Emerging roles of lncRNA in Nasopharyngeal Carcinoma and therapeutic opportunities

Abstract

Nasopharyngeal carcinoma (NPC) is a kind of malignant tumor with ethnic and geographical distribution characteristics. However, the molecular mechanisms of NPC are still unclear. Long non encoding RNAs (lncRNAs) are becoming important regulators in gene expression networks, including post transcriptional and post translational regulation of protein, protein complex organization, signal transduction and recombination among cells, which are involved in cancer recognition. Recent evidence shows that lncRNAs play important roles in the occurrence and development of NPC. Therefore, in-depth understanding of abnormal lncRNAs will provide new understanding of the pathogenesis in NPC, and provide new tools for the early diagnosis and treatment of NPC. This article reviews the abnormal lncRNAs in NPC cells and the roles of lncRNAs in the tumorigenesis of NPC. In addition, we also discuss the diagnostic and therapeutic potential of lncRNAs in NPC.

The Long Noncoding RNA Cytoskeleton Regulator RNA (CYTOR)/miRNA-24-3p Axis Facilitates Nasopharyngeal Carcinoma Progression by Modulating GAD1 Expression

“…In CRC, CYTOR functions as a sponge to suppress the expression and function of miRNA [ 58 ], and CYTOR inhibition upregulates miR-215, which targets CKD13 to suppress the development of liver cancer [ 59 ]. Also, lncRNAs play important roles in the development of NPCs [ 17 ]. LncRNA CYTOR regulates mitochondrial metabolism and glycolysis of oral cancer cells via HNRNPC-mediated ZEB1 stabilization in oral squamous cell carcinoma [ 60 ], and the level of CYTOR could be upregulated by forkhead box D1 to promote EMT and chemoresistance in oral squamous cell carcinoma [ 61 ].…”

“…LncRNA and miRNA are small noncoding RNAs that play critical roles in regulating the development and metastasis of NPC [ 17 , 18 ]. miR-24-3p is downregulated in NPC and targets Jab1/CSN5 to modulate NPC cell function [ 19 ].…”

Long noncoding RNA LINC00930 promotes PFKFB3-mediated tumor glycolysis and cell proliferation in nasopharyngeal carcinoma

“…Antisense oligonucleotides (ASOs) are short, chemically synthesized single-stranded oligonucleotides with good stability, target binding properties, and low biological toxicity [39,40]. Here, we designed and synthesized three ASOs of LINC00930.…”

Noncoding RNA-mediated regulation of pyroptotic cell death in cancer

“…It remains unclear how MEG3 regulates the activation of NLRP3 inflammasome. Given that lncRNAs act as pivotal regulators of gene expression through diverse molecular mechanisms ( 138 ), the mode of action of MEG3 in cisplatin-induced pyroptosis is worthy of further investigation.…”