi

et al. 2022

The Journal of Gene Medicine

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Background: Although studies suggest that miR222-3p is dysregulated in prostate cancer (PC) cells and tissues, the possible changes in the level of miR222-3p in the plasma samples of PC patients remained unclear. The present study aimed to evaluate the diagnostic value of the plasma miR222-3p expression level as a potential biomarker in PC, benign prostatic hyperplasia (BPH) and healthy people.Methods: Blood samples were collected from 100 adult males (54 patients with PC, 27 patients with BPH and 19 healthy individuals) referred to our affiliated hospital.The expression level of miR222-3p was evaluated using a quantitative reverse transcription-polymerase chain reaction. Receiver operating characteristic curves were used to evaluate miR222-3p diagnostic accuracy for discriminating between the PC, BPH and healthy individuals.Results: The expression level of miR222-3p was significantly higher in PC patients compared to healthy individuals as a fold change of 5.3 (p = 0.009), but not for BPH individuals. The diagnostic value of the plasma miR222-3p for discrimination of the PC patients from healthy individuals was reasonable [cut-off value (fold change relative to miR16-5p) = 1.69, area under the curve = 0.73, sensitivity = 0.75 and specificity = 0.74].Conclusions: Circulating plasma miR-222-3p significantly upregulated in PC patients, but not in BPH ones. Besides these preliminary results showed that miR222-3p has the potential to discriminate PC patients from healthy ones. Addittional studies with a larger sample size are required to confirm these data.

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Emerging roles and mechanisms of microRNA‑222‑3p in human cancer (Review)

Cited by 27 publications

References 119 publications

Expression Profiles of Long Non-Coding RNA GAS5 and MicroRNA-222 in Younger AML Patients

Expression Profiles of Long Non-Coding RNA GAS5 and MicroRNA-222 in Younger AML Patients

Reinfection of Transplanted Livers in HCV- and HCV/HIV-Infected Patients Is Characterized by a Different MicroRNA Expression Profile

Circulating plasma miR222‐3P status and its potential diagnostic performance in prostate cancer

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