Emerging roles of ferroptosis in glioma

Shi, Jiaqi; Yang, Ning; Han, Mingzhi; Qiu, Chen

doi:10.3389/fonc.2022.993316

Cited by 11 publications

(7 citation statements)

References 206 publications

(245 reference statements)

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“…Furthermore, the breakdown of ferritin, accomplished through ferritinophagy, has the potential to liberate stored iron, contributing to the initiation of ferroptosis. Consequently, the finely tuned control of ferritin levels and functions, influenced by factors like the expression of FTH and FTL subunits, emerges as a pivotal determinant influencing cellular susceptibility to ferroptotic cell demise (Chen, Yu, et al, 2020; Shi et al, 2022).…”

Section: Overview Of Ferroptosis In Cancermentioning

confidence: 99%

Induction of ferroptosis by natural phenols: A promising strategy for cancer therapy

Zhang,

Xie

2024

Phytotherapy Research

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In recent years, heightened interest surrounds the exploration of natural phenols as potential agents for cancer therapy, specifically by inducing ferroptosis, a unique form of regulated cell death characterized by iron‐dependent lipid peroxidation. This review delves into the roles of key natural phenols, flavonoids, phenolic acids, curcumin, and stilbenes, in modulating ferroptosis and their underlying mechanisms. Emphasizing the significance of amino acid, lipid, and iron metabolism, the study elucidates the diverse pathways through which these phenols regulate ferroptosis. Notably, curcumin, a well‐known polyphenol, exhibits multifaceted interactions with cellular components involved in ferroptosis regulation, providing a distinctive therapeutic avenue. Stilbenes, another phenolic class, demonstrate promising potential in influencing lipid metabolism and iron‐dependent processes, contributing to ferroptotic cell death. Understanding the intricate interplay between these natural phenols and ferroptosis not only illuminates complex cellular regulatory networks but also unveils potential avenues for novel cancer therapies. Exploring these compounds as inducers of ferroptosis presents a promising strategy for targeted cancer treatment, capitalizing on the delicate balance between cellular metabolism and regulated cell death mechanisms. This article synthesizes current knowledge, aiming to stimulate further research into the therapeutic potential of natural phenols in the context of ferroptosis‐mediated cancer therapy.

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Section: Overview Of Ferroptosis In Cancermentioning

confidence: 99%

Induction of ferroptosis by natural phenols: A promising strategy for cancer therapy

Zhang,

Xie

2024

Phytotherapy Research

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“…NF-κB has relationships to subunits linked to poorer outcomes at the RNA level and longer survival at the protein level, while Notch signaling was tumor-promoting overall [18,23] with evolving directionality with respect to the protein level. Ferroptosis, a novel mechanism of cell death, has been increasingly described in glioma with connections to the lipidome and known mediators, including p53 and MAPK, and iron metabolism [33,34]. It is increasingly associated with adaptive resistance mechanisms and may be employed in future therapeutic avenues [35].…”

Section: Emerging Pathway and Omic Signatures In Gliomamentioning

confidence: 99%

Attributing Meaning to Molecular Interaction Networks by Leveraging Clinical and Omic Data: The Missing Link between Tumor Biology and Treatment Strategies in Glioma

V. Krauze

2023

Molecular Biology and Treatment Strategies for Gliomas

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The pace of data growth in the molecular space has led to the evolution of sophisticated approaches to data aggregation and linkages, such as IPA, STRING, KEGG, and others. These tools aim to generate molecular interaction networks harnessing growing molecular data at all levels to link tumor biology knowledge to signaling pathways and matched analyses. Potentially actionable biomarkers, however, are evaluated based on clinically associated prognosis, and necessary computational approaches should be vetted for interpretability through a clinical lens. Intersectional clinical and computational expertise is needed to link omics, molecular interactions, and clinical data to address the missing link between tumor biology and treatment strategies.

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“…Ferroptosis is mainly due to redox imbalance and involves several intracellular biological processes, such as iron metabolism, lipid metabolism, and antioxidant synthesis (Zhao et al, 2022). Induction of ferroptosis may be a novel target for glioma treatment, and ferroptosis-related processes are associated with chemo-and radioresistance in glioma (Shi et al, 2022).…”

Section: Introductionmentioning

confidence: 99%

Impact of ferroptosis-related risk genes on macrophage M1/M2 polarization and prognosis in glioblastoma

Xu,

Zhang,

Liao

et al. 2024

Front. Cell. Neurosci.

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ObjectiveTo explore the effect impact of ferroptosis on macrophage polarization and patient prognosis in glioblastoma.MethodsWe screened ferroptosis-related risk from the public datasets of primary and recurrent glioblastoma, combined with reported ferroptosis genes, calculated the risk genes among the ferroptosis-related genes using the LASSO Cox regression model, and investigated the relationship between these ferroptosis-related risk genes in the tumor and the spectrum of infiltrating M1/M2 macrophages. Macrophages were analyzed using the CIBERSORTx deconvolution algorithm. Samples from The Cancer Genome Atlas (TCGA), Chinese Glioma Genome Atlas (CGGA) and a single-cell RNA sequencing dataset (GSE84465) were included. The expression levels of ferroptosis-related risk genes and molecular markers of M1 and M2 macrophages were detected by qPCR and western blot.ResultsA total of fourteen ferroptosis-related risk genes were obtained and the patients’ risk scores were calculated. Compared with patients in the low-risk group, patients in the high-risk group had worse prognosis. The M1/M2 macrophage ratio and risk score were negatively correlated, indicating that the tumor microenvironment of glioblastoma in the high-risk group contained more M2 than M1 macrophages. In the single-cell RNA sequencing dataset, the risk score of ferroptosis-related genes in tumor cells was positively correlated with the proportion of high M2 macrophages. The expression of eight ferroptosis-related risk genes was increased in glioblastoma cell, which promoted the polarization of M1 macrophages to M2.ConclusionWe investigated the fourteen ferroptosis-related risk genes in glioblastoma for the first time, and clarified the impact of ferroptosis-related risk genes on M1/M2 macrophage polarization and patient prognosis.

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Emerging roles of ferroptosis in glioma

Cited by 11 publications

References 206 publications

Induction of ferroptosis by natural phenols: A promising strategy for cancer therapy

Induction of ferroptosis by natural phenols: A promising strategy for cancer therapy

Attributing Meaning to Molecular Interaction Networks by Leveraging Clinical and Omic Data: The Missing Link between Tumor Biology and Treatment Strategies in Glioma

Impact of ferroptosis-related risk genes on macrophage M1/M2 polarization and prognosis in glioblastoma

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