Emerging Roles of Prostaglandins in HIV-1 Transcription

Dumais, Nancy; Côté, Sandra; Ducharme, Anne-Marie

doi:10.5772/20858

Cited by 1 publication

(1 citation statement)

References 167 publications

(153 reference statements)

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“…PGE 2 is a strong chemotactic agent for neutrophils [ 82 ]. Over the years, studies have shown that overt expression of PGE 2 and its signaling is found in numerous disorders including cervical cancer [ 83 , 84 ] and women infected with HIV and HPV [ 85 , 86 ]. It has been shown that PGE 2 potentiates the chronic inflammatory response seen in these diseases, leading to greater tumorigenesis (cervical cancer) [ 84 ] and enhanced viral replication (HIV infection) [ 87 ].…”

Section: Sf a Potent Inflammatory Mediator In The Fmrtmentioning

confidence: 99%

Seminal Fluid-Mediated Inflammation in Physiology and Pathology of the Female Reproductive Tract

Adefuye

Adeola

Sales

et al. 2016

Journal of Immunology Research

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Inflammation is a multifaceted process involving a host of resident and recruited immune cells that eliminate the insult or injury and initiate tissue repair. In the female reproductive tract (FMRT), inflammation-mediated alterations in epithelial, vascular, and immune functions are important components of complex physiological processes and many local and systemic pathologies. It is well established that intracoital and postcoital function of seminal fluid (SF) goes beyond nutritive support for the spermatozoa cells. SF, in particular, the inflammatory bioactive lipids, and prostaglandins present in vast quantities in SF, have a role in localized immune modulation and regulation of pathways that can exacerbate inflammation in the FMRT. In sexually active women SF-mediated inflammation has been implicated in physiologic processes such as ovulation, implantation, and parturition while also enhancing tumorigenesis and susceptibility to infection. This review highlights the molecular mechanism by which SF regulates inflammatory pathways in the FMRT and how alterations in these pathways contribute to physiology and pathology of the female reproductive function. In addition, based on findings from TaqMan® 96-Well Plate Arrays, on neoplastic cervical cells treated with SF, we discuss new findings on the role of SF as a potent driver of inflammatory and tumorigenic pathways in the cervix.

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