Emerging Roles of Ceramide in Cardiovascular Diseases

Shu, Hongyang; Peng, Yizhong; Hang, Weijian; Li, Na; Zhou, Ning; Wang, Dao Wen

doi:10.14336/ad.2021.0710

Cited by 32 publications

(28 citation statements)

References 135 publications

(143 reference statements)

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“…The different vascular effects may result from the different types of vessels and their various diameters, as well as the cell types they act on. Notably, different lengths of ceramides have different pathological functions ( 87 ).…”

Section: Ceramides and Vesselsmentioning

confidence: 99%

“…Furthermore, previous studies have provided clear evidence that sphingolipids, particularly ceramides, have an important role in T1DM and the complications of T2DM ( 89 , 90 ). Indeed, several metabolic diseases, including DM, cardiomyopathy, insulin resistance and atherosclerosis, can be treated by preventing ceramide production or accelerating ceramide breakdown ( 87 ).…”

Section: Ceramides and Diabetesmentioning

confidence: 99%

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Role of ceramides in diabetic foot ulcers (Review)

et al. 2023

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diabetes mellitus (dM) is a metabolic disorder, which if not managed properly, can lead to serious health problems over time and impose significant financial burden on the patient, their family and society as a whole. The study of this disease and the underlying biological mechanism is gaining momentum. Multiple pieces of conclusive evidence show that ceramides are involved in the occurrence and development of diabetes. The present review focuses on the function of ceramides, a type of sphingolipid signaling molecule, to provide a brief description of ceramides and their metabolism, discuss the significant roles of ceramides in the healthy skin barrier, and speculate on the potential involvement of ceramides in the pathogenesis and development of diabetic foot ulcers (dFUs). Understanding these aspects of this disease more thoroughly is crucial to establish how ceramides contribute to the etiology of diabetic foot infections and identify possible therapeutic targets for the treatment of dFUs. Contents1. Introduction 2. Biosynthesis and degradation of ceramides 3. Ceramides in the skin 4. ceramides and dFUs 5. ceramides and vessels 6. ceramides and diabetes 7. ceramides and atherosclerosis 8. Mechanism of ceramides in diabetes 9. Mechanism of ceramides in atherosclerosis 10. Shared mechanisms between diabetic complications and dFUs 11. conclusions

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Section: Ceramides and Vesselsmentioning

confidence: 99%

Section: Ceramides and Diabetesmentioning

confidence: 99%

Role of ceramides in diabetic foot ulcers (Review)

et al. 2023

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“…Together with SM, Cers are essential constituents of the cell membrane, participating in cell signaling regulating the localization and activation of membrane-associated receptors [ 45 ]. Cers are involved in several biological activities that influence the pathophysiology of CVDs, with effects on apoptosis, oxidative stress, inflammation, endothelial dysfunction, insulin resistance, and lipotoxicity [ 46 , 47 ]. For this reason, Cer modulation has been correlated to various pathological conditions, particularly those affecting the CV system.…”

Section: Ceramide and Sphingosine 1-phosphate In Cardiovascular Physi...mentioning

confidence: 99%

Sex Differences in Cardiovascular Diseases: A Matter of Estrogens, Ceramides, and Sphingosine 1-Phosphate

Arosio

Corbi

Davinelli

et al. 2022

IJMS

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The medical community recognizes sex-related differences in pathophysiology and cardiovascular disease outcomes (CVD), culminating with heart failure. In general, pre-menopausal women tend to have a better prognosis than men. Explaining why this occurs is not a simple matter. For decades, sex hormones like estrogens (Es) have been identified as one of the leading factors driving these sex differences. Indeed, Es seem protective in women as their decline, during and after menopause, coincides with an increased CV risk and HF development. However, clinical trials demonstrated that E replacement in post-menopause women results in adverse cardiac events and increased risk of breast cancer. Thus, a deeper understanding of E-related mechanisms is needed to provide a vital gateway toward better CVD prevention and treatment in women. Of note, sphingolipids (SLs) and their metabolism are strictly related to E activities. Among the SLs, ceramide and sphingosine 1-phosphate play essential roles in mammalian physiology, particularly in the CV system, and appear differently modulated in males and females. In keeping with this view, here we explore the most recent experimental and clinical observations about the role of E and SL metabolism, emphasizing how these factors impact the CV system.

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“…They are synthesized by six different ceramide synthases and represent the scaffold for complex sphingolipids, e.g., sphingomyelin and the glycosphingolipids [ 41 ]. Ceramides perform important biological roles, being implicated in the signalling pathways that are associated with various cellular processes, such as cell growth, differentiation, and apoptosis [ 42 ]. They have also been shown to be involved in the pathophysiological mechanisms of a large array of human diseases, including atherosclerosis and cardiovascular disease (CVD), insulin resistance and type 2 diabetes mellitus, neurodegenerative disorders, etc.…”

Section: Lipid and Lipoprotein Profile Markersmentioning

confidence: 99%

“…Ceramides are produced in higher amounts in vascular endothelial cells in patients with atherosclerosis, and they lead to decreased NO (nitric oxide) production and the impairment of endothelium-derived vasorelaxation, thus contributing to the arterial dysfunction that is associated with CVD [ 50 ]. Ceramides are also involved in the chronic inflammation that is associated with the atherosclerotic process by promoting the production of C-reactive protein (CRP) and interleukin-6 (IL-6) [ 42 ].…”

Section: Lipid and Lipoprotein Profile Markersmentioning

confidence: 99%

Circulating Biomarkers for Laboratory Diagnostics of Atherosclerosis—Literature Review

et al. 2022

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Atherosclerosis is still considered a disease burden with long-term damaging processes towards the cardiovascular system. Evaluation of atherosclerotic stages requires the use of independent markers such as those already considered traditional, that remain the main therapeutic target for patients with atherosclerosis, together with emerging biomarkers. The challenge is finding models of predictive markers that are particularly tailored to detect and evaluate the evolution of incipient vascular lesions. Important advances have been made in this field, resulting in a more comprehensible and stronger linkage between the lipidic profile and the continuous inflammatory process. In this paper, we analysed the most recent data from the literature studying the molecular mechanisms of biomarkers and their involvement in the cascade of events that occur in the pathophysiology of atherosclerosis.

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Emerging Roles of Ceramide in Cardiovascular Diseases

Cited by 32 publications

References 135 publications

Role of ceramides in diabetic foot ulcers (Review)

Role of ceramides in diabetic foot ulcers (Review)

Sex Differences in Cardiovascular Diseases: A Matter of Estrogens, Ceramides, and Sphingosine 1-Phosphate

Circulating Biomarkers for Laboratory Diagnostics of Atherosclerosis—Literature Review

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