Emerging roles of SnoRNAs in the pathogenesis and treatment of autoimmune disorders

Dubey, Gaurav; Singh, Mithilesh; Singh, Himmat; Agarwal, Mohit; Chandel, Shailendra Singh; Mishra, Anurag; Singh, Ravindra Pal; Kukreti, Neelima

doi:10.1016/j.prp.2023.154952

Cited by 4 publications

(1 citation statement)

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“…Lastly, Dubey et al published a comprehensive review on the roles of dysregulated snoRNAs in the pathogenesis and treatment of autoimmune disorders [ 235 ]. Altered expression levels of snoRNAs have been reported in various autoimmune diseases, including systemic lupus erythematosus, rheumatoid arthritis, and multiple sclerosis.…”

Section: Conclusion and The Road Ahead For Snornamentioning

confidence: 99%

Subverting the Canon: Novel Cancer-Promoting Functions and Mechanisms for snoRNAs

Huo,

Rai,

Nakatsu

et al. 2024

IJMS

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Small nucleolar RNAs (snoRNAs) constitute a class of intron-derived non-coding RNAs ranging from 60 to 300 nucleotides. Canonically localized in the nucleolus, snoRNAs play a pivotal role in RNA modifications and pre-ribosomal RNA processing. Based on the types of modifications they involve, such as methylation and pseudouridylation, they are classified into two main families—box C/D and H/ACA snoRNAs. Recent investigations have revealed the unconventional synthesis and biogenesis strategies of snoRNAs, indicating their more profound roles in pathogenesis than previously envisioned. This review consolidates recent discoveries surrounding snoRNAs and provides insights into their mechanistic roles in cancer. It explores the intricate interactions of snoRNAs within signaling pathways and speculates on potential therapeutic solutions emerging from snoRNA research. In addition, it presents recent findings on the long non-coding small nucleolar RNA host gene (lncSNHG), a subset of long non-coding RNAs (lncRNAs), which are the transcripts of parental SNHGs that generate snoRNA. The nucleolus, the functional epicenter of snoRNAs, is also discussed. Through a deconstruction of the pathways driving snoRNA-induced oncogenesis, this review aims to serve as a roadmap to guide future research in the nuanced field of snoRNA–cancer interactions and inspire potential snoRNA-related cancer therapies.

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Section: Conclusion and The Road Ahead For Snornamentioning

confidence: 99%