Emerging roles of circular RNAs in non‑small cell lung cancer (Review)

Li, Shanshan; Liu, Yize; Qiu, Guanzhen; Luo, Yinzhou; Li, Xiang; Meng, Fei; Li, Nanyang; Xu, Tiance; Wang, Yong; Qin, Baoli; Xia, Shunren

doi:10.3892/or.2021.7968

Cited by 15 publications

(14 citation statements)

References 102 publications

(120 reference statements)

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“…1,22 Over the past decades, numerous studies have facilitated novel biomarker and effective targets exploration in NSCLC, which unveiled a large number of abnormal expressions of circRNAs involved in lung cancer pathogenesis. [23][24][25] In particular, it has been proposed that circRNAs could function as competing endogenous RNAs (ceRNA) to interact with miRNAs (typically absorb miRNA expression like a sponge). [25][26][27][28][29] Here hsa_circ_0088036 was found to be aberrantly elevated in peripheral blood mononuclear cells from patients with RA.…”

Section: Discussionmentioning

confidence: 99%

Hsa_circ_0088036 promotes nonsmall cell lung cancer progression by regulating miR‐1343‐3p/Bcl‐3 axis through TGFβ/Smad3/EMT signaling

Chen

Liu

et al. 2023

Molecular Carcinogenesis

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Nonsmall cell lung cancer (NSCLC) is the leading cause of cancer‐related mortality worldwide. Circular RNAs (circRNAs) have been the focus of numerous studies, and some circRNAs have been linked to the development of multiple malignant tumors, including NSCLC. Nevertheless, the functional role and mechanisms of circRNAs in NSCLC remain largely unknown. The primary objective of this study was to screen the associated circRNA in NSCLC and investigate its mechanism. CircRNA microarray was used to identify circRNAs that were abnormally expressed in NSCLC tissue samples. Expression of hsa_circRNA_0088036 was validated in NSCLC tissues and cell lines after the correlation between hsa_circRNA_0088036 and prognosis was determined. We then used a series of function gain‐and‐loss assays to determine the role of hsa_circ_0088036 in NSCLC progression. RNA‐binding protein immunoprecipitation (RIP), RNA pull‐down, and RNA interference assays were used to assess the interaction between hsa_circ_0088036 and miR‐1343‐3p/Bcl‐3 axis. Moreover, mechanistic assays were applied to investigate the involved signaling pathway regulated by the hsa_circ_0088036/miR‐1343‐3p/Bcl‐3 axis. Microarray analysis and reverse transcription polymerase chain reaction confirmed the presence of a circRNA termed hsa_circ 0088036 that was upregulated in NSCLC tissue samples and cell lines and indicated a positive association with patient prognosis. Functionally, hsa_circ_0088036 silencing inhibited proliferative, invasive, and migrative potential of NSCLC cells as well as epithelial‐mesenchymal transition (EMT)‐related proteins by sponging miR‐1343‐3p to inhibit Bcl‐3. Furthermore, mechanistic experiments demonstrated that hsa_circ_0088036 promoted NSCLC progression by activating the TGFβ/Smad3/EMT signaling pathway via miR‐1343‐3p/Bcl‐3 axis. In conclusion, hsa_circ_0088036 functions as an oncogene by targeting the miR‐1343‐3p/Bcl‐3 axis via TGFβ/Smad3/EMT signaling pathway.

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Section: Discussionmentioning

confidence: 99%

Hsa_circ_0088036 promotes nonsmall cell lung cancer progression by regulating miR‐1343‐3p/Bcl‐3 axis through TGFβ/Smad3/EMT signaling

Chen

Liu

et al. 2023

Molecular Carcinogenesis

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“…CircRNAs can influence NSCLC drug resistance through the ‘sponge’ miRNA model, binding to RBPs and/or regulating the translation of their parental genes ( 66 ).…”

Section: Circrnas and Resistance To Adjuvant Therapy In Lung Cancermentioning

confidence: 99%

Role of circular RNAs in the diagnosis, regulation of drug resistance and prognosis of lung cancer (Review)

Sang

Rao

et al. 2022

Oncol Lett

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Lung cancer is one of the most common malignant tumors in China and is the highest cause of mortality among male and female patients, both in urban and rural areas. A subset of patients with lung cancer only display chest tightness without any other obvious symptoms. This is because most symptoms do not manifest during the early stages of disease development. Consequently, most patients with lung cancer are diagnosed when the disease is in the advanced stages, when they are already unfit for surgical treatment. Furthermore, the prognosis of patients with lung cancer is poor. The 5-year survival rate of patients with stage IA lung cancer is 85%, compared with 6% in those with stage IV. This requires the development of strategies for early diagnosis, treatment and prognosis to improve the management of lung cancer. Circular RNAs (circRNAs) belong to a class of closed circular non-coding RNAs formed by reverse splicing of a precursor mRNA. These RNAs are highly stable, ubiquitously expressed, conserved, and show high specificity. CircRNAs regulate biological processes, such as the proliferation, differentiation and invasion of lung cancer cells. Therefore, they can be used as biomarkers for the early diagnosis and prognosis prediction of lung cancer, as well as novel targets for therapy design. In the present review, the biological characteristics and functions of circRNAs, as well as their application in the diagnosis, control of drug resistance and effect on the prognosis of patients with lung cancer, will be discussed. Contents1. Introduction 2. Classification and characteristics of circRNAs 3. Biological characteristics of circRNAs 4. Biological functions of circRNAs 5. Lab/experimental protocols for the detection of circRNAs 6. Diagnostic significance of circRNAs in lung cancer 7. CircRNAs and resistance to adjuvant therapy in lung cancer 8. CircRNAs and the prognosis of patients with lung cancer 9. Limitations of circRNAs as diagnostic markers for lung cancer 10. Conclusion

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“…CircRNAs have multiple functional modes, one of which is the competitive absorption of microRNAs (miRNAs) 10 . circRNA–miRNA–mRNA interaction networks have been widely noticed in the tumorigenesis and invasive progression of NSCLC 11 . For example, circ‐Mediator of cell motility 1 (circ‐MEMO1)/miR‐101‐3p/Kirsten rat sarcoma viral oncogene axis induces NSCLC progression and glycolysis 12 and circ‐paired like homeodomain 1/miR‐30 e‐5p/Integrin 6 axis stimulates epithelial‐mesenchymal transition (EMT) in NSCLC 13 .…”

Section: Introductionmentioning

confidence: 99%

“…10 circRNA-miRNA-mRNA interaction networks have been widely noticed in the tumorigenesis and invasive progression of NSCLC. 11 For example, circ-Mediator of cell motility 1 (circ-MEMO1)/miR-101-3p/ Kirsten rat sarcoma viral oncogene axis induces NSCLC progression and glycolysis 12 and circ-paired like homeodomain 1/miR-30 e-5p/Integrin 6 axis stimulates epithelial-mesenchymal transition (EMT) in NSCLC. 13 We predicted circSEC61A1-related miRNA (miR-513a-5p) and mRNA (peroxisomal biogenesis factor 5, PEX5).…”

mentioning

confidence: 99%

Circular RNA Sec61 subunit alpha isoform 1 by competitive absorption of microRNA‐513a‐5p mediates peroxisomal biogenesis factor 5 expression and promotes the malignant phenotype of non‐small cell lung cancer

Duan¹,

Yu²,

Wei³

2022

The Kaohsiung J of Med Scie

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Circular RNAs (circRNAs) are functional RNAs in the development and metabolism of non-small cell lung cancer (NSCLC). Therein, this paper particularly elucidated the circRNA SEC61 subunit alpha isoform 1 (circSEC61A1) in NSCLC has not been fully elucidated.Clinical analysis of circSEC61A1 expression was performed on specimens collected from 51 patients with primary NSCLC, together with patients' survival. Cell experiments were performed after interfering with circSEC61A1, microRNA (miR)-513a-5p, and peroxisomal biogenesis factor 5 (PEX5) expression, respectively, and cell malignant phenotypes and aerobic glycolysis were evaluated, as well as epithelial-to-mesenchymal transition (EMT)-related markers and Wnt/β-catenin pathway. Xenografts experiments studied the performance of circSEC61A1 in vivo. The downstream molecules of circSEC61A1 were searched. Our data demonstrated that circSEC61A1 was upregulated in NSCLC patients, showing an association with poorer survival outcomes. In cell experiments, cir-cSEC61A1 overexpression promoted NSCLC malignant phenotypes, glycolysis, EMT, and Wnt/β-catenin pathway activation, whereas circSEC61A1 underexpression did the opposite. Knockdown of circSEC61A1 limited tumor growth and metastasis. Furthermore, circSEC61A1 could regulate PEX5 expression through competitive absorption of miR-513a-5p. Generally, circSEC61A1 is a potential biomarker for NSCLC, and cir-cSEC61A1 serves tumor-promoting action in the progression of NSCLC.

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Emerging roles of circular RNAs in non‑small cell lung cancer (Review)

Cited by 15 publications

References 102 publications

Hsa_circ_0088036 promotes nonsmall cell lung cancer progression by regulating miR‐1343‐3p/Bcl‐3 axis through TGFβ/Smad3/EMT signaling

Hsa_circ_0088036 promotes nonsmall cell lung cancer progression by regulating miR‐1343‐3p/Bcl‐3 axis through TGFβ/Smad3/EMT signaling

Role of circular RNAs in the diagnosis, regulation of drug resistance and prognosis of lung cancer (Review)

Circular RNA Sec61 subunit alpha isoform 1 by competitive absorption of microRNA‐513a‐5p mediates peroxisomal biogenesis factor 5 expression and promotes the malignant phenotype of non‐small cell lung cancer

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