“…This approach protects the transgene from the cis-control of the host and from individual trans-control, whereas the expression of the transgene can be blocked during the more general form of chromatin remodeling. However, the remodeling of chromatin by such a general transforming principle (e.g., a plant oncogene of a Ti-plasmid) can result in the over-expression of certain sets of host genes (Bulgakov et al, 2009;Zhuravlev et al, 1990). The slow cis-control of host DNA (DNA reparation) can destroy the transgene because mutations seem to occur more often in the transgene that in the host DNA (Kiselev et al, 2009).…”