Emerging roles for Interleukin-11 in disease

Nguyen, Paul M.; Abdirahman, Suad M; Putoczki, Tracy L.

doi:10.1080/08977194.2019.1620227

Cited by 35 publications

(22 citation statements)

References 77 publications

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“…IL-6 family cytokines have been shown to bind to gp130 alone [10][11][12] , although the accepted mode of signaling requires the interaction of cytokines with a specific, high-affinity receptor subunit (alpha chain) prior to binding to gp130 13 . The gp130 receptor subsequently triggers a number of different pathways, including canonical JAK/STAT signaling, as well as ERK and AKT 14,15 . Loss-of-function mutations in IL-6 family cytokines or receptors result in a diverse set of genetic disorders of varying severity [16][17][18][19] , which suggests nonredundant and distinct biological functions of members of this cytokine family.…”

Section: Il-11 Is a Member Of The Il-6 Family Of Cytokinesmentioning

confidence: 99%

Interleukin-11 signaling underlies fibrosis, parenchymal dysfunction, and chronic inflammation of the airway

Cook

Schäfer

2020

Exp Mol Med

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Interleukin (IL)-11 evolved as part of the innate immune response. In the human lung, IL-11 upregulation has been associated with viral infections and a range of fibroinflammatory diseases, including idiopathic pulmonary fibrosis. Transforming growth factor-beta (TGFβ) and other disease factors can initiate an autocrine loop of IL-11 signaling in pulmonary fibroblasts, which, in a largely ERK-dependent manner, triggers the translation of profibrotic proteins. Lung epithelial cells also express the IL-11 receptor and transition into a mesenchymal-like state in response to IL-11 exposure. In mice, therapeutic targeting of IL-11 with antibodies can arrest and reverse bleomycin-induced pulmonary fibrosis and inflammation. Intriguingly, fibroblast-specific blockade of IL-11 signaling has anti-inflammatory effects, which suggests that lung inflammation is sustained, in part, through IL-11 activity in the stroma. Proinflammatory fibroblasts and their interaction with the damaged epithelium may represent an important but overlooked driver of lung disease. Initially thought of as a protective cytokine, IL-11 is now increasingly recognized as an important determinant of lung fibrosis, inflammation, and epithelial dysfunction.

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Section: Il-11 Is a Member Of The Il-6 Family Of Cytokinesmentioning

confidence: 99%

Interleukin-11 signaling underlies fibrosis, parenchymal dysfunction, and chronic inflammation of the airway

Cook

Schäfer

2020

Exp Mol Med

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“…In this case, the Janus kinase-signal transducer and activator of transcription (JAK-STAT) signaling pathway is activated, and it participates in various biological processes, such as cell proliferation, migration, differentiation, apoptosis, and immune regulation in the body. 18,19 According to recent studies, IL-11 expression in gastric cancer, breast cancer, and other tumors have a significant correlation with STAT3 activation in epithelial Data were expressed as number and median (IQR, 25th-75th). CEA: carcinoembryonic antigen; HRR: hemoglobin-to-red blood cell distribution width ratio; IL: interleukin; IQR: interquartile range; LMR: lymphocyteto-monocyte ratio; NLR: neutrophil-to-lymphocyte ratio; NSE: neuron-specific enolase; SCC: squamous cell carcinoma antigen.…”

Section: Discussionmentioning

confidence: 99%

Clinical value of serum and exhaled breath condensate inflammatory factor IL-11 levels in non-small cell lung cancer: Clinical value of IL-11 in non-small cell lung cancer

Chen

et al. 2021

Int J Biol Markers

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Objective: Our study aimed to observe and evaluate the clinical value of interleukin (IL)-11 in the serum and exhaled breath condensate of patients with non-small cell lung cancer (NSCLC). Methods: A total of 91 patients with NSCLC and 72 healthy volunteers were included in this study. IL-11 concentration was determined by ELISA, and the relationship between IL-11 expression in serum and exhaled breath condensate specimens, and the clinicopathological characteristics of patients with NSCLC were analyzed. The relationship between serum IL-11 expression and traditional tumor markers and inflammation indicators of NSCLC was also analyzed. The correlation between serum IL-11 and exhaled breath condensate IL-11 level was determined. The receiver operating characteristic curve was used to evaluate the diagnostic value of IL-11 and carcinoembryonic antigen single and combined detection for NSCLC. The published data from online databases were used to analyze the relationship between the expression of IL-11 and the prognosis of NSCLC. Results: IL-11 concentration in serum and exhaled breath condensate specimens of patients with NSCLC were significantly increased. IL-11 expression was positively correlated with lymph node metastasis, distant metastasis, tumor node metastasis stage, and tumor differentiation degree of NSCLC. The expression of IL-11 in serum was positively correlated with that in exhaled breath condensate specimens. IL-11 expression was closely related to that of neutrophil-to-lymphocyte ratio and carcinoembryonic antigen. The combination of serum IL-11 with exhaled breath condensate IL-11 and carcinoembryonic antigen showed significantly higher diagnostic value than any one marker alone. Besides, the high IL-11 expression was closely related to the poor prognosis of NSCLC. Conclusion: IL-11 can be used as a potential diagnostic and prognostic biomarker for NSCLC.

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“…***P < .001 IL-11 and its receptor (IL-11RA) were expressed specifically in fibroblasts, in which they drive non-canonical, ERK-dependent autocrine signaling and was required for fibrosis protein synthesis. 27 To further explore the role of miR-10396b-3p in the pathogenesis of LF hypertrophy, we performed functional analysis of miR-10396b-3p to | 13 of 17…”

Section: Discussionmentioning

confidence: 99%

“…IL‐11, a major member of the IL‐6 proteins family, was involved in the production of ECM in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes 26 . IL‐11 and its receptor (IL‐11RA) were expressed specifically in fibroblasts, in which they drive non‐canonical, ERK‐dependent autocrine signaling and was required for fibrosis protein synthesis 27 . To further explore the role of miR‐10396b‐3p in the pathogenesis of LF hypertrophy, we performed functional analysis of miR‐10396b‐3p to investigate the relationship between miR‐10396b‐3p and fibrosis expressions.…”

Section: Discussionmentioning

confidence: 99%

miR‐10396b‐3p inhibits mechanical stress‐induced ligamentum flavum hypertrophy by targeting IL‐11

Qian

Zheng

et al. 2021

The FASEB Journal

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Lumbar spinal stenosis (LSS) is a common condition in elderly patients, which is associated with back pain, lower extremity pain, and neurogenic claudication owing to degenerative changes. 1 Ligamentum flavum hypertrophy (LFH) has been considered as a major cause of LSS development. 2 LFH results from ligamentum flavum tissue fibrosis brought about by inflammation and stress. [3][4][5][6][7] Pathological LFH exhibits the loss of elastic fibers and an increase in collagen fibers, suggesting the fibrotic changes. 3 Several inflammatory cytokines, including transforming growth factor-β1 (TGF-β1),

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Emerging roles for Interleukin-11 in disease

Cited by 35 publications

References 77 publications

Interleukin-11 signaling underlies fibrosis, parenchymal dysfunction, and chronic inflammation of the airway

Interleukin-11 signaling underlies fibrosis, parenchymal dysfunction, and chronic inflammation of the airway

Clinical value of serum and exhaled breath condensate inflammatory factor IL-11 levels in non-small cell lung cancer: Clinical value of IL-11 in non-small cell lung cancer

miR‐10396b‐3p inhibits mechanical stress‐induced ligamentum flavum hypertrophy by targeting IL‐11

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